{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:11:22Z","timestamp":1792023082290,"version":"4.4.0"},"reference-count":49,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Numerous studies have confirmed a strong association between progestins and meningiomas and the regression and\/or stabilization of meningiomas after discontinuation of treatment. Osteomeningiomas represent a small subgroup of meningiomas that appear to be more common among progestin-related meningiomas. However, the specificity of the behavior of this subset of meningiomas after discontinuation of progestin has not yet been assessed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Thirty-six patients (mean age 49.5 years) who presented with at least one progestin-related osteomeningioma (48 tumors total) were identified from a prospectively collected database of patients and had been referred to our department for meningioma and had documented use of cyproterone acetate, nomegestrol acetate, and\/or chlormadinone acetate. Hormonal treatment was stopped at the time of diagnosis for all the patients, and the clinical and radiological evolution of this subgroup of tumors was evaluated.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>For half of the 36 patients, treatment was prescribed for signs of hyperandrogenism, such as hirsutism, alopecia, or acne. Most lesions were spheno-orbital (35.4%) or frontal (31.2%). Although the tissular part of the meningioma shrank in 77.1% of cases, the osseous part exhibited discordant behavior with 81.3% showing volume progression. The combination of estrogens, as well as the prolonged duration of progestin treatment, seems to increase the risk of progression of the osseous part after treatment discontinuation (p = 0.02 and p = 0.028, respectively). No patient required surgical treatment at diagnosis or during the study.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>These results show that while the soft intracranial part of progestin-related osteomeningioma tumor is the most likely to regress after treatment discontinuation, the bony part is more likely to increase in volume. These findings suggest the need for careful follow-up of these patients, especially those with tumors near the optical apparatus.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2022.12.jns222006","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T16:18:28Z","timestamp":1678465108000},"page":"944-952","source":"Crossref","is-referenced-by-count":12,"title":["Opposed evolution of the osseous and soft parts of progestin-associated osteomeningioma after progestin intake discontinuation"],"prefix":"10.3171","volume":"139","author":[{"given":"Simona M.","family":"Florea","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Passeri","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Abbritti","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne L.","family":"Bernat","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Fontanel","sequence":"additional","affiliation":[{"name":"Grand East Regional Health Authority, Nancy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Yoldjian","sequence":"additional","affiliation":[{"name":"French National Agency for the Safety of Medicines and Health Products (ANSM), Saint-Denis; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Funck-Brentano","sequence":"additional","affiliation":[{"name":"Rheumatology, Lariboisi\u00e8re Hospital, AP-HP, University of Paris;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Weill","sequence":"additional","affiliation":[{"name":"EPI-PHARE Scientific Interest Group, Saint-Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Mandonnet","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Froelich","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"12 suppl 2","key":"b1","series-title":"Neuro Oncol","first-page":"iii1","article-title":"CBTRUS Statistical Report: primary brain and other central nervous system tumors diagnosed in the United States in 2014-2018","volume":"23","author":"Ostrom QT","year":"2021","unstructured":"Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS. 