{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:50:49Z","timestamp":1790617849082,"version":"4.1.0"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The hemodynamics of a brain arteriovenous malformation (AVM) nidus may be closely related to clinical presentation. The authors of this study aimed to explore the hemorrhagic quantitative hemodynamic indicators of the nidus through quantitative digital subtraction angiography (QDSA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The quantitative hemodynamic parameters were generated from QDSA. Three data sets were used to explore independent quantitative hemodynamic indicators associated with AVM rupture. The training data set was exploited to discover independent quantitative hemodynamic indicators of AVM rupture by performing univariate and multivariate logistic regression analyses. The authors plotted receiver operating characteristic curves to validate the diagnostic performance of the hemorrhagic hemodynamic indicators using the training and two external validation data sets. Kaplan-Meier survival analysis was adopted to verify the predictive power of these risk indicators of future hemorrhage in the external prospective validation data set.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 151 patients were included in this study, 91 in the training set and 30 in each of the two validation sets. A higher stasis index and slower transnidal relative velocity (TRV) of the nidus were significantly correlated with AVM rupture. The areas under the curve (AUCs) of the stasis index (nidus) were 0.765 and 0.815 and those of the TRV (nidus) were 0.735 and 0.796, respectively, in the training and retrospective external validation sets. Kaplan-Meier survival analysis confirmed the validity of the stasis index and TRV in predicting future rupture risk in the prospective validation data set (p = 0.008 and 0.041, respectively, log-rank test).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>A higher stasis index (nidus) and slower TRV (nidus) in QDSA were associated with AVM rupture and were effective indicators of future hemorrhage, suggesting that the core mechanisms underlying AVM rupture could be intravascular blood stasis and occlusive hyperemia of the nidus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2022.6.jns212818","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T14:42:21Z","timestamp":1665585741000},"page":"740-749","source":"Crossref","is-referenced-by-count":21,"title":["Rupture-related quantitative hemodynamics of the supratentorial arteriovenous malformation nidus"],"prefix":"10.3171","volume":"138","author":[{"given":"Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingting","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Energy and Power Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruinan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heze","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengwei","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youxiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"},{"name":"Department of Neurosurgery, Peking University International Hospital, Peking University, Beijing; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing;"},{"name":"Department of Neurosurgery, Peking University International Hospital, Peking University, Beijing; and"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"Nat Rev Dis Primers","first-page":"15008","article-title":"Brain arteriovenous malformations","volume":"1","author":"Lawton MT","year":"2015","unstructured":"Lawton MT, Rutledge WC, Kim H,  Brain arteriovenous malformations. Nat Rev Dis Primers. 2015;1(1):15008.27188382"},{"issue":"Pt 10","key":"b2","series-title":"Brain","first-page":"1900","article-title":"A systematic review of the frequency and prognosis of arteriovenous malformations of the brain in adults","volume":"124","author":"Al-Shahi R","year":"2001","unstructured":"Al-Shahi R, Warlow C. A systematic review of the frequency and prognosis of arteriovenous malformations of the brain in adults. Brain. 