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Primary and secondary outcome measures were return to normal bowel function, including time to passage of flatus and stool, time to tolerance of oral nutrition, and time to hospital discharge. Patients were included regardless of chronic opioid consumption status.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Thirty-one patients provided consent for participation, and 26 patients (13 per group) completed the study. There were no differences between groups with respect to time to flatus, time to bowel movement, time to oral nutrition tolerance, and time to discharge. Calculated effect sizes favored placebo for all interventions.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Alvimopan did not hasten return to bowel function for any primary or secondary outcome measures when compared with placebo for patients undergoing PSF. There were no adverse events related to alvimopan, including for patients with chronic opioid consumption. While underpowered to determine a statistical difference, it is unlikely that a clinically relevant effect exists.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2022.2.spine211551","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T17:53:33Z","timestamp":1650995613000},"page":"446-451","source":"Crossref","is-referenced-by-count":1,"title":["Alvimopan for the reduction of postoperative ileus after long posterior spinal fusion: placebo-controlled double-blind randomized trial"],"prefix":"10.3171","volume":"37","author":[{"given":"Eric","family":"Feuchtbaum","sequence":"first","affiliation":[{"name":"OrthoBethesda, Bethesda, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P.","family":"Wondra","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, Missouri;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Bumpass","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, University of Arkansas Medical School, Little Rock, Arkansas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas P.","family":"Zebala","sequence":"additional","affiliation":[{"name":"NorthShore University, Evanston, Illinois;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence G.","family":"Lenke","sequence":"additional","affiliation":[{"name":"Columbia University College of Physicians and Surgeons, The Och Spine Hospital, New York, New York; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Rady Children\u2019s Hospital, University of California, San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"2","key":"b1","series-title":"Drugs Aging","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2165\/11586170-000000000-00000","article-title":"Epidemiology, pathophysiology and medical management of postoperative ileus in the elderly","volume":"28","author":"Hiranyakas A","year":"2011","unstructured":"Hiranyakas A, Bashankaev B, Seo CJ, Khaikin M, Wexner SD. 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