{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:28:05Z","timestamp":1766050085981,"version":"3.28.0"},"reference-count":26,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Because of the aggressive nature of glioblastoma, patients with unresected disease are encouraged to begin radiotherapy within approximately 1 month after craniotomy. The aim of this study was to investigate the potential association between time interval from biopsy to radiotherapy with overall survival in patients with unresected glioblastoma.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Patients with unresected glioblastoma diagnosed between 2010 and 2014 who received adjuvant radiotherapy and concurrent chemotherapy were identified in the National Cancer Database. Demographic and clinical data were compared using chi-square and Wilcoxon rank-sum tests. Survival was analyzed using the Kaplan-Meier method and Cox proportional hazards regression modeling.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Among 3456 patients with unresected glioblastoma, initiation of radiotherapy within 3 weeks of biopsy was associated with a higher hazard of death compared with later initiation of radiotherapy. After excluding patients who received radiotherapy within 3 weeks of biopsy to minimize the effects of confounders associated with short time intervals from biopsy to radiotherapy, the median interval from biopsy to radiotherapy was 32 days (IQR 27\u201339 days). Overall, 1782 (66.82%) patients started radiotherapy within 5 weeks of biopsy, and 885 (33.18%) patients started radiotherapy beyond 5 weeks of biopsy. On multivariable analysis, there was no significant difference in overall survival between these two groups (HR 0.96, 95% CI 0.88\u20131.50; p = 0.374).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>In patients with unresected glioblastoma, a longer time interval from biopsy to radiotherapy does not appear to be associated with worse overall survival. However, external validation of these findings is necessary given that selection bias is a significant limitation of this study.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2022.5.jns212761","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T13:07:25Z","timestamp":1659704845000},"page":"610-620","source":"Crossref","is-referenced-by-count":4,"title":["Impact of radiotherapy delay following biopsy for patients with unresected glioblastoma"],"prefix":"10.3171","volume":"138","author":[{"given":"Sarah","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Therapeutic Radiology, Yale School of Medicine, New Haven;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yale School of Medicine, New Haven;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Moliterno","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yale School of Medicine, New Haven;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary A.","family":"Corbin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yale School of Medicine, New Haven;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjit S.","family":"Bindra","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Radiology, Yale School of Medicine, New Haven;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph N.","family":"Contessa","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Radiology, Yale School of Medicine, New Haven;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Yu","sequence":"additional","affiliation":[{"name":"Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale School of Medicine, New Haven, Connecticut; and"},{"name":"Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry S.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Radiology, Yale School of Medicine, New Haven;"},{"name":"Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale School of Medicine, New Haven, Connecticut; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"Brain Sci","first-page":"15","article-title":"Glioblastoma under siege: an overview of current therapeutic strategies","volume":"8","author":"Paolillo M","year":"2018","unstructured":"Paolillo M, Boselli C, Schinelli S. 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N Engl J Med. 2005;352(10):987\u2013996.15758009"},{"issue":"5","key":"b4","series-title":"Lancet Oncol","first-page":"459","article-title":"Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial","volume":"10","author":"Stupp R","year":"2009","unstructured":"Stupp R, Hegi ME, Mason WP,  Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009;10(5):459\u2013466."