{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:25:50Z","timestamp":1794018350544,"version":"4.8.0"},"reference-count":37,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Patients with myelomeningocele often require multiple surgeries, but no study has clarified the kind of treatment given to these patients throughout their lives. The authors analyzed the type of surgery that was performed and at what age for Japanese patients with myelomeningoceles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The Japanese health claims data of 556 patients with myelomeningocele for the period from January 2005 to March 2020 provided by the Japan Medical Data Center Co., Ltd., were examined to investigate the number of surgeries performed and the patient age at surgery for each specialty. The patients were divided into two groups (those \u2264 18 years old [group A] and those &gt; 18 years old [group B]), and the way in which the types of surgery and the percentage of surgeries changed between these two groups was examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The mean follow-up period was 4.4 years. The mean age at the end of the overall follow-up was 18.6 years (range 0\u201370.5 years), and 1033 surgeries were performed on 294 patients (0.42 surgeries performed per patient per year) during this period. The number of surgeries for patients in group A was 818 in 192 patients, with 0.62 surgeries per patient per year, and for patients in group B it was 215 in 102 patients, with 0.19 surgeries per patient per year. The number of surgeries and the mean age at the time of surgery were as follows: 313 neurosurgeries, 5.16 years; 280 orthopedic surgeries, 11.36 years; 70 urological surgeries, 14.57 years; and 202 dermatological\/plastic surgeries, 16.19 years. In the surgeries related to myelomeningocele, the rates of CSF shunt placement, tethered cord release, muscle and tendon surgery, and other bone and joint surgery decreased significantly in group B, but they continued to undergo these surgeries. In group B, the rates of skin surgery, nephrostomy, ureterostomy, and cystostomy were significantly higher.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>A significant number of surgeries in multiple specialties related to myelomeningocele continue to be performed in adulthood, indicating that these patients require continuous care throughout their lives.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2021.12.peds21535","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T03:22:26Z","timestamp":1645154546000},"page":"479-487","source":"Crossref","is-referenced-by-count":4,"title":["Number of surgeries performed during the lifetime of patients with myelomeningocele"],"prefix":"10.3171","volume":"29","author":[{"given":"Masahiro","family":"Nonaka","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Kansai Medical University, Hirakata, Osaka;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruna","family":"Isozaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kansai Medical University, Hirakata, Osaka;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Komori","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kansai Medical University, Hirakata, Osaka;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamasa","family":"Kamei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kansai Medical University, Hirakata, Osaka;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kansai Medical University, Hirakata, Osaka;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Jikei Medical University, Minato-Ku, Tokyo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Yabe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hokkaido University, Sapporo, Hokkaido;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Zaitsu","sequence":"additional","affiliation":[{"name":"Department of Public Health, Dokkyo Medical University, Mibu, Tochigi; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nakashima","sequence":"additional","affiliation":[{"name":"National Hospital Organization, Matsue Medical Center, Matsue, Shimane, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kansai Medical University, Hirakata, Osaka;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Nat Rev Dis Primers","first-page":"15007","article-title":"Spina bifida","volume":"1","author":"Copp AJ","year":"2015","unstructured":"Copp AJ, Adzick NS, Chitty LS, Fletcher JM, Holmbeck GN, Shaw GM. Spina bifida. Nat Rev Dis Primers. 