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World Neurosurg. 2018;118:e918\u2013e924."},{"issue":"2","key":"b4","series-title":"Folia Neuropathol","first-page":"111","article-title":"Immunohistochemical expression of progesterone and estrogen receptors in meningiomas","volume":"44","author":"Omulecka A","year":"2006","unstructured":"Omulecka A, Papierz W, Nawrocka-Kunecka A, Lewy-Trenda I. Immunohistochemical expression of progesterone and estrogen receptors in meningiomas. Folia Neuropathol. 2006;44(2):111\u2013115."},{"issue":"6","key":"b5","series-title":"Cancer","first-page":"1626","article-title":"The association between breast carcinoma and meningioma in women","volume":"94","author":"Custer BS","year":"2002","unstructured":"Custer BS, Koepsell TD, Mueller BA. The association between breast carcinoma and meningioma in women. Cancer. 2002;94(6):1626\u20131635."},{"issue":"1","key":"b6","series-title":"Br J Neurosurg","first-page":"47","article-title":"The presence of progesterone receptors in arachnoid granulations and in the lining of arachnoid cysts: its relevance to expression of progesterone receptors in meningiomas","volume":"9","author":"Verhagen A","year":"1995","unstructured":"Verhagen A, Go KG, Visser GM, Blankenstein MA, Vaalburg W. The presence of progesterone receptors in arachnoid granulations and in the lining of arachnoid cysts: its relevance to expression of progesterone receptors in meningiomas. Br J Neurosurg. 1995;9(1):47\u201350."},{"issue":"1","key":"b7","series-title":"J Neurosurg","first-page":"113","article-title":"Progesterone and estrogen receptors in meningiomas: prognostic considerations","volume":"86","author":"Hsu DW","year":"1997","unstructured":"Hsu DW, Efird JT, Hedley-Whyte ET. Progesterone and estrogen receptors in meningiomas: prognostic considerations. J Neurosurg. 1997;86(1):113\u2013120."},{"issue":"suppl 1","key":"b8","series-title":"Hum Reprod","first-page":"202","article-title":"Role of antiprogestational therapy for meningiomas","volume":"9","author":"Grunberg SM","year":"1994","unstructured":"Grunberg SM. Role of antiprogestational therapy for meningiomas. Hum Reprod. 1994;9(suppl 1):202-207."},{"issue":"6","key":"b9","series-title":"J Neurosurg","first-page":"861","article-title":"Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone","volume":"74","author":"Grunberg SM","year":"1991","unstructured":"Grunberg SM, Weiss MH, Spitz IM,  Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone. J Neurosurg. 1991;74(6):861\u2013866."},{"issue":"4","key":"b10","series-title":"Neurosurg Focus","first-page":"E13","article-title":"Primary intraosseous meningioma","volume":"23","author":"Elder JB","year":"2007","unstructured":"Elder JB, Atkinson R, Zee CS, Chen TC. Primary intraosseous meningioma. Neurosurg Focus. 2007;23(4):E13."},{"issue":"2","key":"b11","series-title":"J Neurosurg","first-page":"281","article-title":"Primary intraosseous meningioma: clinical, histological, and differential diagnostic aspects","volume":"133","author":"Butscheidt S","year":"2020","unstructured":"Butscheidt S, Ernst M, Rolvien T,  Primary intraosseous meningioma: clinical, histological, and differential diagnostic aspects. J Neurosurg. 2020;133(2):281\u2013290."},{"issue":"1-2","key":"b12","series-title":"Maturitas","first-page":"171","article-title":"Classification and pharmacology of progestins","volume":"61","author":"Schindler AE","year":"2008","unstructured":"Schindler AE, Campagnoli C, Druckmann R,  Classification and pharmacology of progestins. 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Acta Neurochir (Wien). 2015;157(10):1741\u20131746."},{"issue":"3","key":"b15","series-title":"J Ophthalmic Vis Res","first-page":"355","article-title":"Regression of giant olfactory groove meningioma and complete visual acuity recovery after discontinuation of cyproterone acetate","volume":"13","author":"Bernat AL","year":"2018","unstructured":"Bernat AL, Bonnin S, Labidi M,  Regression of giant olfactory groove meningioma and complete visual acuity recovery after discontinuation of cyproterone acetate. J Ophthalmic Vis Res. 2018;13(3):355\u2013358."