{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:38:48Z","timestamp":1792809528297,"version":"4.5.0"},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Biopsies of tumors located in deep midline structures require highly accurate stereotaxy to safely obtain lesional tissue suitable for molecular and histological analysis. Versatile platforms are needed to meet a broad range of technical requirements and surgeon preferences. The authors present their institutional experience with the robotic stereotactic assistance (ROSA) system in a series of robot-assisted biopsies of pediatric brainstem and thalamic tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A retrospective analysis was performed of 22 consecutive patients who underwent 23 stereotactic biopsies of brainstem or thalamic lesions using the ROSA platform at Rady Children\u2019s Hospital in San Diego between December 2015 and January 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The ROSA platform enabled rapid acquisition of lesional tissue across various combinations of approaches, registration techniques, and positioning. No permanent deficits, major adverse outcomes, or deaths were encountered. One patient experienced temporary cranial neuropathy, and 3 developed small asymptomatic hematomas. The diagnostic success rate of the ROSA system was 91.3%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Robot-assisted stereotactic biopsy of these lesions may be safely performed using the ROSA platform. This experience comprises the largest clinical series to date dedicated to robot-assisted biopsies of brainstem and diencephalic tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2020.7.peds20373","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T02:10:04Z","timestamp":1608862204000},"page":"317-324","source":"Crossref","is-referenced-by-count":40,"title":["Robot-assisted stereotactic biopsy of pediatric brainstem and thalamic lesions"],"prefix":"10.3171","volume":"27","author":[{"given":"Mihir","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of California, San Diego, La Jolla, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany M.","family":"Chan","sequence":"additional","affiliation":[{"name":"Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Santiago-Dieppa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California, San Diego, La Jolla, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anudeep","family":"Yekula","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Children\u2019s National Health System, Washington, DC; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer D.","family":"Elster","sequence":"additional","affiliation":[{"name":"Department of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Department of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California, San Diego, La Jolla, California;"},{"name":"Division of Neurosurgery, Rady Children\u2019s Hospital, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Gonda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California, San Diego, La Jolla, California;"},{"name":"Division of Neurosurgery, Rady Children\u2019s Hospital, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"3","key":"b1","series-title":"Acta Neuropathol","first-page":"603","article-title":"cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas","volume":"139","author":"Brat DJ","year":"2020","unstructured":"Brat DJ, Aldape K, Colman H,  cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas. 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Neurosurg Focus. 2020;48(1):E4.31896081"},{"issue":"5","key":"b4","series-title":"Neurosurg Focus","first-page":"E7","article-title":"Robot-assisted procedures in pediatric neurosurgery","volume":"42","author":"De Benedictis A","year":"2017","unstructured":"De Benedictis A, Trezza A, Carai A,  Robot-assisted procedures in pediatric neurosurgery. Neurosurg Focus. 2017;42(5):E7.28463617"},{"issue":"2","key":"b5","series-title":"Stereotact Funct Neurosurg","first-page":"79","article-title":"Stereotactic biopsy for brainstem tumors: comparison of transcerebellar with transfrontal approach","volume":"90","author":"Dellaretti M","year":"2012","unstructured":"Dellaretti M, Reyns N, Touzet G,  Stereotactic biopsy for brainstem tumors: comparison of transcerebellar with transfrontal approach. Stereotact Funct Neurosurg. 2012;90(2):79\u201383.22286495"},{"issue":"2","key":"b6","series-title":"J Neurosurg","first-page":"342","article-title":"Frameless robotic stereotactic biopsies: a consecutive series of 100 cases","volume":"122","author":"Lefranc M","year":"2015","unstructured":"Lefranc M, Capel C, Pruvot-Occean AS,  Frameless robotic stereotactic biopsies: a consecutive series of 100 cases. J Neurosurg. 2015;122(2):342\u2013352.25380111"},{"issue":"1","key":"b7","series-title":"J Neurosurg","first-page":"150","article-title":"A novel robot-guided minimally invasive technique for brain tumor biopsies","volume":"132","author":"Minchev G","year":"2020","unstructured":"Minchev G, Kronreif G, Ptacek W,  A novel robot-guided minimally invasive technique for brain tumor biopsies. J Neurosurg. 2020;132(1):150\u2013158."},{"issue":"7","key":"b8","series-title":"J Child Neurol","first-page":"907","article-title":"Benefit of stereotactic procedures in a series of 43 children","volume":"31","author":"Quick-Weller J","year":"2016","unstructured":"Quick-Weller J, Lescher S, Kashefiolasl S,  Benefit of stereotactic procedures in a series of 43 children. J Child Neurol. 