{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T03:11:49Z","timestamp":1786590709512,"version":"build-2736575974"},"reference-count":45,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Incidental, asymptomatic pituitary adenomas require nuanced, shared decision-making, which is limited by a poor understanding of their natural history and effects on quality of life (QOL). A greater understanding of the effects of surgery would inform evidence-based care.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>A multicenter review of consecutive pituitary adenomas resected via an endoscopic endonasal approach (EEA) between late 2016 and mid-2021 was performed, with prospective, longitudinal QOL assessment (at 3 and 6 weeks and at 3, 6, and 12 months) postoperatively using the 35-item Anterior Skull Base Questionnaire.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Of 366 adenomas resected during the study period, 52 (14.2%) were incidentally discovered, of which 51 (98.1%) were macroadenomas. Preoperative QOL in patients with these incidentalomas was better than in those with adenomas presenting with endocrinopathy (p &lt; 0.01), visual failure (p = 0.02), or headache (p = 0.03). Surgery was performed due to visual field deficits (13.5%, n = 7); ophthalmoplegia (1.9%, n = 1); radiological compression or contact of the optic apparatus (63.5%, n = 33); functional status (growth hormone\u2013secreting tumor) (5.8%, n = 3); and clinically significant growth (15.4%, n = 8). Surgical outcomes were excellent, with vision improved in 100% (7\/7) and complete resection in 84.6% (44\/52). There were 2 (3.8%) cases of new cortisol deficiency, 3 (5.8%) cases of transient postoperative diabetes insipidus, and 4 (7.7%) cases of postoperative hyponatremia. There were no perioperative complications and no cases of postoperative CSF leakage. QOL transiently decreased during the first 3 weeks after surgery, then improved to above baseline levels by 3 months (p = 0.03) and continued to improve throughout the first postoperative year (p = 0.03). All surgical indications demonstrated an overall mean improvement in QOL at 3 months. QOL benefits were not affected by age or tumor size.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Resection of pituitary adenomas via the EEA provided a tangible benefit for patients within 3 months. Surgery via the EEA is safe, effective, and beneficial for patients with pituitary incidentalomas meeting accepted criteria for intervention.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2022.5.jns2286","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T19:27:48Z","timestamp":1657308468000},"page":"567-573","source":"Crossref","is-referenced-by-count":17,"title":["Quality of life and surgical outcomes in incidental pituitary adenomas undergoing endoscopic endonasal resection"],"prefix":"10.3171","volume":"138","author":[{"given":"Mendel","family":"Castle-Kirszbaum","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Monash Health, Melbourne;"},{"name":"Department of Surgery, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Yuen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, St. Vincent\u2019s Health, Melbourne;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"King","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Royal Melbourne Hospital, Melbourne; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Kam","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Monash Health, Melbourne;"},{"name":"Department of Neurosurgery, Royal Melbourne Hospital, Melbourne; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Goldschlager","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Monash Health, Melbourne;"},{"name":"Department of Surgery, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"9","key":"b1","series-title":"J Clin Endocrinol Metab","first-page":"4268","article-title":"Incidence of pituitary adenomas in Northern Finland in 1992-2007","volume":"95","author":"Raappana A","year":"2010","unstructured":"Raappana A, Koivukangas J, Ebeling T, Piril\u00e4 T. 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