2015;1:15007.27189655"},{"issue":"4","key":"b2","series-title":"Neurosurg Focus","first-page":"E16","article-title":"Growing up with spina bifida: bridging the gaps in the transition of care from childhood to adulthood","volume":"47","author":"Patel SK","year":"2019","unstructured":"Patel SK, Staarmann B, Heilman A, Mains A, Woodward J, Bierbrauer KS. Growing up with spina bifida: bridging the gaps in the transition of care from childhood to adulthood. Neurosurg Focus. 2019;47(4):E16.31574470"},{"issue":"5)(suppl","key":"b3","series-title":"J Neurosurg","first-page":"368","article-title":"Myelomeningocele: long-term neurosurgical treatment and follow-up in 202 patients","volume":"107","author":"Talamonti G","year":"2007","unstructured":"Talamonti G, D\u2019Aliberti G, Collice M. Myelomeningocele: long-term neurosurgical treatment and follow-up in 202 patients. J Neurosurg. 2007;107(5)(suppl):368\u2013386.18459900"},{"issue":"6","key":"b4","series-title":"J Child Orthop","first-page":"441","article-title":"Orthopedic management of spina bifida. Part I: hip, knee, and rotational deformities","volume":"3","author":"Swaroop VT","year":"2009","unstructured":"Swaroop VT, Dias L. Orthopedic management of spina bifida. Part I: hip, knee, and rotational deformities. J Child Orthop. 2009;3(6):441\u2013449.19856195"},{"issue":"1","key":"b5","series-title":"Dev Disabil Res Rev","first-page":"96","article-title":"Orthopedic management of spina bifida","volume":"16","author":"Thomson JD","year":"2010","unstructured":"Thomson JD, Segal LS. Orthopedic management of spina bifida. Dev Disabil Res Rev. 2010;16(1):96\u2013103.20419777"},{"issue":"6","key":"b6","series-title":"J Child Orthop","first-page":"403","article-title":"Orthopaedic management of spina bifida-part II: foot and ankle deformities","volume":"5","author":"Swaroop VT","year":"2011","unstructured":"Swaroop VT, Dias L. Orthopaedic management of spina bifida-part II: foot and ankle deformities. J Child Orthop. 2011;5(6):403\u2013414.23205142"},{"issue":"2","key":"b7","series-title":"J Urol","first-page":"288","article-title":"Update on urological management of spina bifida from prenatal diagnosis to adulthood","volume":"194","author":"Snow-Lisy DC","year":"2015","unstructured":"Snow-Lisy DC, Yerkes EB, Cheng EY. Update on urological management of spina bifida from prenatal diagnosis to adulthood. J Urol. 2015;194(2):288\u2013296.25839383"},{"issue":"5","key":"b8","series-title":"J Epidemiol","first-page":"413","article-title":"Development of a database of health insurance claims: standardization of disease classifications and anonymous record linkage","volume":"20","author":"Kimura S","year":"2010","unstructured":"Kimura S, Sato T, Ikeda S, Noda M, Nakayama T. Development of a database of health insurance claims: standardization of disease classifications and anonymous record linkage. J Epidemiol. 2010;20(5):413\u2013419.20699602"},{"issue":"1","key":"b9","series-title":"BMC Pulm Med","first-page":"262","article-title":"Comorbidities associated with nontuberculous mycobacterial disease in Japanese adults: a claims-data analysis","volume":"20","author":"Uno S","year":"2020","unstructured":"Uno S, Asakura T, Morimoto K,  Comorbidities associated with nontuberculous mycobacterial disease in Japanese adults: a claims-data analysis. BMC Pulm Med. 2020;20(1):262.33036598"},{"issue":"1","key":"b10","series-title":"J Clin Biochem Nutr","first-page":"95","article-title":"Decline incidence in upper gastrointestinal bleeding in several recent years: data of the Japan claims database of 13 million accumulated patients","volume":"68","author":"Fujimoto S","year":"2021","unstructured":"Fujimoto S, Tsuruoka N, Esaki M,  Decline incidence in upper gastrointestinal bleeding in several recent years: data of the Japan claims database of 13 million accumulated patients. J Clin Biochem Nutr. 2021;68(1):95\u2013100.33536718"},{"issue":"5","key":"b11","series-title":"J Spinal Cord Med","first-page":"626","article-title":"Who needs surgery for pediatric myelomeningocele? A retrospective study and literature review","volume":"38","author":"Marreiros H","year":"2015","unstructured":"Marreiros H, Loff C, Calado E. Who needs surgery for pediatric myelomeningocele? A retrospective study and literature review. J Spinal Cord Med. 2015;38(5):626\u2013640.25029586"},{"issue":"2","key":"b12","series-title":"J Neurosurg Pediatr","first-page":"203","article-title":"Young adults with spina bifida transitioned to a medical home: a survey of medical care in Jacksonville, Florida","volume":"17","author":"Aguilera AM","year":"2016","unstructured":"Aguilera AM, Wood DL, Keeley C, James HE, Aldana PR. Young adults with spina bifida transitioned to a medical home: a survey of medical care in Jacksonville, Florida. J Neurosurg Pediatr. 