{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:15:59Z","timestamp":1793042159535,"version":"4.5.0"},"reference-count":19,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The insula is a complex anatomical structure. Accessing tumors in the insula remains a challenge due to its anatomical complexity and the high chance of morbidity. The goal of this study was to evaluate the feasibility of an endoscopic transorbital approach (ETOA) to the insular region based on a cadaveric study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>One cadaveric head was used to study the anatomy of the insula and surrounding vessels. Then, anatomical dissection was performed in 4 human cadaveric heads using a dedicated endoscopic system with the aid of neuronavigation guidance. To assess the extent of resection, CT scanning was performed before and after dissection. The insular region was directly exposed by a classic transcranial approach to check the extent of resection from the side with a classic transcranial approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The entire procedure consisted of two phases: an extradural orbital phase and an intradural sylvian phase. After eyelid incision, the sphenoid bone and orbital roof were extensively drilled out with exposure of the frontal and temporal dural layers. After making a dural window, the anterior ramus of the sylvian fissure was opened and dissected. The M\n                      <jats:sub>2<\/jats:sub>\n                      segment of the middle cerebral artery (MCA) was identified and traced posterolaterally. A small corticectomy was performed on the posterior orbital gyrus. Through the window between the lateral lenticulostriate arteries and M\n                      <jats:sub>2<\/jats:sub>\n                      , the cortex and medulla of the insula were resected in an anteroposterior direction without violation of the M\n                      <jats:sub>2<\/jats:sub>\n                      segment of the MCA or its major branches. When confirmed by pterional craniotomy, the sylvian fissure and the MCA were found to be anatomically preserved. After validation of the feasibility and safety based on a cadaveric study, the ETOA was successfully performed in a patient with a high-grade glioma (WHO grade III) in the right insula.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The transorbital route can be considered a potential option to access tumors located in the insula. Using an ETOA, the MCA and its major branches were identified and preserved while removal was performed along the long axis of the insula. In particular, lesions in the anterior part of the insula are most benefited by this approach. Because this approach was implemented in only one patient, additional discussion and further verification is required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2020.8.jns202255","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T03:00:38Z","timestamp":1611284438000},"page":"1164-1172","source":"Crossref","is-referenced-by-count":28,"title":["Endoscopic transorbital approach to the insular region: cadaveric feasibility study and clinical application (SevEN-005)"],"prefix":"10.3171","volume":"135","author":[{"given":"Eui Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"},{"name":"Brain Tumor Center, Severance Hospital, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihwan","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Ho","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Woong","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Seong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ewha Seoul Hospital, Ewha Womans University College of Medicine, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Sook","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yonsei University College of Medicine, Seoul; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Hyung","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"},{"name":"Brain Tumor Center, Severance Hospital, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Gu","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"},{"name":"Brain Tumor Center, Severance Hospital, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hee","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"},{"name":"Brain Tumor Center, Severance Hospital, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hoon","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"4","key":"b1","series-title":"J Clin Neurophysiol","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1097\/WNP.0000000000000377","article-title":"Structure and function of the human insula","volume":"34","author":"Uddin LQ","year":"2017","unstructured":"Uddin LQ, Nomi JS, H\u00e9bert-Seropian B,  Structure and function of the human insula. 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