2001;124(Pt 10):1900\u2013192611571210"},{"issue":"16","key":"b3","series-title":"JAMA","first-page":"1661","article-title":"Outcome after conservative management or intervention for unruptured brain arteriovenous malformations","volume":"311","author":"Al-Shahi Salman R","year":"2014","unstructured":"Al-Shahi Salman R, White PM, Counsell CE,  Outcome after conservative management or intervention for unruptured brain arteriovenous malformations. JAMA. 2014;311(16):1661\u20131669."},{"issue":"3","key":"b4","series-title":"Neurosurgery","first-page":"548","article-title":"Treatment outcomes of a randomized trial of unruptured brain arteriovenous malformation-eligible unruptured brain arteriovenous malformation patients","volume":"83","author":"Lang M","year":"2018","unstructured":"Lang M, Moore NZ, Rasmussen PA, Bain MD. Treatment outcomes of a randomized trial of unruptured brain arteriovenous malformation-eligible unruptured brain arteriovenous malformation patients. Neurosurgery. 2018;83(3):548\u2013555.29040773"},{"issue":"2","key":"b5","series-title":"N Engl J Med","first-page":"146","article-title":"The risk of hemorrhage after radiosurgery for cerebral arteriovenous malformations","volume":"352","author":"Maruyama K","year":"2005","unstructured":"Maruyama K, Kawahara N, Shin M,  The risk of hemorrhage after radiosurgery for cerebral arteriovenous malformations. N Engl J Med. 2005;352(2):146\u2013153.15647577"},{"issue":"9917","key":"b6","series-title":"Lancet","first-page":"614","article-title":"Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial","volume":"383","author":"Mohr JP","year":"2014","unstructured":"Mohr JP, Parides MK, Stapf C,  Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial. Lancet. 2014;383(9917):614\u2013621."},{"issue":"18","key":"b7","series-title":"JAMA","first-page":"2011","article-title":"Treatment of brain arteriovenous malformations: a systematic review and meta-analysis","volume":"306","author":"van Beijnum J","year":"2011","unstructured":"van Beijnum J, van der Worp HB, Buis DR,  Treatment of brain arteriovenous malformations: a systematic review and meta-analysis. JAMA. 2011;306(18):2011\u20132019.22068993"},{"issue":"7","key":"b8","series-title":"Stroke","first-page":"1703","article-title":"R2eD AVM score","volume":"50","author":"Feghali J","year":"2019","unstructured":"Feghali J, Yang W, Xu R,  R2eD AVM score. Stroke. 2019;50(7):1703\u20131710.31167618"},{"key":"b9","series-title":"Med Hypotheses","first-page":"86","article-title":"Cerebral arteriovenous malformation venous stenosis is associated with hemodynamic changes at the draining vein-venous sinus junction","volume":"123","author":"Alqadi M","year":"2019","unstructured":"Alqadi M, Brunozzi D, Linninger A, Amin-Hanjani S, Charbel FT, Alaraj A. Cerebral arteriovenous malformation venous stenosis is associated with hemodynamic changes at the draining vein-venous sinus junction. Med Hypotheses. 2019;123:86\u201388.30696602"},{"issue":"5","key":"b10","series-title":"J Neurosurg","first-page":"1574","article-title":"Stasis index from hemodynamic analysis using quantitative DSA correlates with hemorrhage of supratentorial arteriovenous malformation: a cross-sectional study","volume":"132","author":"Lin TM","year":"2019","unstructured":"Lin TM, Yang HC, Lee CC,  Stasis index from hemodynamic analysis using quantitative DSA correlates with hemorrhage of supratentorial arteriovenous malformation: a cross-sectional study. J Neurosurg. 2019;132(5):1574\u20131582.31026828"},{"issue":"10","key":"b11","series-title":"Stroke","first-page":"2881","article-title":"Higher flow is present in unruptured arteriovenous malformations with silent intralesional microhemorrhages","volume":"48","author":"Chen X","year":"2017","unstructured":"Chen X, Cooke DL, Saloner D,  Higher flow is present in unruptured arteriovenous malformations with silent intralesional microhemorrhages. Stroke. 