{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:33:13Z","timestamp":1793860393682,"version":"4.6.1"},"reference-count":34,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>The authors sought to determine the antiseizure effects of deep brain stimulation (DBS) of the parahippocampal cortex (PHC) for treatment of drug-resistant mesial temporal lobe epilepsy (MTLE).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>After a 3-month baseline period, 6 adult patients with drug-resistant MTLE and hippocampal sclerosis (HS) had stereoelectroencephalography (SEEG)\u2013DBS electrodes implanted at the PHC for identification of the seizure onset zone (SOZ). Patients entered an 8-month, randomized, double-blind protocol for DBS, followed by a 12-month open-phase study. Monthly reports of seizure frequency were collected, with separate counting of focal seizures with or without awareness impairment (focal impaired awareness seizures [FIAS] or focal aware seizures [FAS], respectively) and focal evolving to bilateral generalized tonic clonic seizures (GTCS). Stimulation parameters were 130 Hz, 450 \u03bcsec, 2.5\u20133 V, and cyclic stimulation 1 minute on\/4 minutes off.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The total seizure rate decrement during follow-up was 41% (CI 25%\u201356%), with better seizure control for GTCS (IQR 19%\u201320%) and FIAS (IQR 0%\u201316%), with FAS being less responsive (IQR 67%\u2013236%). No neuropsychological deterioration was observed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>PHC DBS induced important antiseizure effects in patients with incapacitating FIAS and GTCS, most likely through blocking the propagation of hippocampal-onset seizures. The PHC target can be easily and safely approached due to positioning away from vascular structures, and there was no evidence of DBS-induced cognitive deterioration.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2021.10.jns211380","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T08:09:03Z","timestamp":1645776543000},"page":"768-775","source":"Crossref","is-referenced-by-count":9,"title":["Optimizing deep brain stimulation for the treatment of drug-resistant temporal lobe epilepsy: a pilot study"],"prefix":"10.3171","volume":"137","author":[{"given":"Pablo E.","family":"Saucedo-Alvarado","sequence":"first","affiliation":[{"name":"Epilepsy Clinic and Unit for Stereotactic and Functional Neurosurgery, Mexico General Hospital \u201cDr. Eduardo Liceaga,\u201d Mexico City; and"},{"name":"Programa de Doctorado en Ciencias Biom\u00e9dicas, Divisi\u00f3n de Estudios de Posgrado, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luisa","family":"Velasco","sequence":"additional","affiliation":[{"name":"Epilepsy Clinic and Unit for Stereotactic and Functional Neurosurgery, Mexico General Hospital \u201cDr. Eduardo Liceaga,\u201d Mexico City; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Aguado-Carrillo","sequence":"additional","affiliation":[{"name":"Epilepsy Clinic and Unit for Stereotactic and Functional Neurosurgery, Mexico General Hospital \u201cDr. Eduardo Liceaga,\u201d Mexico City; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manola","family":"Cuellar-Herrera","sequence":"additional","affiliation":[{"name":"Epilepsy Clinic and Unit for Stereotactic and Functional Neurosurgery, Mexico General Hospital \u201cDr. Eduardo Liceaga,\u201d Mexico City; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Trejo-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Epilepsy Clinic and Unit for Stereotactic and Functional Neurosurgery, Mexico General Hospital \u201cDr. Eduardo Liceaga,\u201d Mexico City; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"M\u00e1rquez-Franco","sequence":"additional","affiliation":[{"name":"Epilepsy Clinic and Unit for Stereotactic and Functional Neurosurgery, Mexico General Hospital \u201cDr. Eduardo Liceaga,\u201d Mexico City; and"},{"name":"Programa de Doctorado en Ciencias Biom\u00e9dicas, Divisi\u00f3n de Estudios de Posgrado, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Velasco-Campos","sequence":"additional","affiliation":[{"name":"Epilepsy Clinic and Unit for Stereotactic and Functional Neurosurgery, Mexico General Hospital \u201cDr. Eduardo Liceaga,\u201d Mexico City; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"2","key":"b1","series-title":"Neuroepidemiology","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1159\/000503831","article-title":"The epidemiology of epilepsy","volume":"54","author":"Beghi E","year":"2020","unstructured":"Beghi E. 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