},{"issue":"6","key":"b16","series-title":"World Neurosurg","first-page":"e759","article-title":"Endoscopic, endonasal variability in the anatomy of the internal carotid artery","volume":"82","author":"Cebula H","year":"2014","unstructured":"Cebula H, Kurbanov A, Zimmer LA,  Endoscopic, endonasal variability in the anatomy of the internal carotid artery. 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J Neurooncol. 2021;152(2):279\u2013288."},{"issue":"2","key":"b25","series-title":"J Neurooncol","first-page":"331","article-title":"Cyproterone acetate and meningioma: a nationwide-wide population based study","volume":"151","author":"Champeaux-Depond C","year":"2021","unstructured":"Champeaux-Depond C, Weller J, Froelich S, Sartor A. Cyproterone acetate and meningioma: a nationwide-wide population based study. J Neurooncol. 2021;151(2):331\u2013338."},{"issue":"23","key":"b26","series-title":"N Engl J Med","first-page":"2411","article-title":"Growth of a meningioma in a transsexual patient after estrogen-progestin therapy","volume":"357","author":"Gazzeri R","year":"2007","unstructured":"Gazzeri R, Galarza M, Gazzeri G. Growth of a meningioma in a transsexual patient after estrogen-progestin therapy. N Engl J Med. 2007;357(23):2411\u20132412."},{"issue":"4","key":"b27","series-title":"Neurosurgery","first-page":"723","article-title":"Sphenoid wing meningioma progression after placement of a subcutaneous progesterone agonist contraceptive implant","volume":"34","author":"Piper JG","year":"1994","unstructured":"Piper JG, Follett KA, Fantin A. Sphenoid wing meningioma progression after placement of a subcutaneous progesterone agonist contraceptive implant. Neurosurgery. 1994;34(4):723\u2013725."},{"issue":"5","key":"b28","series-title":"Eur Respir J","first-page":"888","article-title":"Should patients with lymphangioleiomyomatosis undergo screening for meningioma?","volume":"24","author":"Cottin V","year":"2004","unstructured":"Cottin V, Vukusic S, Jouanneau E, Lazor R, Cordier JF. Should patients with lymphangioleiomyomatosis undergo screening for meningioma?. Eur Respir J. 2004;24(5):888\u2013889."},{"issue":"2","key":"b29","series-title":"Neurosurgery","first-page":"308","article-title":"Intracranial meningiomas decrease in volume on magnetic resonance imaging after discontinuing progestin","volume":"89","author":"Voormolen EHJ","year":"2021","unstructured":"Voormolen EHJ, Champagne PO, Roca E,  Intracranial meningiomas decrease in volume on magnetic resonance imaging after discontinuing progestin. Neurosurgery. 2021;89(2):308\u2013314."},{"issue":"3","key":"b30","series-title":"Ann Oncol","first-page":"681","article-title":"Progestin-associated shift of meningioma mutational landscape","volume":"29","author":"Peyre M","year":"2018","unstructured":"Peyre M, Gaillard S, de Marcellus C,  Progestin-associated shift of meningioma mutational landscape. Ann Oncol. 2018;29(3):681\u2013686."},{"issue":"10","key":"b31","series-title":"Nat Genet","first-page":"1253","article-title":"Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas","volume":"48","author":"Clark VE","year":"2016","unstructured":"Clark VE, Harmanc\u0131 AS, Bai H,  Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas. Nat Genet. 2016;48(10):1253\u20131259."},{"issue":"4","key":"b32","series-title":"Neurosurgery","first-page":"742","article-title":"Hyperostosis associated with meningioma of the cranial base: secondary changes or tumor invasion","volume":"44","author":"Pieper DR","year":"1999","unstructured":"Pieper DR, Al-Mefty O, Hanada Y, Buechner D. Hyperostosis associated with meningioma of the cranial base: secondary changes or tumor invasion. Neurosurgery. 1999;44(4):742\u2013747."