{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:16:24Z","timestamp":1793412984911,"version":"4.5.0"},"reference-count":78,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Idiopathic normal pressure hydrocephalus (iNPH) represents an insidious type of dementia considered reversible after shunt placement. Although the clinical outcome has been widely studied, few studies have reported on quality of life (QOL) after surgery. This study evaluated the long-term clinical and QOL outcomes of iNPH patients after ventriculoperitoneal shunt (VPS) implantation. Factors influencing QOL in iNPH were also investigated.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n From 2009 to 2020, a single-institution retrospective study was conducted to compare shunted iNPH patients with a homogeneous control group. QOL was analyzed using the SF-36 questionnaire with yearly follow-up for as long as 11 years. Severity of symptoms, comorbidities, and clinical data were also recorded.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Among 187 treated patients, 15 had died at the time of the authors\u2019 evaluation, and 45 did not match the inclusion criteria. The mean \u00b1 SD (range) follow-up was 118.5 \u00b1 4.2 (18\u2013132) months. QOL improved in 103\/130 (79%) patients through 5 years after shunt surgery, although it remained lower than that of the control group (p < 0.0001). The SF-36 score reduced progressively, reaching baseline at 5\u20137 years of follow-up and decreased to below baseline at 7\u201311 years of follow-up (p < 0.0001). Predictors of improved QOL were younger age (p < 0.001), lower body mass index (BMI) (p < 0.001), and better Mini-Mental State Examination (MMSE) performance (p < 0.001) before surgery. Decreased postoperative QOL was associated with cerebrovascular disease, diabetes, and severity of symptoms (gait and cognition) at presentation (p < 0.001).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n VPS implantation, along with a strict and comprehensive follow-up, has been shown to improve QOL in iNPH patients for as long as 5 years after surgery. Younger age, lower BMI, and better MMSE score are positive predictors of improved QOL after shunt placement.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2023.1.focus22643","type":"journal-article","created":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T08:25:57Z","timestamp":1680337557000},"page":"E7","source":"Crossref","is-referenced-by-count":20,"title":["The impact of cerebrospinal fluid shunting on quality of life in idiopathic normal pressure hydrocephalus: a long-term analysis"],"prefix":"10.3171","volume":"54","author":[{"given":"Giovanni","family":"Grasso","sequence":"first","affiliation":[{"name":"Neurosurgical Unit, Department of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Torregrossa","sequence":"additional","affiliation":[{"name":"Neurosurgical Unit, Department of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"3","key":"b1","series-title":"Neuroepidemiology","first-page":"171","article-title":"Prevalence of possible idiopathic normal-pressure hydrocephalus in Japan: the Osaki-Tajiri project","volume":"32","author":"Tanaka N","year":"2009","unstructured":"Tanaka N, Yamaguchi S, Ishikawa H, Ishii H, Meguro K. 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