},{"issue":"5 suppl","key":"b5","series-title":"Clin J Oncol Nurs","first-page":"S2","article-title":"Glioblastoma: overview of disease and treatment","volume":"20","author":"Davis ME","year":"2016","unstructured":"Davis ME. Glioblastoma: overview of disease and treatment. Clin J Oncol Nurs. 2016;20(5 suppl):S2\u2013S8.27668386"},{"key":"b6","series-title":"De Vleeschouwer S, ed. Glioblastoma [Internet]","article-title":"Glioblastoma genomics: a very complicated story","author":"Lombardi MY","year":"2017","unstructured":"Lombardi MY, Assem M. Glioblastoma genomics: a very complicated story. In: De Vleeschouwer S, ed. Glioblastoma [Internet]. Codon Publications;2017.Chapter 1. Accessed June 1, 2022.https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470004\/"},{"key":"b7","series-title":"J Clin Neurosci","first-page":"7","article-title":"Ten-year survival in glioblastoma. A systematic review","volume":"54","author":"Tykocki T","year":"2018","unstructured":"Tykocki T, Eltayeb M. Ten-year survival in glioblastoma. A systematic review. J Clin Neurosci. 2018;54:7\u201313.29801989"},{"issue":"10","key":"b8","series-title":"Lancet Oncol","first-page":"1373","article-title":"Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial","volume":"18","author":"Weller M","year":"2017","unstructured":"Weller M, Butowski N, Tran DD,  Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial. Lancet Oncol. 2017;18(10):1373\u20131385."},{"issue":"15","key":"b9","series-title":"Cancer","first-page":"2364","article-title":"Concurrent chemoradiotherapy versus radiotherapy alone for \"biopsy-only\" glioblastoma multiforme","volume":"122","author":"Kole AJ","year":"2016","unstructured":"Kole AJ, Park HS, Yeboa DN,  Concurrent chemoradiotherapy versus radiotherapy alone for \"biopsy-only\" glioblastoma multiforme. Cancer. 2016;122(15):2364\u20132370.27172136"},{"issue":"12","key":"b10","series-title":"Clin Transl Oncol","first-page":"797","article-title":"Clinical course of high-grade glioma patients with a \"biopsy-only\" surgical approach: a need for individualised treatment","volume":"9","author":"Bala\u00f1a C","year":"2007","unstructured":"Bala\u00f1a C, Capellades J, Teixidor P,  Clinical course of high-grade glioma patients with a \"biopsy-only\" surgical approach: a need for individualised treatment. Clin Transl Oncol. 2007;9(12):797\u2013803.18158984"},{"issue":"5","key":"b11","series-title":"J Neurosurg","first-page":"1144","article-title":"Survival impact of time to initiation of chemoradiotherapy after resection of newly diagnosed glioblastoma","volume":"122","author":"Sun MZ","year":"2015","unstructured":"Sun MZ, Oh T, Ivan ME,  Survival impact of time to initiation of chemoradiotherapy after resection of newly diagnosed glioblastoma. J Neurosurg. 2015;122(5):1144\u20131150.25768833"},{"issue":"3","key":"b12","series-title":"Ann Surg Oncol","first-page":"683","article-title":"The National Cancer Data Base: a powerful initiative to improve cancer care in the United States","volume":"15","author":"Bilimoria KY","year":"2008","unstructured":"Bilimoria KY, Stewart AK, Winchester DP, Ko CY. The National Cancer Data Base: a powerful initiative to improve cancer care in the United States. Ann Surg Oncol. 2008;15(3):683\u2013690."},{"issue":"1","key":"b13","series-title":"J BUON","first-page":"173","article-title":"Factors affecting the survival of patients with glioblastoma multiforme","volume":"23","author":"Nikolov V","year":"2018","unstructured":"Nikolov V, Stojanovic M, Kostic A,  Factors affecting the survival of patients with glioblastoma multiforme. 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Int J Radiat Oncol Biol Phys. 1993;26(2):239\u2013244.8387988"},{"issue":"6","key":"b15","series-title":"Neuro Oncol","first-page":"868","article-title":"Biopsy versus partial versus gross total resection in older patients with high-grade glioma: a systematic review and meta-analysis","volume":"17","author":"Almenawer SA","year":"2015","unstructured":"Almenawer SA, Badhiwala JH, Alhazzani W,  Biopsy versus partial versus gross total resection in older patients with high-grade glioma: a systematic review and meta-analysis. Neuro Oncol. 2015;17(6):868\u2013881.25556920"},{"issue":"4","key":"b16","series-title":"Neurooncol Pract","first-page":"248","article-title":"Acute care in glioblastoma: the burden and the consequences","volume":"4","author":"Wasilewski A","year":"2017","unstructured":"Wasilewski A, Serventi J, Kamalyan L, Wychowski T, Mohile N. Acute care in glioblastoma: the burden and the consequences. Neurooncol Pract. 