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Tumor fluorescence was detected through intact dura, and the visual contrast between disease and peritumoral healthy brain was enhanced after tumor exposure. Residual cancerous tissue was identified with strong fluorescence in resection cavity after en bloc tumor removal. Minimal fluorescence remained in the final wound bed, likely from nonenhancing tumor. Fluorescence was heterogeneously distributed at the infiltrative margin in resected tumor pieces imaged ex vivo. Postoperative MRI confirmed gross-total resection.<\/jats:p>\n                  <jats:p>\n                    The video can be found here:\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/stream.cadmore.media\/r10.3171\/2021.10.FOCVID21201\">https:\/\/stream.cadmore.media\/r10.3171\/2021.10.FOCVID21201<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.3171\/2021.10.focvid21201","type":"journal-article","created":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T10:23:00Z","timestamp":1641032580000},"page":"V9","source":"Crossref","is-referenced-by-count":4,"title":["Fluorescence-guided craniotomy of glioblastoma using panitumumab-IRDye800"],"prefix":"10.3171","volume":"6","author":[{"given":"Quan","family":"Zhou","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Otolaryngology\u2013Head & Neck Surgery, Stanford University School of Medicine, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"15","key":"r1","series-title":"Theranostics","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.7150\/thno.60582","article-title":"EGFR-targeted intraoperative fluorescence imaging detects high-grade glioma with panitumumab-IRDye800 in a phase 1 clinical trial","volume":"11","author":"Zhou Q","year":"2021","unstructured":"Zhou Q, van den Berg NS, Rosenthal EL,  EGFR-targeted intraoperative fluorescence imaging detects high-grade glioma with panitumumab-IRDye800 in a phase 1 clinical trial. 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