2016;17(2):203\u2013207.26496631"},{"issue":"2","key":"b13","series-title":"J Neurosurg Pediatr","first-page":"227","article-title":"Correlation of mortality with lesion level in patients with myelomeningocele: a population-based study","volume":"19","author":"Borgstedt-Bakke JH","year":"2017","unstructured":"Borgstedt-Bakke JH, Fenger-Gr\u00f8n M, Rasmussen MM. Correlation of mortality with lesion level in patients with myelomeningocele: a population-based study. J Neurosurg Pediatr. 2017;19(2):227\u2013231.27911247"},{"issue":"12","key":"b14","series-title":"Am J Phys Med Rehabil","first-page":"861","article-title":"Co-morbidities associated with early mortality in adults with spina bifida","volume":"97","author":"Dicianno BE","year":"2018","unstructured":"Dicianno BE, Sherman A, Roehmer C, Zigler CK. Co-morbidities associated with early mortality in adults with spina bifida. Am J Phys Med Rehabil. 2018;97(12):861\u2013865.29757766"},{"issue":"3-4","key":"b15","series-title":"J Pediatr Rehabil Med","first-page":"275","article-title":"Evaluation of spina bifida transitional care practices in the United States","volume":"10","author":"Kelly MS","year":"2017","unstructured":"Kelly MS, Thibadeau J, Struwe S, Ramen L, Ouyang L, Routh J. Evaluation of spina bifida transitional care practices in the United States. J Pediatr Rehabil Med. 2017;10(3-4):275\u2013281.29125516"},{"issue":"9","key":"b16","series-title":"JAMA Netw Open","first-page":"e2127034","article-title":"Assessment of health literacy and self-reported readiness for transition to adult care among adolescents and young adults with spina bifida","volume":"4","author":"Rague JT","year":"2021","unstructured":"Rague JT, Kim S, Hirsch JA,  Assessment of health literacy and self-reported readiness for transition to adult care among adolescents and young adults with spina bifida. JAMA Netw Open. 2021;4(9):e2127034."},{"issue":"4","key":"b17","series-title":"J Pediatr Rehabil Med","first-page":"323","article-title":"The development of a lifetime care model in comprehensive spina bifida care","volume":"11","author":"Hopson B","year":"2018","unstructured":"Hopson B, Rocque BG, Joseph DB,  The development of a lifetime care model in comprehensive spina bifida care. 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Oper Neurosurg (Hagerstown). 2021;21(6):461\u2013466.34662909"},{"key":"b23","first-page":"e799","article-title":"Endoscopic third ventriculostomy in cases of ventriculoperitoneal shunt malfunction: does shunt duration play a role? World Neurosurg","volume":"127","author":"Talamonti G","year":"2019","unstructured":"Talamonti G, Nichelatti M, Picano M, Marcati E, D\u2019Aliberti G, Cenzato M. Endoscopic third ventriculostomy in cases of ventriculoperitoneal shunt malfunction: does shunt duration play a role? World Neurosurg. 2019;127:e799\u2013e808.30954740"},{"issue":"12","key":"b24","series-title":"Childs Nerv Syst","first-page":"3047","article-title":"Endoscopic third ventriculostomy in patients with myelomeningocele after shunt failure","volume":"36","author":"Furtado LMF","year":"2020","unstructured":"Furtado LMF, da Costa Val Filho JA, Holliday JB,  Endoscopic third ventriculostomy in patients with myelomeningocele after shunt failure. 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J Neurosurg Pediatr. 2021;28(1):21\u201321."},{"issue":"1","key":"b32","series-title":"J Neurosurg Pediatr","first-page":"99","article-title":"Scoliosis in myelomeningocele: epidemiology, management, and functional outcome","volume":"20","author":"Mummareddy N","year":"2017","unstructured":"Mummareddy N, Dewan MC, Mercier MR, Naftel RP, Wellons JCIII, Bonfield CM. Scoliosis in myelomeningocele: epidemiology, management, and functional outcome. J Neurosurg Pediatr. 2017;20(1):99\u2013108.28452655"},{"issue":"1","key":"b33","series-title":"J Pediatr Urol","first-page":"40.e1","article-title":"How successful is the transition to adult urology care in spina bifida? A single center 7-year experience","volume":"13","author":"Szymanski KM","year":"2017","unstructured":"Szymanski KM, Cain MP, Hardacker TJ, Misseri R. How successful is the transition to adult urology care in spina bifida? A single center 7-year experience. 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