{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:42:42Z","timestamp":1773150162366,"version":"3.50.1"},"reference-count":45,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Despite understanding the associated adverse outcomes, identifying hospitalized patients at risk for sepsis is challenging. The authors aimed to characterize the epidemiology and clinical risk of sepsis in patients who underwent vertebral fracture repair for traumatic spinal injury (TSI).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>The authors conducted a retrospective cohort analysis of adults undergoing vertebral fracture repair during initial hospitalization after TSI who were registered in the National Trauma Data Bank from 2011 to 2014.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Of the 29,050 eligible patients undergoing vertebral fracture repair, 317 developed sepsis during initial hospitalization. Of these patients, most presented after a motor vehicle accident (63%) or fall (28%). Patients in whom sepsis developed had greater odds of being male (adjusted OR [aOR] 1.5, 95% CI 1.1\u20131.9), having diabetes mellitus (aOR 1.5, 95% CI 1.11\u20132.1), and being obese (aOR 1.9, 95% CI 1.4\u20132.5). Additionally, they had greater odds of presenting with moderate (aOR 2.7, 95% CI 1.8\u20134.2) or severe (aOR 3.9, 95% CI 2.9\u20135.2) Glasgow Coma Scale scores and of having concomitant abdominal injuries (aOR 1.9, 95% CI 1.5\u20132.5) but not cranial, thoracic, or lower-extremity injuries. Interestingly, cervical spine injury was significantly associated with developing sepsis (OR 1.4, 95% CI 1.1\u20131.8), but thoracic and lumbar spine injuries were not. Spinal cord injury (OR 1.9, 95% CI 1.5\u20132.5) was also associated with sepsis regardless of level. Patients with sepsis were hospitalized approximately 16 days longer. They had greater odds of being discharged to rehabilitative care or home with rehabilitative care (OR 2.4, 95% CI 1.8\u20133.2) and greater odds of death or discharge to hospice (OR 6.0, 95% CI 4.4\u20138.1).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Among patients undergoing vertebral fracture repair, those with cervical spine fractures, spinal cord injuries, preexisting comorbidities, and severe concomitant injuries are at highest risk for developing postoperative sepsis and experiencing adverse hospital disposition.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2021.12.spine21423","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T07:20:36Z","timestamp":1645773636000},"page":"292-298","source":"Crossref","is-referenced-by-count":4,"title":["Spinal level and cord involvement in the prediction of sepsis development after vertebral fracture repair for traumatic spinal injury"],"prefix":"10.3171","volume":"37","author":[{"given":"Samantha E.","family":"Hoffman","sequence":"first","affiliation":[{"name":"Computational Neurosciences Outcomes Center, Department of Neurosurgery, Harvard Medical School, Brigham and Women\u2019s Hospital, Boston; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blake M.","family":"Hauser","sequence":"additional","affiliation":[{"name":"Computational Neurosciences Outcomes Center, Department of Neurosurgery, Harvard Medical School, Brigham and Women\u2019s Hospital, Boston; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark M.","family":"Zaki","sequence":"additional","affiliation":[{"name":"Computational Neurosciences Outcomes Center, Department of Neurosurgery, Harvard Medical School, Brigham and Women\u2019s Hospital, Boston; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saksham","family":"Gupta","sequence":"additional","affiliation":[{"name":"Computational Neurosciences Outcomes Center, Department of Neurosurgery, Harvard Medical School, Brigham and Women\u2019s Hospital, Boston; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Chua","sequence":"additional","affiliation":[{"name":"Computational Neurosciences Outcomes Center, Department of Neurosurgery, Harvard Medical School, Brigham and Women\u2019s Hospital, Boston; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua D.","family":"Bernstock","sequence":"additional","affiliation":[{"name":"Computational Neurosciences Outcomes Center, Department of Neurosurgery, Harvard Medical School, Brigham and Women\u2019s Hospital, Boston; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaz M.","family":"Khawaja","sequence":"additional","affiliation":[{"name":"Computational Neurosciences Outcomes Center, Department of Neurosurgery, Harvard Medical School, Brigham and Women\u2019s Hospital, Boston; and"},{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Computational Neurosciences Outcomes Center, Department of Neurosurgery, Harvard Medical School, Brigham and Women\u2019s Hospital, Boston; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan A.","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Computational Neurosciences Outcomes Center, Department of Neurosurgery, Harvard Medical School, Brigham and Women\u2019s Hospital, Boston; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"8","key":"b1","series-title":"Clin Infect Dis","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1093\/cid\/ciy342","article-title":"Combatting Sepsis: a public health perspective","volume":"67","author":"Dantes RB","year":"2018","unstructured":"Dantes RB, Epstein L. 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