{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:55:26Z","timestamp":1794048926192,"version":"4.8.0"},"reference-count":33,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Meningioma prognostication and treatment continues to evolve with an increasing understanding of tumor biology. In this study, the authors aimed to test conventional predictors of meningioma recurrence, histopathology variables for which there exists some controversy (brain invasion), as well as a novel molecular-based location paradigm.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>This is a retrospective study of a consecutive series of patients with WHO grade I\u2013III meningioma resected at The University of Texas Southwestern Medical Center between 1994 and 2015. Time to meningioma recurrence (i.e., recurrence-free survival [RFS]) was the primary endpoint measured. Kaplan-Meier curves were constructed and compared using log-rank tests. Cox univariate and multivariate analyses were performed to identify predictors of RFS.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>A total of 703 consecutive patients with meningioma underwent resection at The University of Texas Southwestern Medical Center between the years 1994 and 2015. A total of 158 patients were excluded for insufficient follow-up (&lt; 3 months). The median age of the cohort was 55 years (range 16\u201388 years) and 69.5% (n = 379) were female. The median follow-up was 48 months (range 3\u2013289 months). There was not a significantly increased risk of recurrence in patients with evidence of brain invasion, in patients with otherwise WHO grade I meningioma (Cox univariate HR 0.92, 95% CI 0.44\u20131.91, p = 0.82, power 4.4%). Adjuvant radiosurgery to subtotally resected WHO grade I meningiomas did not prolong the time to recurrence (n = 52, Cox univariate HR 0.21, 95% CI 0.03\u20131.61, p = 0.13, power 71.6%). Location (midline skull base, lateral skull base, and paravenous) was significantly associated with RFS (p &lt; 0.01, log-rank test). In patients with high-grade meningiomas (WHO grade II or III), location was predictive of RFS (p = 0.03, log-rank test), with paravenous meningiomas exhibiting the highest rates of recurrence. Location was not significant on multivariate analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>The data suggest that brain invasion does not increase the risk of recurrence in otherwise WHO grade I meningioma. Adjuvant radiosurgery to subtotally resected WHO grade I meningiomas did not prolong the time to recurrence. Location categorized by distinct molecular signatures did not predict RFS in a multivariate model. Larger studies are needed to confirm these findings.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2022.6.jns221162","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T19:50:35Z","timestamp":1661370635000},"page":"621-628","source":"Crossref","is-referenced-by-count":18,"title":["Evaluating risk of recurrence in patients with meningioma"],"prefix":"10.3171","volume":"138","author":[{"given":"Jeffrey I.","family":"Traylor","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron R.","family":"Plitt","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabarak M.","family":"Mian","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce E.","family":"Mickey","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel L.","family":"Barnett","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"12)(suppl 2","key":"b1","series-title":"Neuro Oncol","first-page":"iv1","article-title":"CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013-2017","volume":"22","author":"Ostrom QT","year":"2020","unstructured":"Ostrom QT, Patil N, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013-2017. Neuro Oncol. 2020;22(12)(suppl 2):iv1\u2013iv96.33123732"},{"issue":"8","key":"b2","series-title":"Neuro Oncol","first-page":"1231","article-title":"The 2021 WHO Classification of Tumors of the Central Nervous System: a summary","volume":"23","author":"Louis DN","year":"2021","unstructured":"Louis DN, Perry A, Wesseling P,  The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021;23(8):1231\u20131251.34185076"},{"issue":"1","key":"b3","series-title":"A RANO review. J Neurosurg","first-page":"4","article-title":"Meningiomas: knowledge base, treatment outcomes, and uncertainties","volume":"122","author":"Rogers L","year":"2015","unstructured":"Rogers L, Barani I, Chamberlain M,  Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review. 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