{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:27:13Z","timestamp":1788017233259,"version":"build-2784847793"},"reference-count":72,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Moyamoya disease (MMD) is a rare cerebrovascular disease characterized by progressive occlusion of the internal carotid artery and the secondary formation of collateral vessels. Patients with MMD have ischemic attacks or intracranial bleeding, but the disease pathophysiology remains unknown. In this study, the authors aimed to identify a gene expression profile specific to the intracranial artery in MMD.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n This was a single-center, prospectively sampled, retrospective cohort study. Microsamples of the middle cerebral artery (MCA) were collected from patients with MMD (n = 11) and from control patients (n = 9). Using microarray techniques, transcriptome-wide analysis was performed.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Comparison of MCA gene expression between patients with MMD and control patients detected 62 and 26 genes whose expression was significantly (p < 0.001 and fold change > 2) up- or downregulated, respectively, in the MCA of MMD. Gene set enrichment analysis of genes expressed in the MCA of patients with MMD revealed positive correlations with genes involved in antigen processing and presentation, the dendritic cell pathway, cytokine pathway, and interleukin-12 pathway, and negative correlations with genes involved in oxidative phosphorylation and DNA repair. Microarray analysis was validated by quantitative polymerase chain reaction.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Transcriptome-wide analysis showed upregulation of genes for immune responses and downregulation of genes for DNA repair and oxidative phosphorylation within the intracranial artery of patients with MMD. These findings may represent clues to the pathophysiology of MMD.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2021.6.focus20870","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T07:39:35Z","timestamp":1630481975000},"page":"E3","source":"Crossref","is-referenced-by-count":33,"title":["Transcriptome-wide analysis of intracranial artery in patients with moyamoya disease showing upregulation of immune response, and downregulation of oxidative phosphorylation and DNA repair"],"prefix":"10.3171","volume":"51","author":[{"given":"Fumiaki","family":"Kanamori","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinya","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinobu","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Division of Research Creation and Biobank, Research Creation Support Center, Aichi Medical University, Nagakute;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivasundaram","family":"Karnan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikio","family":"Maruwaka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Toyota Kosei Hospital, Toyota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenzo","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kasugai Municipal Hospital, Kasugai;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Handa City Hospital, Handa; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Uda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Aichi Rehabilitation Hospital, Nishio, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Maesawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Natsume","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"11","key":"b1","series-title":"Lancet Neurol","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/S1474-4422(08)70240-0","article-title":"Moyamoya disease: current concepts and future perspectives","volume":"7","author":"Kuroda S","year":"2008","unstructured":"Kuroda S, Houkin K. 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