{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:33:28Z","timestamp":1789086808228,"version":"build-2803163510"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Trigeminal neuralgia (TN) secondary to tumor represents a rare and diverse entity, and treatment for secondary TN remains controversial. This report reviews a single institution\u2019s experience in treating secondary TN with stereotactic radiosurgery (SRS) and focuses on the durability of pain relief with respect to various treatment targets, i.e., the trigeminal nerve, offending tumor, or both.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Between the years 2009 and 2021, 21 patients with TN secondary to benign (n = 13) or malignant (n = 8) tumors underwent SRS. Barrow Neurological Institute (BNI) pain intensity scale scores were collected from patient electronic medical records at baseline, initial follow-up, and 1 and 3 years post-SRS. The interval change in BNI scale score (\u0394BNI) at the various follow-up time points was also calculated to assess the durability of pain relief following SRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The median follow-up period was 24 (range 0.5\u2013155) months. Five patients (24%) received treatment to the trigeminal nerve only, 10 (48%) received treatment to the tumor only, and 6 (29%) had treatment to both the nerve and tumor. The overall radiation dosage ranged from 14 to 60 Gy delivered in 1\u20135 fractions, with a median overall dose of 26 Gy. The median dose to the tumor was 22.5 (range 14\u201335) Gy, delivered in 1\u20135 fractions. Of the treatments targeting the tumor, 25% were delivered in a single fraction with doses ranging from 14 to 20 Gy, 60% were delivered in 3 fractions with doses ranging from 18 to 27 Gy, and 15% were delivered in 5 fractions with doses ranging from 25 to 35 Gy. The most common dose regimen for tumor treatment was 24 Gy in 3 fractions. The median biologically effective dose (with an assumed alpha\/beta ratio of 10 [BED\n                      <jats:sub>10<\/jats:sub>\n                      ]) for tumor treatments was 43.1 (range 13.3\u201360.0) Gy. There was a significant difference in the proportion of patients with recurrent pain (\u0394BNI score \u2265 0) at the time of last follow-up across the differing SRS treatment targets: trigeminal nerve only, tumor only, or both (p = 0.04). At the time of last follow-up, the median \u0394BNI score after SRS to the nerve only was \u22121, 0 after SRS to tumor only, and \u22122 after SRS to both targets.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>SRS offers clinical symptomatic benefit to patients with TN secondary to tumor. For optimal pain relief and response durability, treatment targeting both the tumor and the trigeminal nerve appears to be most advantageous.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2022.8.focus22381","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T07:20:21Z","timestamp":1667287221000},"page":"E3","source":"Crossref","is-referenced-by-count":13,"title":["Stereotactic radiosurgery for trigeminal neuralgia secondary to tumor: a single-institution retrospective series"],"prefix":"10.3171","volume":"53","author":[{"given":"Jennifer C.","family":"Hall","sequence":"first","affiliation":[{"name":"Departments of Radiation Oncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy H.","family":"Ung","sequence":"additional","affiliation":[{"name":"Neurosurgery, Stanford University, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamra-Lee","family":"McCleary","sequence":"additional","affiliation":[{"name":"Neurosurgery, Stanford University, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Chuang","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris C.","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott G.","family":"Soltys","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Hayden Gephart","sequence":"additional","affiliation":[{"name":"Neurosurgery, Stanford University, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Li","sequence":"additional","affiliation":[{"name":"Neurosurgery, Stanford University, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erqi L.","family":"Pollom","sequence":"additional","affiliation":[{"name":"Departments of Radiation Oncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Chang","sequence":"additional","affiliation":[{"name":"Neurosurgery, Stanford University, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Meola","sequence":"additional","affiliation":[{"name":"Neurosurgery, Stanford University, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"7","key":"b1","series-title":"Cephalalgia","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1177\/0333102416687280","article-title":"Trigeminal neuralgia\u2014diagnosis and treatment","volume":"37","author":"Maarbjerg S","year":"2017","unstructured":"Maarbjerg S, Di Stefano G, Bendtsen L, Cruccu G. 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