{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:51:56Z","timestamp":1788375116138,"version":"build-2803163510"},"reference-count":44,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Delayed cerebral ischemia (DCI) is a serious complication of aneurysmal subarachnoid hemorrhage (aSAH), which is responsible for significant death and disability. The dynamic balance between the production and elimination of reactive oxygen species (ROS) in patients with DCI is suspected be shifted to favor ROS formation. The authors assessed the relationship between F2-isoprostanes (F2-IsoPs), oxidative stress biomarkers, and glucose-6-phosphate dehydrogenase (G6PD), which are responsible for nicotinamide adenine dinucleotide phosphate (NADPH) production for glutathione system function, with post-aSAH DCI.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>The authors assessed 45 aSAH patients for F2-IsoP and G6PD concentration using commercial ELISA on days 2, 4, and 6 after aSAH. The authors examined the correlation between plasma F2-IsoP and G6PD concentrations and clinical factors with DCI occurrence and aSAH outcome.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Expectedly, the most important clinical predictors of DCI were Hunt and Hess grade and modified Fisher (mFisher) grade. Plasma F2-IsoP and G6PD concentrations were greater in aSAH patients than the control group (p &lt; 0.01). F2-IsoP concentrations were greater and G6PD concentrations were lower in patients with DCI than those without (p &lt; 0.01). Plasma F2-IsoP and G6PD concentrations on day 2 were correlated with DCI occurrence (p &lt; 0.01). Plasma F2-IsoP concentrations on days 2 and 6 were correlated with outcome at 1 and 12 months (p &lt; 0.01).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Decreased G6PD indirectly informs the reduced antioxidant response, especially for the glutathione system. G6PD concentration was lower in patients with DCI than those without, which may explain the increased F2-IsoP concentrations. mFisher grade, plasma F2-IsoP concentration, and G6PD concentration on day 2 after aSAH, in combination, may serve as predictors of DCI. Further research is necessary to investigate the therapeutic utility of F2-IsoPs and antioxidants in clinical practice.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2022.12.jns222332","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T12:46:57Z","timestamp":1673614017000},"page":"698-707","source":"Crossref","is-referenced-by-count":5,"title":["Glucose-6-phosphate dehydrogenase and 8-iso-prostaglandin F2\u03b1 as potential predictors of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage"],"prefix":"10.3171","volume":"139","author":[{"given":"Karol","family":"Wi\u015bniewski","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia;"},{"name":"Department of Neurosurgery and Neurooncology, Medical University of \u0141\u00f3d\u017a, \u0141\u00f3dzkie, Poland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Pop\u0119da","sequence":"additional","affiliation":[{"name":"Department of Pathomorphology, Medical University of Gda\u0144sk, Pomorskie, Poland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Bie\u0144kowski","sequence":"additional","affiliation":[{"name":"Department of Pathomorphology, Medical University of Gda\u0144sk, Pomorskie, Poland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia;"},{"name":"Department of Medical Sciences, Section of Neurosurgery, Uppsala University, Uppsala, Sweden; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine","family":"Drummond","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia;"},{"name":"Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexios A.","family":"Adamides","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia;"},{"name":"Department of Surgery, Royal Melbourne Hospital, University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"6","key":"b1","series-title":"Neurosurgery","first-page":"1131","article-title":"Characteristics of nontraumatic subarachnoid hemorrhage in the United States in 2003","volume":"61","author":"Shea AM","year":"2007","unstructured":"Shea AM, Reed SD, Curtis LH, Alexander MJ, Villani JJ, Schulman KA. Characteristics of nontraumatic subarachnoid hemorrhage in the United States in 2003. Neurosurgery. 