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Findings from these omics data have the potential to reclassify CH according to a molecular nomenclature that may increase precision for genetic counseling, outcome prognostication, and treatment stratification. Beyond the immediate patient benefits, genomic data may also inform future clinical trials and catalyze the development of nonsurgical, molecularly targeted therapies. Therefore, the authors advocate for further application of genomic sequencing in clinical practice by the neurosurgical community as a diagnostic adjunct in the evaluation and management of patients diagnosed with CH.<\/jats:p>","DOI":"10.3171\/2021.8.peds21368","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T10:30:51Z","timestamp":1647340251000},"page":"168-177","source":"Crossref","is-referenced-by-count":11,"title":["Genomic approaches to improve the clinical diagnosis and management of patients with congenital hydrocephalus"],"prefix":"10.3171","volume":"29","author":[{"given":"Garrett","family":"Allington","sequence":"first","affiliation":[{"name":"Department of Pathology, Yale University School of Medicine, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan Q.","family":"Duy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ryou","sequence":"additional","affiliation":[{"name":"Department of Genetics, Washington University School of Medicine, St. Louis, Missouri;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Kiziltug","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Robert","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Kundishora","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"King","sequence":"additional","affiliation":[{"name":"Department of Genetics, Washington University School of Medicine, St. Louis, Missouri;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shozeb","family":"Haider","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University College London, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher T.","family":"Kahle","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut;"},{"name":"Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut;"},{"name":"Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut;"},{"name":"Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts;"},{"name":"Division of Genetics and Genomics, Boston Children\u2019s Hospital, Boston, Massachusetts; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng Chih","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Genetics, Washington University School of Medicine, St. Louis, Missouri;"},{"name":"Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Cerebrospinal Fluid Res","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1743-8454-5-2","article-title":"The definition and classification of hydrocephalus: a personal recommendation to stimulate debate","volume":"5","author":"Rekate HL","year":"2008","unstructured":"Rekate HL. 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