2017;4(4):248\u2013254.31385967"},{"issue":"2","key":"b17","series-title":"J Neurooncol","first-page":"325","article-title":"Early initiation of chemoradiation following index craniotomy is associated with decreased survival in high-grade glioma","volume":"135","author":"Nathan JK","year":"2017","unstructured":"Nathan JK, Brezzell AL, Kim MM, Leung D, Wilkinson DA, Hervey-Jumper SL. Early initiation of chemoradiation following index craniotomy is associated with decreased survival in high-grade glioma. J Neurooncol. 2017;135(2):325\u2013333.28744829"},{"issue":"2","key":"b18","first-page":"93","article-title":"Mathematical modelling of survival of glioblastoma patients suggests a role for radiotherapy dose escalation and predicts poorer outcome after delay to start treatment","volume":"18","author":"Burnet NG","year":"2006","unstructured":"Burnet NG, Jena R, Jefferies SJ, Stenning SP, Kirkby NF. Mathematical modelling of survival of glioblastoma patients suggests a role for radiotherapy dose escalation and predicts poorer outcome after delay to start treatment. Clin Oncol (R Coll Radiol).2006;18(2):93\u2013103.16523808"},{"issue":"3","key":"b19","series-title":"Neuropathol Appl Neurobiol","first-page":"271","article-title":"Review: molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies","volume":"38","author":"Masui K","year":"2012","unstructured":"Masui K, Cloughesy TF, Mischel PS. Review: molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies. Neuropathol Appl Neurobiol. 2012;38(3):271\u2013291.22098029"},{"issue":"2","key":"b20","series-title":"J Neurooncol","first-page":"357","article-title":"Temporal relationship of post-operative radiotherapy with temozolomide and oncologic outcome for glioblastoma","volume":"116","author":"Spratt DE","year":"2014","unstructured":"Spratt DE, Folkert M, Zumsteg ZS,  Temporal relationship of post-operative radiotherapy with temozolomide and oncologic outcome for glioblastoma. J Neurooncol. 2014;116(2):357\u2013363.24190580"},{"issue":"5","key":"b21","series-title":"Neurosurgery","first-page":"915","article-title":"Impact of timing of adjuvant chemoradiation for glioblastoma in a large hospital database","volume":"83","author":"Osborn VW","year":"2018","unstructured":"Osborn VW, Lee A, Garay E, Safdieh J, Schreiber D. Impact of timing of adjuvant chemoradiation for glioblastoma in a large hospital database. Neurosurgery. 2018;83(5):915\u2013921."},{"issue":"1","key":"b22","series-title":"Radiat Oncol","first-page":"172","article-title":"Impact of waiting time after surgery and overall time of postoperative radiochemotherapy on treatment outcome in glioblastoma multiforme","volume":"10","author":"Seidlitz A","year":"2015","unstructured":"Seidlitz A, Siepmann T, L\u00f6ck S, Juratli T, Baumann M, Krause M. Impact of waiting time after surgery and overall time of postoperative radiochemotherapy on treatment outcome in glioblastoma multiforme. Radiat Oncol. 2015;10(1):172.26276734"},{"key":"b23","series-title":"Clin Neurol Neurosurg","first-page":"73","article-title":"Impact of timing of radiotherapy in patients with newly diagnosed glioblastoma","volume":"151","author":"Randolph DM II","year":"2016","unstructured":"Randolph DM II, McTyre ER, Paulsson AK,  Impact of timing of radiotherapy in patients with newly diagnosed glioblastoma. Clin Neurol Neurosurg. 2016;151:73\u201378.27816029"},{"issue":"2","key":"b24","series-title":"Neuro Oncol","first-page":"190","article-title":"The timing of cranial radiation in elderly patients with newly diagnosed glioblastoma multiforme","volume":"12","author":"Lai R","year":"2010","unstructured":"Lai R, Hershman DL, Doan T, Neugut AI. The timing of cranial radiation in elderly patients with newly diagnosed glioblastoma multiforme. Neuro Oncol. 2010;12(2):190\u2013198.20150386"},{"issue":"7","key":"b25","series-title":"Neuro Oncol","first-page":"966","article-title":"Short delay in initiation of radiotherapy for patients with glioblastoma-effect of concurrent chemotherapy: a secondary analysis from the NRG Oncology\/Radiation Therapy Oncology Group database","volume":"20","author":"Blumenthal DT","year":"2018","unstructured":"Blumenthal DT, Won M, Mehta MP,  Short delay in initiation of radiotherapy for patients with glioblastoma-effect of concurrent chemotherapy: a secondary analysis from the NRG Oncology\/Radiation Therapy Oncology Group database. 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