2007;61(6):1131\u20131138."},{"issue":"1","key":"b2","series-title":"Neurology","first-page":"59","article-title":"Time trends in causes of death after aneurysmal subarachnoid hemorrhage: a hospital-based study","volume":"86","author":"Vergouwen MD","year":"2016","unstructured":"Vergouwen MD, Jong-Tjien-Fa AV, Algra A, Rinkel GJ. Time trends in causes of death after aneurysmal subarachnoid hemorrhage: a hospital-based study. Neurology. 2016;86(1):59\u201363."},{"issue":"10","key":"b3","series-title":"CNS Neurosci Ther","first-page":"1096","article-title":"Clinical and experimental aspects of aneurysmal subarachnoid hemorrhage","volume":"25","author":"Daou BJ","year":"2019","unstructured":"Daou BJ, Koduri S, Thompson BG, Chaudhary N, Pandey AS. Clinical and experimental aspects of aneurysmal subarachnoid hemorrhage. CNS Neurosci Ther. 2019;25(10):1096\u20131112."},{"key":"b4","series-title":"Prog Neurobiol","first-page":"64","article-title":"Controversies and evolving new mechanisms in subarachnoid hemorrhage","volume":"115","author":"Chen S","year":"2014","unstructured":"Chen S, Feng H, Sherchan P,  Controversies and evolving new mechanisms in subarachnoid hemorrhage. Prog Neurobiol. 2014;115:64\u201391."},{"issue":"5","key":"b5","series-title":"Neurosurgery","first-page":"753","article-title":"Impairment of vascular reactivity and changes in intracellular calcium and calmodulin levels of smooth muscle cells in canine basilar arteries after subarachnoid hemorrhage","volume":"25","author":"Sakaki S","year":"1989","unstructured":"Sakaki S, Ohue S, Kohno K, Takeda S. Impairment of vascular reactivity and changes in intracellular calcium and calmodulin levels of smooth muscle cells in canine basilar arteries after subarachnoid hemorrhage. Neurosurgery. 1989;25(5):753\u2013761."},{"issue":"2","key":"b6","series-title":"Circ Res","first-page":"416","article-title":"Free radicals mediate actions of oxyhemoglobin on cerebrovascular smooth muscle cells","volume":"68","author":"Steele JA","year":"1991","unstructured":"Steele JA, Stockbridge N, Maljkovic G, Weir B. Free radicals mediate actions of oxyhemoglobin on cerebrovascular smooth muscle cells. Circ Res. 1991;68(2):416\u2013423."},{"issue":"3","key":"b7","series-title":"Can J Neurol Sci","first-page":"326","article-title":"Malondialdehyde, glutathione peroxidase, and superoxide dismutase in cerebrospinal fluid during cerebral vasospasm in monkeys","volume":"19","author":"Macdonald RL","year":"1992","unstructured":"Macdonald RL, Weir BK, Runzer TD, Grace MG. Malondialdehyde, glutathione peroxidase, and superoxide dismutase in cerebrospinal fluid during cerebral vasospasm in monkeys. Can J Neurol Sci. 1992;19(3):326\u2013332."},{"issue":"8","key":"b8","series-title":"Stroke","first-page":"971","article-title":"A review of hemoglobin and the pathogenesis of cerebral vasospasm","volume":"22","author":"Macdonald RL","year":"1991","unstructured":"Macdonald RL, Weir BK. A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke. 1991;22(8):971\u2013982."},{"issue":"1-2","key":"b9","series-title":"Brain Res","first-page":"45","article-title":"Oxidative brain injury from extravasated erythrocytes after intracerebral hemorrhage","volume":"953","author":"Wu J","year":"2002","unstructured":"Wu J, Hua Y, Keep RF, Schallert T, Hoff JT, Xi G. Oxidative brain injury from extravasated erythrocytes after intracerebral hemorrhage. Brain Res. 2002;953(1-2):45\u201352."