2016;31(7):907\u2013912."},{"issue":"3","key":"b9","series-title":"Acta Neurochir (Wien)","first-page":"545","article-title":"Stereotactic brain biopsy: evaluation of robot-assisted procedure in 60 patients","volume":"161","author":"Terrier L","year":"2019","unstructured":"Terrier L, Gilard V, Marguet F,  Stereotactic brain biopsy: evaluation of robot-assisted procedure in 60 patients. Acta Neurochir (Wien). 2019;161(3):545\u2013552.30675655"},{"key":"b10","series-title":"World Neurosurg","first-page":"e450","article-title":"Experience with 102 frameless stereotactic biopsies using the neuromate robotic device","volume":"123","author":"Yasin H","year":"2019","unstructured":"Yasin H, Hoff HJ, Bl\u00fcmcke I, Simon M. Experience with 102 frameless stereotactic biopsies using the neuromate robotic device. World Neurosurg. 2019;123:e450\u2013e456.30500594"},{"key":"b11","series-title":"World Neurosurg","first-page":"584","article-title":"Robot-assisted stereotactic biopsy of diffuse intrinsic pontine glioma: a single-center experience","volume":"101","author":"Carai A","year":"2017","unstructured":"Carai A, Mastronuzzi A, De Benedictis A,  Robot-assisted stereotactic biopsy of diffuse intrinsic pontine glioma: a single-center experience. World Neurosurg. 2017;101:584\u2013588.28254596"},{"issue":"6","key":"b12","series-title":"A technical note. 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J Robot Surg. 2019;13(4):575\u2013579.30523502"},{"issue":"5","key":"b14","series-title":"Neurochirurgie","first-page":"363","article-title":"Stereotactic robot-guided biopsies of brain stem lesions: experience with 15 cases","volume":"56","author":"Haegelen C","year":"2010","unstructured":"Haegelen C, Touzet G, Reyns N,  Stereotactic robot-guided biopsies of brain stem lesions: experience with 15 cases. Neurochirurgie. 2010;56(5):363\u2013367.20728907"},{"issue":"2","key":"b15","series-title":"J Neurosurg Pediatr","first-page":"125","article-title":"Robot-assisted endoscopic third ventriculostomy: institutional experience in 9 patients","volume":"20","author":"Hoshide R","year":"2017","unstructured":"Hoshide R, Calayag M, Meltzer H,  Robot-assisted endoscopic third ventriculostomy: institutional experience in 9 patients. J Neurosurg Pediatr. 2017;20(2):125\u2013133.28598265"},{"issue":"2","key":"b16","series-title":"IEEE Trans Biomed Eng","first-page":"153","article-title":"A robot with improved absolute positioning accuracy for CT guided stereotactic brain surgery","volume":"35","author":"Kwoh YS","year":"1988","unstructured":"Kwoh YS, Hou J, Jonckheere EA, Hayati S. A robot with improved absolute positioning accuracy for CT guided stereotactic brain surgery. IEEE Trans Biomed Eng. 1988;35(2):153\u2013160.3280462"},{"issue":"1","key":"b17","series-title":"Neurosurgery","first-page":"27","article-title":"Computer- and robot-assisted resection of thalamic astrocytomas in children","volume":"29","author":"Drake JM","year":"1991","unstructured":"Drake JM, Joy M, Goldenberg A, Kreindler D. Computer- and robot-assisted resection of thalamic astrocytomas in children. Neurosurgery. 1991;29(1):27\u201333.1870684"},{"issue":"3","key":"b18","series-title":"J Neurosurg Pediatr","first-page":"261","article-title":"Update on the diagnostic value and safety of stereotactic biopsy for pediatric brainstem tumors: a systematic review and meta-analysis of 735 cases","volume":"20","author":"Hamisch C","year":"2017","unstructured":"Hamisch C, Kickingereder P, Fischer M,  Update on the diagnostic value and safety of stereotactic biopsy for pediatric brainstem tumors: a systematic review and meta-analysis of 735 cases. J Neurosurg Pediatr. 2017;20(3):261\u2013268.28621573"},{"issue":"6","key":"b19","series-title":"Neurosurgery","first-page":"873","article-title":"Diagnostic value and safety of stereotactic biopsy for brainstem tumors: a systematic review and meta-analysis of 1480 cases","volume":"72","author":"Kickingereder P","year":"2013","unstructured":"Kickingereder P, Willeit P, Simon T, Ruge MI. 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Int J Radiat Oncol Biol Phys. 1998;40(2):265\u2013271.9457808"},{"issue":"9","key":"b25","series-title":"Neuro Oncol","first-page":"1279","article-title":"Contemporary survival endpoints: an International Diffuse Intrinsic Pontine Glioma Registry study","volume":"19","author":"Cooney T","year":"2017","unstructured":"Cooney T, Lane A, Bartels U,  Contemporary survival endpoints: an International Diffuse Intrinsic Pontine Glioma Registry study. Neuro Oncol. 2017;19(9):1279\u20131280.28821206"},{"issue":"6","key":"b26","series-title":"Neurosurgery","first-page":"1026","article-title":"Magnetic resonance scans should replace biopsies for the diagnosis of diffuse brain stem gliomas: a report from the Children\u2019s Cancer Group","volume":"33","author":"Albright AL","year":"1993","unstructured":"Albright AL, Packer RJ, Zimmerman R,  Magnetic resonance scans should replace biopsies for the diagnosis of diffuse brain stem gliomas: a report from the Children\u2019s Cancer Group. Neurosurgery. 1993;33(6):1026\u20131030.8133987"},{"issue":"3","key":"b27","series-title":"Acta Neuropathol","first-page":"439","article-title":"K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas","volume":"124","author":"Khuong-Quang DA","year":"2012","unstructured":"Khuong-Quang DA, Buczkowicz P, Rakopoulos P,  K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. 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