{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:17:48Z","timestamp":1788459468583,"version":"build-2803163510"},"reference-count":42,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Adult brainstem gliomas (BSGs) are rare tumors of the CNS that are poorly understood. Upregulation of the oncometabolite 2-hydroxyglutarate (2HG) in the tumor indicates the mutation of isocitrate dehydrogenase (IDH), which can be detected by magnetic resonance spectroscopy (MRS). Although histological examination is required for the definitive diagnosis of BSG, 2HG-optimized MRS (2HG-MRS) may be useful, considering the difficult nature of brainstem lesion biopsy. The aim of this study was to evaluate the utility of 2HG-MRS for diagnosing IDH-mutant adult BSG.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Patients with a radiographically confirmed brainstem tumor underwent 3T MRS. A single voxel was set in the lesion with reference to the T2 or fluid-attenuated inversion recovery image and analyzed according to the 2HG-tailored MRS protocol (point-resolved spectroscopic sequence; echo time 35 msec). All patients underwent intraoperative navigation-guided or CT-guided stereotactic biopsy for histopathological diagnosis. The status of IDH and H3K27M mutations was confirmed by immunohistochemistry and direct DNA sequencing. In addition, the authors examined the relationship between patients\u2019 2HG concentrations and survival time.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Ten patients (7 men, 3 women; median age 33.5 years) underwent 2HG-MRS and biopsy. Four patients had an H3K27M mutation and 4 had an <jats:italic>IDH1<\/jats:italic> mutation (1 R132H canonical IDH mutation, 2 R132S and 1 R132G noncanonical IDH mutations). Two had neither H3K27M nor IDH mutations. The H3K27M and IDH mutations were mutually exclusive. Most tumors were located in the pons. There was no significant radiological difference between mutant H3K27M and IDH on a conventional MRI sequence. A 2HG concentration \u2265 1.8 mM on MRS demonstrated 100% (95% CI 28%\u2013100%) sensitivity and 100% (95% CI 42%\u2013100%) specificity for IDH-mutant BSG (p = 0.0048). The median overall survival was 10 months in IDH\u2013wild-type BSG patients (n = 6) and could not be estimated in IDH-mutant BSG patients (n = 4) due to the small number of deaths (p = 0.008).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>2HG-MRS demonstrated high sensitivity and specificity for the prediction of IDH-mutant BSG. In addition, 2HG-MRS may be useful for predicting the prognosis of adult BSG patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2022.12.jns221954","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T15:39:31Z","timestamp":1674833971000},"page":"355-362","source":"Crossref","is-referenced-by-count":23,"title":["2-Hydroxyglutarate magnetic resonance spectroscopy in adult brainstem glioma"],"prefix":"10.3171","volume":"139","author":[{"given":"Hirofumi","family":"Iwahashi","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takiko","family":"Uno","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Hashiguchi","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Maeyama","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Somiya","sequence":"additional","affiliation":[{"name":"Division of Radiology, Kobe University Hospital, Kobe, Hyogo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Diagnostic Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Hyogo Cancer Center, Akashi, Hyogo; and"},{"name":"Pathology for Regional Communication, Kobe University Graduate School of Medicine, Kobe, Hyogo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Itoh","sequence":"additional","affiliation":[{"name":"Diagnostic Pathology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sasayama","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"3","key":"b1","series-title":"Oncologist","first-page":"388","article-title":"Adult brainstem gliomas","volume":"17","author":"Reyes-Botero G","year":"2012","unstructured":"Reyes-Botero G, Mokhtari K, Martin-Duverneuil N, Delattre JY, Laigle-Donadey F. 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