},{"key":"b10","series-title":"Adv Exp Med Biol","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-030-11488-6_1","article-title":"Diffusion and transport of reactive species across cell membranes","volume":"1127","author":"M\u00f6ller MN","year":"2019","unstructured":"M\u00f6ller MN, Cuevasanta E, Orrico F, Lopez AC, Thomson L, Denicola A. Diffusion and transport of reactive species across cell membranes. Adv Exp Med Biol. 2019;1127:3\u201319."},{"issue":"1-2","key":"b11","series-title":"Free Radic Biol Med","first-page":"202","article-title":"Biomarkers of free radical damage applications in experimental animals and in humans","volume":"26","author":"de Zwart LL","year":"1999","unstructured":"de Zwart LL, Meerman JH, Commandeur JN, Vermeulen NP. Biomarkers of free radical damage applications in experimental animals and in humans. Free Radic Biol Med. 1999;26(1-2):202\u2013226."},{"issue":"1","key":"b12","series-title":"Pediatr Res","first-page":"88","article-title":"Plasma 8-isoprostane is increased in preterm infants who develop bronchopulmonary dysplasia or periventricular leukomalacia","volume":"56","author":"Ahola T","year":"2004","unstructured":"Ahola T, Fellman V, Kjellmer I, Raivio KO, Lapatto R. Plasma 8-isoprostane is increased in preterm infants who develop bronchopulmonary dysplasia or periventricular leukomalacia. Pediatr Res. 2004;56(1):88\u201393."},{"issue":"3","key":"b13","series-title":"Neurol Res","first-page":"301","article-title":"Nonenzymatic derived lipid peroxide, 8-iso-PGF2\u03b1, participates in the pathogenesis of delayed cerebral vasospasm in a canine SAH model","volume":"24","author":"Sakamoto M","year":"2002","unstructured":"Sakamoto M, Takaki E, Yamashita K,  Nonenzymatic derived lipid peroxide, 8-iso-PGF2\u03b1, participates in the pathogenesis of delayed cerebral vasospasm in a canine SAH model. Neurol Res. 2002;24(3):301\u2013306."},{"issue":"24","key":"b14","series-title":"Circulation","first-page":"2833","article-title":"Cardiovascular responses to the isoprostanes iPF2\u03b1-III and iPE2-III are mediated via the thromboxane A2 receptor in vivo","volume":"101","author":"Audoly LP","year":"2000","unstructured":"Audoly LP, Rocca B, Fabre JE,  Cardiovascular responses to the isoprostanes iPF2\u03b1-III and iPE2-III are mediated via the thromboxane A2 receptor in vivo. Circulation. 2000;101(24):2833\u20132840."},{"issue":"4","key":"b15","series-title":"Am J Respir Cell Mol Biol","first-page":"383","article-title":"Isoprostanes and lung vascular pathology","volume":"39","author":"Janssen LJ","year":"2008","unstructured":"Janssen LJ. Isoprostanes and lung vascular pathology. Am J Respir Cell Mol Biol. 2008;39(4):383\u2013389."},{"issue":"6","key":"b16","series-title":"Curr Med Chem","first-page":"703","article-title":"Insights into oxidative stress: the isoprostanes","volume":"14","author":"Montuschi P","year":"2007","unstructured":"Montuschi P, Barnes P, Roberts LJ II. Insights into oxidative stress: the isoprostanes. Curr Med Chem. 2007;14(6):703\u2013717."},{"issue":"1-2","key":"b17","series-title":"FEBS Lett","first-page":"32","article-title":"Metabolism of 8-iso-prostaglandin F2\u03b1","volume":"428","author":"Basu S","year":"1998","unstructured":"Basu S. Metabolism of 8-iso-prostaglandin F2\u03b1. FEBS Lett. 1998;428(1-2):32\u201336."},{"issue":"5","key":"b18","series-title":"Biochim Biophys Acta","first-page":"3217","article-title":"Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes","volume":"1830","author":"Deponte M","year":"2013","unstructured":"Deponte M. Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes. Biochim Biophys Acta. 2013;1830(5):3217\u20133266."},{"key":"b19","first-page":"5529256","article-title":"The controversial role of glucose-6-phosphate dehydrogenase deficiency on cardiovascular disease: a narrative review. Oxid Med Cell Longev","volume":"2021","author":"Dore MP","year":"2021","unstructured":"Dore MP, Parodi G, Portoghese M, Pes GM. The controversial role of glucose-6-phosphate dehydrogenase deficiency on cardiovascular disease: a narrative review. Oxid Med Cell Longev. 