2017;48(10):2881\u20132884.28855391"},{"issue":"5","key":"b12","series-title":"Transl Stroke Res","first-page":"871","article-title":"Quantitative angiographic hemodynamic evaluation after revascularization surgery for moyamoya disease","volume":"11","author":"Chen Y","year":"2020","unstructured":"Chen Y, Ma L, Yang S,  Quantitative angiographic hemodynamic evaluation after revascularization surgery for moyamoya disease. Transl Stroke Res. 2020;11(5):871\u2013881.32056157"},{"issue":"6","key":"b13","series-title":"Stroke","first-page":"1430","article-title":"Reporting terminology for brain arteriovenous malformation clinical and radiographic features for use in clinical trials","volume":"32","author":"Atkinson RP","year":"2001","unstructured":"Atkinson RP, Awad IA, Batjer HH,  Reporting terminology for brain arteriovenous malformation clinical and radiographic features for use in clinical trials. Stroke. 2001;32(6):1430\u20131442.11387510"},{"issue":"10","key":"b14","series-title":"AJNR Am J Neuroradiol","first-page":"1883","article-title":"Peritherapeutic hemodynamic changes of carotid stenting evaluated with quantitative DSA in patients with carotid stenosis","volume":"37","author":"Teng MMH","year":"2016","unstructured":"Teng MMH, Chang FC, Lin CJ, Chiang L, Hong JS, Kao YH. Peritherapeutic hemodynamic changes of carotid stenting evaluated with quantitative DSA in patients with carotid stenosis. AJNR Am J Neuroradiol. 2016;37(10):1883\u20131888.27173363"},{"issue":"10","key":"b15","series-title":"Stroke","first-page":"2410","article-title":"Analysis of mean transit time of contrast medium in ruptured and unruptured arteriovenous malformations: a digital subtraction angiographic study","volume":"34","author":"Todaka T","year":"2003","unstructured":"Todaka T, Hamada J, Kai Y, Morioka M, Ushio Y. Analysis of mean transit time of contrast medium in ruptured and unruptured arteriovenous malformations: a digital subtraction angiographic study. Stroke. 2003;34(10):2410\u20132414.12970520"},{"issue":"12","key":"b16","series-title":"AJNR Am J Neuroradiol","first-page":"2303","article-title":"Interrater reliability in the measurement of flow characteristics on color-coded quantitative DSA of brain AVMs","volume":"41","author":"Narsinh KH","year":"2020","unstructured":"Narsinh KH, Mueller K, Nelson J,  Interrater reliability in the measurement of flow characteristics on color-coded quantitative DSA of brain AVMs. AJNR Am J Neuroradiol. 2020;41(12):2303\u20132310.33122213"},{"issue":"11","key":"b17","series-title":"Stroke","first-page":"2910","article-title":"Persistent hemodynamic changes in ruptured brain arteriovenous malformations","volume":"43","author":"Illies T","year":"2012","unstructured":"Illies T, Forkert ND, Saering D,  Persistent hemodynamic changes in ruptured brain arteriovenous malformations. Stroke. 2012;43(11):2910\u20132915.23091120"},{"issue":"4","key":"b18","series-title":"J Neurosurg","first-page":"673","article-title":"A simple relationship between radiological arteriovenous malformation hemodynamics and clinical presentation: a prospective, blinded analysis of 31 cases","volume":"90","author":"Norris JS","year":"1999","unstructured":"Norris JS, Valiante TA, Wallace MC,  A simple relationship between radiological arteriovenous malformation hemodynamics and clinical presentation: a prospective, blinded analysis of 31 cases. J Neurosurg. 1999;90(4):673\u2013679.10193612"},{"issue":"8","key":"b19","series-title":"Stroke","first-page":"2461","article-title":"Hemodynamic quantification in brain arteriovenous malformations with time-resolved spin-labeled magnetic resonance angiography","volume":"45","author":"Raoult H","year":"2014","unstructured":"Raoult H, Bannier E, Maurel P,  Hemodynamic quantification in brain arteriovenous malformations with time-resolved spin-labeled magnetic resonance angiography. Stroke. 2014;45(8):2461\u20132464.24984747"},{"issue":"2","key":"b20","series-title":"J Neurosurg","first-page":"167","article-title":"Occlusive hyperemia: a theory for the hemodynamic complications following resection of intracerebral arteriovenous malformations","volume":"78","author":"al-Rodhan NR","year":"1993","unstructured":"al-Rodhan NR, Sundt TM Jr, Piepgras DG, Nichols DA, R\u00fcfenacht D, Stevens LN. Occlusive hyperemia: a theory for the hemodynamic complications following resection of intracerebral arteriovenous malformations. J Neurosurg. 