{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:38:09Z","timestamp":1792809489458,"version":"4.5.0"},"reference-count":31,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Chiari 1.5 malformation is a subgroup of the Chiari malformation in which tonsillar descent into the foramen magnum is accompanied by brainstem descent. No data exist on whether operative decompression in patients with Chiari 1.5 improves sleep-related breathing disorders (SRBDs) and whether there are radiological parameters predicting improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors performed a retrospective cohort study of consecutive pediatric patients with Chiari 1.5 malformation and SRBDs at the Alberta Children\u2019s Hospital. An SRBD was characterized using nocturnal polysomnography (PSG), specifically with the apnea-hypopnea index (AHI), the obstructive apnea index, and the central apnea index. Preoperative values for each of these indices were compared to those following surgical decompression. The authors also compared preoperative radiographic factors as predictors to both preoperative AHI and the change in AHI with surgery. Radiological factors included tonsillar and obex descent beneath the basion\u2013opisthion line, the presence of syringomyelia, the frontooccipital horn ratio, the pB\u2013C2 line, and the clivoaxial angle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Seven patients (5 males, 2 females) met inclusion criteria. One patient had two surgical decompressions, each with pre- and postoperative PSG studies (n = 8). The median age was 9 years. Before surgical decompression, 75% underwent tonsillectomy\/adenoidectomy. The majority (87.5%) experienced snoring\/witnessed apnea preoperatively. The median tonsillar and obex descent values were 21.3 mm and 11.2 mm, respectively. The median values for the pB\u2013C2 line and clivoaxial angle were 5.4 mm (interquartile range [IQR] 4.5 mm, 6.8 mm) and 144\u00b0 (IQR 139\u00b0, 167\u00b0), respectively. There was a statistically significant change from preoperative to postoperative AHI (19.7 vs 5.1, p = 0.015) and obstructive apnea index (4.5 vs 1.0, p = 0.01). There was no significant change in the central apnea index with surgery (0.9 vs 0.3, p = 0.12). No radiological factors were statistically significant in predicting preoperative AHI and change in AHI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This is the first series of pediatric patients with Chiari 1.5 with SRBDs who demonstrated a marked improvement in their PSG results postdecompression. Sleep apnea has a significant impact on learning and development in children, highlighting the urgency to recognize Chiari 1.5 as a more severe form of the Chiari I malformation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2020.8.peds20462","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T02:10:21Z","timestamp":1611886221000},"page":"452-458","source":"Crossref","is-referenced-by-count":3,"title":["The relationship between Chiari 1.5 malformation and sleep-related breathing disorders on polysomnography"],"prefix":"10.3171","volume":"27","author":[{"given":"Nicholas","family":"Sader","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, Alberta Children\u2019s Hospital, University of Calgary;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Hader","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Alberta Children\u2019s Hospital, University of Calgary;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Hockley","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Alberta Hospital, University of Alberta, Edmonton; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Kirk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Alberta Children\u2019s Hospital, University of Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adetayo","family":"Adeleye","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Medicine, Alberta Children\u2019s Hospital, University of Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Riva-Cambrin","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Alberta Children\u2019s Hospital, University of Calgary;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"5","key":"b1","series-title":"Chest","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1378\/chest.14-0970","article-title":"International classification of sleep disorders-third edition: highlights and modifications","volume":"146","author":"Sateia MJ","year":"2014","unstructured":"Sateia MJ\n. \nInternational classification of sleep disorders-third edition: highlights and modifications. 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