2021;2021:5529256."},{"issue":"3","key":"b20","series-title":"Arterioscler Thromb Vasc Biol","first-page":"411","article-title":"Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxide","volume":"23","author":"Leopold JA","year":"2003","unstructured":"Leopold JA, Zhang YY, Scribner AW, Stanton RC, Loscalzo J. Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxide. Arterioscler Thromb Vasc Biol. 2003;23(3):411\u2013417."},{"issue":"2","key":"b21","series-title":"Hypertension","first-page":"523","article-title":"CRISPR-mediated single nucleotide polymorphism modeling in rats reveals insight into reduced cardiovascular risk associated with Mediterranean G6PD variant","volume":"76","author":"Kitagawa A","year":"2020","unstructured":"Kitagawa A, Kizub I, Jacob C,  CRISPR-mediated single nucleotide polymorphism modeling in rats reveals insight into reduced cardiovascular risk associated with Mediterranean G6PD variant. Hypertension. 2020;76(2):523\u2013532."},{"issue":"10","key":"b22","series-title":"FASEB J","first-page":"1771","article-title":"Glucose-6-phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothelial nitric oxide bioavailability","volume":"15","author":"Leopold JA","year":"2001","unstructured":"Leopold JA, Cap A, Scribner AW, Stanton RC, Loscalzo J. Glucose-6-phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothelial nitric oxide bioavailability. FASEB J. 2001;15(10):1771\u20131773."},{"key":"b23","series-title":"Free Radic Biol Med","first-page":"433","article-title":"G6PD plays a neuroprotective role in brain ischemia through promoting pentose phosphate pathway","volume":"112","author":"Cao L","year":"2017","unstructured":"Cao L, Zhang D, Chen J,  G6PD plays a neuroprotective role in brain ischemia through promoting pentose phosphate pathway. Free Radic Biol Med. 2017;112:433\u2013444."},{"issue":"1","key":"b24","series-title":"Arch Biochem Biophys","first-page":"160","article-title":"Comparison of formation of D2\/E2-isoprostanes and F2-isoprostanes in vitro and in vivo\u2014effects of oxygen tension and glutathione","volume":"353","author":"Morrow JD","year":"1998","unstructured":"Morrow JD, Roberts LJ, Daniel VC,  Comparison of formation of D2\/E2-isoprostanes and F2-isoprostanes in vitro and in vivo\u2014effects of oxygen tension and glutathione. Arch Biochem Biophys. 1998;353(1):160\u2013171."},{"issue":"1","key":"b25","series-title":"Int J Dev Neurosci","first-page":"9","article-title":"Caffeic acid phenethyl ester (CAPE) attenuates cerebral vasospasm after experimental subarachnoidal haemorrhage by increasing brain nitric oxide levels","volume":"24","author":"Aladag MA","year":"2006","unstructured":"Aladag MA, Turkoz Y, Ozcan C,  Caffeic acid phenethyl ester (CAPE) attenuates cerebral vasospasm after experimental subarachnoidal haemorrhage by increasing brain nitric oxide levels. Int J Dev Neurosci. 2006;24(1):9\u201314."},{"issue":"11","key":"b26","series-title":"Neurochem Res","first-page":"1935","article-title":"Melatonin ameliorates cerebral vasospasm after experimental subarachnoidal haemorrhage correcting imbalance of nitric oxide levels in rats","volume":"34","author":"Aladag MA","year":"2009","unstructured":"Aladag MA, Turkoz Y, Parlakpinar H, Ozen H, Egri M, Unal SC. Melatonin ameliorates cerebral vasospasm after experimental subarachnoidal haemorrhage correcting imbalance of nitric oxide levels in rats. Neurochem Res. 2009;34(11):1935\u20131944."},{"issue":"2","key":"b27","series-title":"J Med Life","first-page":"120","article-title":"Subarachnoid hemorrhage and cerebral vasospasm\u2014literature review","volume":"6","author":"Ciurea AV","year":"2013","unstructured":"Ciurea AV, Palade C, Voinescu D, Nica DA. Subarachnoid hemorrhage and cerebral vasospasm\u2014literature review. J Med Life. 2013;6(2):120\u2013125."