1993;78(2):167\u2013175.8421198"},{"issue":"6","key":"b21","series-title":"J Neurosurg","first-page":"859","article-title":"Unruptured intracranial aneurysms and arteriovenous malformations: frequency of intracranial hemorrhage and relationship of lesions","volume":"73","author":"Brown RD Jr","year":"1990","unstructured":"Brown RD Jr, Wiebers DO, Forbes GS. Unruptured intracranial aneurysms and arteriovenous malformations: frequency of intracranial hemorrhage and relationship of lesions. J Neurosurg. 1990;73(6):859\u2013863.2230969"},{"issue":"4","key":"b22","series-title":"J Magn Reson Imaging","first-page":"946","article-title":"Cerebral arteriovenous malformation: complex 3D hemodynamics and 3D blood flow alterations during staged embolization","volume":"38","author":"Markl M","year":"2013","unstructured":"Markl M, Wu C, Hurley MC,  Cerebral arteriovenous malformation: complex 3D hemodynamics and 3D blood flow alterations during staged embolization. J Magn Reson Imaging. 2013;38(4):946\u2013950.24027116"},{"issue":"2","key":"b23","series-title":"Stroke","first-page":"504","article-title":"Draining vein pressure increases and hemorrhage in patients with arteriovenous malformation","volume":"25","author":"Miyasaka Y","year":"1994","unstructured":"Miyasaka Y, Kurata A, Tokiwa K, Tanaka R, Yada K, Ohwada T. Draining vein pressure increases and hemorrhage in patients with arteriovenous malformation. Stroke. 1994;25(2):504\u2013507.8303764"},{"issue":"6","key":"b24","series-title":"J Neurosurg","first-page":"918","article-title":"Relationship of perfusion pressure and size to risk of hemorrhage from arteriovenous malformations","volume":"76","author":"Spetzler RF","year":"1992","unstructured":"Spetzler RF, Hargraves RW, McCormick PW, Zabramski JM, Flom RA, Zimmerman RS. Relationship of perfusion pressure and size to risk of hemorrhage from arteriovenous malformations. J Neurosurg. 1992;76(6):918\u2013923.1588424"},{"issue":"2","key":"b25","series-title":"Circ Res","first-page":"165","article-title":"Acute vascular endothelial changes associated with increased blood velocity gradients","volume":"22","author":"Fry DL","year":"1968","unstructured":"Fry DL. Acute vascular endothelial changes associated with increased blood velocity gradients. Circ Res. 1968;22(2):165\u2013197.5639037"},{"issue":"5","key":"b26","series-title":"Neurosurg Focus","first-page":"E11","article-title":"Cerebral arteriovenous malformations. Part 2: physiology","volume":"26","author":"Moftakhar P","year":"2009","unstructured":"Moftakhar P, Hauptman JS, Malkasian D, Martin NA. Cerebral arteriovenous malformations. Part 2: physiology. Neurosurg Focus. 2009;26(5):E11.19408989"},{"key":"b27","series-title":"Front Physiol","first-page":"1250","article-title":"Computational network modeling of intranidal hemodynamic compartmentalization in a theoretical three-dimensional brain arteriovenous malformation","volume":"10","author":"Jain MS","year":"2019","unstructured":"Jain MS, Do HM, Massoud TF. Computational network modeling of intranidal hemodynamic compartmentalization in a theoretical three-dimensional brain arteriovenous malformation. Front Physiol. 2019;10:1250."},{"key":"b28","series-title":"World Neurosurg","first-page":"e873","article-title":"In vitro modeling of human brain arteriovenous malformation for endovascular simulation and flow analysis","volume":"141","author":"Kaneko N","year":"2020","unstructured":"Kaneko N, Ullman H, Ali F,  In vitro modeling of human brain arteriovenous malformation for endovascular simulation and flow analysis. World Neurosurg. 2020;141:e873\u2013e879.32565379"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/138\/3\/article-p740.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/138\/3\/article-p740.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/138\/3\/article-p740.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T08:13:05Z","timestamp":1732176785000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/138\/3\/article-p740.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":28,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/2022.6.jns212818","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,1]]}}}