},{"issue":"1","key":"b33","series-title":"J Neurooncol","first-page":"95","article-title":"Female gender and exogenous progesterone exposition as risk factors for spheno-orbital meningiomas","volume":"149","author":"Apra C","year":"2020","unstructured":"Apra C, Roblot P, Alkhayri A, Le Gu\u00e9rinel C, Polivka M, Chauvet D. Female gender and exogenous progesterone exposition as risk factors for spheno-orbital meningiomas. J Neurooncol. 2020;149(1):95\u2013101."},{"issue":"6","key":"b34","series-title":"Acta Neurochir (Wien)","first-page":"1705","article-title":"Sustained growth of intraosseous hormone-associated meningiomas after cessation of progestin therapy","volume":"163","author":"AbiJaoude S","year":"2021","unstructured":"AbiJaoude S, Marijon P, Roblot P,  Sustained growth of intraosseous hormone-associated meningiomas after cessation of progestin therapy. Acta Neurochir (Wien). 2021;163(6):1705\u20131710."},{"issue":"4","key":"b35","series-title":"Dev Dyn","first-page":"472","article-title":"Cranial sutures as intramembranous bone growth sites","volume":"219","author":"Opperman LA","year":"2000","unstructured":"Opperman LA. Cranial sutures as intramembranous bone growth sites. Dev Dyn. 2000;219(4):472\u2013485."},{"issue":"5","key":"b36","series-title":"Ann Anat","first-page":"453","article-title":"Etiopathogenesis of hyperostosis frontalis interna: a mystery still","volume":"193","author":"Raikos A","year":"2011","unstructured":"Raikos A, Paraskevas GK, Yusuf F,  Etiopathogenesis of hyperostosis frontalis interna: a mystery still. Ann Anat. 2011;193(5):453\u2013458."},{"key":"b37","series-title":"Proceedings of the 1946 Laurentian Hormone Conference","first-page":"293","article-title":"The effect of hormones on osteogenesis in man","author":"Albright F","year":"1946","unstructured":"Albright F. The effect of hormones on osteogenesis in man. In: Proceedings of the 1946 Laurentian Hormone Conference. Elsevier;1946:293-353."},{"issue":"1","key":"b38","series-title":"J Clin Invest","first-page":"24","article-title":"The metabolic effects of steroid hormones in osteoporosis","volume":"26","author":"Reifenstein EC Jr","year":"1947","unstructured":"Reifenstein EC Jr, Albright F. The metabolic effects of steroid hormones in osteoporosis. J Clin Invest. 1947;26(1):24\u201356."},{"issue":"2","key":"b39","series-title":"Endocr Rev","first-page":"386","article-title":"Progesterone as a bone-trophic hormone","volume":"11","author":"Prior JC","year":"1990","unstructured":"Prior JC. Progesterone as a bone-trophic hormone. Endocr Rev. 1990;11(2):386\u2013398."},{"issue":"5","key":"b40","series-title":"Clin Endocrinol (Oxf)","first-page":"653","article-title":"Osteoporosis","volume":"33","author":"Compston JE","year":"1990","unstructured":"Compston JE. Osteoporosis. Clin Endocrinol (Oxf). 1990;33(5):653\u2013682."},{"key":"b41","series-title":"Osteoporosis: Etiology, Diagnosis, and Management","first-page":"133","article-title":"Estrogen deficiency","author":"Lindsay R","year":"1990","unstructured":"Lindsay R. Estrogen deficiency. In: Riggs BL, Melton LJ III, eds.Osteoporosis: Etiology, Diagnosis, and Management. 2nd ed. Lippincott-Raven Publishers; 1990:133-160."},{"issue":"1","key":"b42","series-title":"Cold Spring Harb Perspect Med","first-page":"a031211","article-title":"Regulation of bone metabolism by sex steroids","volume":"8","author":"Khosla S","year":"2018","unstructured":"Khosla S, Monroe DG. Regulation of bone metabolism by sex steroids. 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J Clin Endocrinol Metab. 2000;85(10):3496\u20133506."},{"key":"b45","series-title":"Recent Prog Horm Res","first-page":"385","article-title":"Sex steroids and bone","volume":"57","author":"Manolagas SC","year":"2002","unstructured":"Manolagas SC, Kousteni S, Jilka RL. Sex steroids and bone. Recent Prog Horm Res. 2002;57:385\u2013409."},{"issue":"suppl 4","key":"b46","series-title":"Fertil Steril","first-page":"S34","article-title":"Androgen effects on bone and muscle","volume":"77","author":"Notelovitz M","year":"2002","unstructured":"Notelovitz M. Androgen effects on bone and muscle. 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