},{"key":"b28","series-title":"Front Biosci","first-page":"3288","article-title":"Oxidative stress in neurodegeneration and available means of protection","volume":"13","author":"Fatokun AA","year":"2008","unstructured":"Fatokun AA, Stone TW, Smith RA. Oxidative stress in neurodegeneration and available means of protection. Front Biosci. 2008;13:3288\u20133311."},{"issue":"6","key":"b29","series-title":"Diabetes","first-page":"1446","article-title":"Oxidative stress as a major culprit in kidney disease in diabetes","volume":"57","author":"Forbes JM","year":"2008","unstructured":"Forbes JM, Coughlan MT, Cooper ME. Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes. 2008;57(6):1446\u20131454."},{"issue":"16","key":"b30","series-title":"Circulation","first-page":"1536","article-title":"Elevated levels of 8-iso-prostaglandin F2\u03b1 in pericardial fluid of patients with heart failure: a potential role for in vivo oxidant stress in ventricular dilatation and progression to heart failure","volume":"97","author":"Mallat Z","year":"1998","unstructured":"Mallat Z, Philip I, Lebret M, Chatel D, Maclouf J, Tedgui A. Elevated levels of 8-iso-prostaglandin F2\u03b1 in pericardial fluid of patients with heart failure: a potential role for in vivo oxidant stress in ventricular dilatation and progression to heart failure. Circulation. 1998;97(16):1536\u20131539."},{"issue":"1-2","key":"b31","series-title":"Anal Biochem","first-page":"126","article-title":"A significant proportion of F2-isoprostanes in human urine are excreted as glucuronide conjugates","volume":"403","author":"Yan Z","year":"2010","unstructured":"Yan Z, Mas E, Mori TA, Croft KD, Barden AE. A significant proportion of F2-isoprostanes in human urine are excreted as glucuronide conjugates. Anal Biochem. 2010;403(1-2):126\u2013128."},{"issue":"18","key":"b32","series-title":"N Engl J Med","first-page":"1198","article-title":"Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage","volume":"332","author":"Morrow JD","year":"1995","unstructured":"Morrow JD, Frei B, Longmire AW,  Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. N Engl J Med. 1995;332(18):1198\u20131203."},{"issue":"6","key":"b33","series-title":"J Neurosurg","first-page":"1914","article-title":"Clinical prediction of delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage","volume":"130","author":"Lee H","year":"2019","unstructured":"Lee H, Perry JJ, English SW,  Clinical prediction of delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage. J Neurosurg. 2019;130(6):1914\u20131921."},{"issue":"2","key":"b34","series-title":"Brain Pathol","first-page":"149","article-title":"Cyclopentenone eicosanoids as mediators of neurodegeneration: a pathogenic mechanism of oxidative stress-mediated and cyclooxygenase-mediated neurotoxicity","volume":"15","author":"Musiek ES","year":"2005","unstructured":"Musiek ES, Milne GL, McLaughlin B, Morrow JD. Cyclopentenone eicosanoids as mediators of neurodegeneration: a pathogenic mechanism of oxidative stress-mediated and cyclooxygenase-mediated neurotoxicity. Brain Pathol. 2005;15(2):149\u2013158."},{"issue":"3","key":"b35","series-title":"Free Radic Biol Med","first-page":"247","article-title":"F2-isoprostanes are not just markers of oxidative stress","volume":"44","author":"Comporti M","year":"2008","unstructured":"Comporti M, Signorini C, Arezzini B, Vecchio D, Monaco B, Gardi C. F2-isoprostanes are not just markers of oxidative stress. Free Radic Biol Med. 2008;44(3):247\u2013256."},{"issue":"3","key":"b36","series-title":"Neurosci Lett","first-page":"222","article-title":"A non-enzymatic derived arachidonyl peroxide, 8-iso-prostaglandin F2\u03b1, in cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage participates in the pathogenesis of delayed cerebral vasospasm","volume":"373","author":"Asaeda M","year":"2005","unstructured":"Asaeda M, Sakamoto M, Kurosaki M,  A non-enzymatic derived arachidonyl peroxide, 8-iso-prostaglandin F2\u03b1, in cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage participates in the pathogenesis of delayed cerebral vasospasm. Neurosci Lett. 2005;373(3):222\u2013225."