{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:58:14Z","timestamp":1778875094801,"version":"3.51.4"},"reference-count":45,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Thalamotomy at the nucleus ventralis intermedius using MR-guided focused ultrasound has been an effective treatment method for essential tremor (ET). However, this is not true for all cases, even for successful ablation. How the brain differs in patients with ET between those with long-term good and poor outcomes is not clear. To analyze the functional connectivity difference between patients in whom thalamotomy was effective and those in whom thalamotomy was ineffective and its prognostic role in ET treatment, the authors evaluated preoperative resting-state functional MRI in thalamotomy-treated patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Preoperative resting-state functional MRI data in 85 patients with ET, who were experiencing tremor relief at the time of treatment and were followed up for a minimum of 6 months after the procedure, were collected for the study. The authors conducted a graph independent component analysis of the functional connectivity matrices of tremor-related networks. The patients were divided into thalamotomy-effective and thalamotomy-ineffective groups (thalamotomy-effective group, \u2265 50% motor symptom reduction; thalamotomy-ineffective group, &lt; 50% motor symptom reduction at 6 months after treatment) and the authors compared network components between groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Seventy-two (84.7%) of the 85 patients showed \u2265 50% tremor reduction from baseline at 6 months after thalamotomy. The network analysis shows significant suppression of functional network components with connections between the areas of the cerebellum and the basal ganglia and thalamus, but enhancement of those between the premotor cortex and supplementary motor area in the noneffective group compared to the effective group.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>The present study demonstrates that patients in the noneffective group have suppressed functional subnetworks in the cerebellum and subcortex regions and have enhanced functional subnetworks among motor-sensory cortical networks compared to the thalamotomy-effective group. Therefore, the authors suggest that the functional connectivity pattern might be a possible predictive factor for outcomes of MR-guided focused ultrasound thalamotomy.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2022.5.jns22324","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T12:32:42Z","timestamp":1658493162000},"page":"318-328","source":"Crossref","is-referenced-by-count":7,"title":["Differences in intrinsic functional networks in patients with essential tremor who had good and poor long-term responses after thalamotomy performed using MR-guided ultrasound"],"prefix":"10.3171","volume":"138","author":[{"given":"Chongwon","family":"Pae","sequence":"first","affiliation":[{"name":"Center for Systems and Translational Brain Sciences, Institute of Human Complexity and Systems Science, Yonsei University, Seoul;"},{"name":"Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul;"},{"name":"Department of Psychiatry, Bundang CHA Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Korea University College of Medicine, Korea University Medical Center, Ansan Hospital, Gyeonggi-do;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Seok","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"},{"name":"Center for Innovative Functional Neurosurgery, Brain Research Institute, Seoul;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Ho","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"},{"name":"Center for Innovative Functional Neurosurgery, Brain Research Institute, Seoul;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Won","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinseok","family":"Eo","sequence":"additional","affiliation":[{"name":"Center for Systems and Translational Brain Sciences, Institute of Human Complexity and Systems Science, Yonsei University, Seoul;"},{"name":"Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul;"},{"name":"Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae-Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Systems and Translational Brain Sciences, Institute of Human Complexity and Systems Science, Yonsei University, Seoul;"},{"name":"Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul;"},{"name":"Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul;"},{"name":"Department of Cognitive Science, Yonsei University, Seoul; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Woo","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"},{"name":"Center for Innovative Functional Neurosurgery, Brain Research Institute, Seoul;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"Mov Disord","first-page":"5","article-title":"How common is the most common adult movement disorder? estimates of the prevalence of essential tremor throughout the world","volume":"13","author":"Louis ED","year":"1998","unstructured":"Louis ED, Ottman R, Hauser WA. 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