{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:12:18Z","timestamp":1790305938731,"version":"4.1.0"},"reference-count":148,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9]]},"abstract":"\n OBJECTIVE<\/jats:title>\n \n Moyamoya disease (MMD) is an intracranial steno-occlusive pathology characterized by progressive narrowing of proximal large vessels, including the terminal internal carotid arteries (ICAs), middle cerebral arteries, or anterior cerebral arteries. Named for the \u201cpuff of smoke\u201d appearance of the anomalous vascularization visualized on cerebral angiography, MMD lacks a well-defined etiology, although significant insights have been made, including the identification of a susceptibility gene,\n RNF213<\/jats:italic>\n , in humans with the disease. A limitation to advancing the understanding and treatment of MMD has been the lack of experimental animal models that authentically reflect the clinical pathogenesis. In an effort to analyze characteristics of currently available models and identify strategies for future model generation, the authors performed a scoping review of experimental animal models that have been used to study MMD.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n A systematic search of PubMed, Web of Science, and Scopus was performed to identify articles describing animal models used to study MMD. Additional articles were identified via citation searching. Study selection and data extraction were performed by two independent reviewers based on defined inclusion and exclusion criteria.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n A total of 44 articles were included for full-text review. The methods used to generate these animal models were broadly classified as surgical (n = 25, 56.8%), immunological (n = 7, 15.9%), genetic (n = 6, 13.6%), or a combination (n = 6, 13.6%). Surgical models typically involved permanent ligation of one or both of the common carotid arteries or ICAs to produce chronic cerebral hypoperfusion. Genetic models utilized known MMD or cerebrovascular disease-related genes, such as\n RNF213<\/jats:italic>\n or\n ACTA2<\/jats:italic>\n , to induce heritable cerebral vasculopathy. Finally, immunological models attempted to induce vasculitis-type pathology by recapitulating the inflammatory milieu thought to underlie MMD.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Models generated for MMD have involved three general approaches: surgical, immunological, and genetic. Although each reflects a key aspect of MMD pathogenesis, the failure of any individual model to recapitulate the development, progression, and consequences of the disease underscores the importance of future work in developing a multietiology model.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2021.6.focus21284","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T07:39:29Z","timestamp":1630481969000},"page":"E5","source":"Crossref","is-referenced-by-count":12,"title":["Experimental animal models for moyamoya disease and treatment: a pathogenesis-oriented scoping review"],"prefix":"10.3171","volume":"51","author":[{"given":"Michael S.","family":"Rallo","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Akel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhilesh","family":"Gurram","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Appl Clin Genet","first-page":"49","article-title":"Moyamoya disease and syndromes: from genetics to clinical management","volume":"8","author":"Guey S","year":"2015","unstructured":"Guey S, Tournier-Lasserve E, Herv\u00e9 D, Kossorotoff M. 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