},{"issue":"6","key":"b37","series-title":"Free Radic Biol Med","first-page":"814","article-title":"Correlation of F4-neuroprostanes levels in cerebrospinal fluid with outcome of aneurysmal subarachnoid hemorrhage in humans","volume":"47","author":"Hsieh YP","year":"2009","unstructured":"Hsieh YP, Lin CL, Shiue AL,  Correlation of F4-neuroprostanes levels in cerebrospinal fluid with outcome of aneurysmal subarachnoid hemorrhage in humans. Free Radic Biol Med. 2009;47(6):814\u2013824."},{"issue":"2","key":"b38","series-title":"FASEB J","first-page":"174","article-title":"Glucose-6-phosphate dehydrogenase: a \"housekeeping\" enzyme subject to tissue-specific regulation by hormones, nutrients, and oxidant stress","volume":"8","author":"Kletzien RF","year":"1994","unstructured":"Kletzien RF, Harris PK, Foellmi LA. Glucose-6-phosphate dehydrogenase: a \"housekeeping\" enzyme subject to tissue-specific regulation by hormones, nutrients, and oxidant stress. FASEB J. 1994;8(2):174\u2013181."},{"issue":"1","key":"b39","series-title":"Acta Neurol Scand","first-page":"62","article-title":"Antioxidant enzymatic activities after experimental subarachnoid hemorrhage in rats","volume":"87","author":"Marzatico F","year":"1993","unstructured":"Marzatico F, Gaetani P, Caf\u00e8 C, Spanu G, Rodriguez y Baena R. Antioxidant enzymatic activities after experimental subarachnoid hemorrhage in rats. Acta Neurol Scand. 1993;87(1):62\u201366."},{"issue":"2","key":"b40","series-title":"Neurol Res","first-page":"195","article-title":"Glutathione peroxidase and subarachnoid hemorrhage: implications for the role of oxidative stress in cerebral vasospasm","volume":"31","author":"Pyne-Geithman GJ","year":"2009","unstructured":"Pyne-Geithman GJ, Caudell DN, Prakash P, Clark JF. Glutathione peroxidase and subarachnoid hemorrhage: implications for the role of oxidative stress in cerebral vasospasm. Neurol Res. 2009;31(2):195\u2013199."},{"issue":"10","key":"b41","series-title":"Stroke","first-page":"2391","article-title":"Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group","volume":"41","author":"Vergouwen MD","year":"2010","unstructured":"Vergouwen MD, Vermeulen M, van Gijn J,  Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke. 2010;41(10):2391\u20132395."},{"issue":"12","key":"b42","series-title":"Clin Chem","first-page":"2415","article-title":"Enzyme immunoassay (EIA)\/enzyme-linked immunosorbent assay (ELISA)","volume":"51","author":"Lequin RM","year":"2005","unstructured":"Lequin RM. Enzyme immunoassay (EIA)\/enzyme-linked immunosorbent assay (ELISA). Clin Chem. 2005;51(12):2415\u20132418."},{"issue":"1","key":"b43","series-title":"J Biomed Lab Sci","first-page":"1","article-title":"Detection of F2-isoprostanes and F4-neuroprostanes in clinical studies","volume":"22","author":"Yen HC","year":"2010","unstructured":"Yen HC. Detection of F2-isoprostanes and F4-neuroprostanes in clinical studies. J Biomed Lab Sci. 2010;22(1):1\u201311."},{"issue":"7","key":"b44","series-title":"J High Resolut Chromatogr","first-page":"461","article-title":"Practical limitations of capillary gas chromatography","volume":"2","author":"Schomburg G","year":"1979","unstructured":"Schomburg G. Practical limitations of capillary gas chromatography. J High Resolut Chromatogr. 1979;2(7):461\u2013474."}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/139\/3\/article-p698.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/139\/3\/article-p698.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/139\/3\/article-p698.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T10:52:25Z","timestamp":1716029545000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/139\/3\/article-p698.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,1]]},"references-count":44,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/2022.12.jns222332","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,1]]}}}