{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:30:54Z","timestamp":1783081854985,"version":"3.54.6"},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Unruptured, wide-necked middle cerebral artery (WN-MCA) aneurysms have traditionally been considered ideal candidates for microsurgery (MS), although endovascular treatment (EVT) has dramatically increased in popularity with the advent of novel devices such as intrasaccular flow disruptors. The purpose of this study was to evaluate the safety and efficacy of MS versus EVT for unruptured WN-MCA aneurysms.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>The NeuroVascular Quality Initiative Quality Outcomes Database (NVQI-QOD) Cerebral Aneurysm Registry, a multiinstitutional, prospectively collected procedural database, was queried for cases of unruptured WN-MCA aneurysms treated with MS or EVT between 2015 and 2022. A wide neck was defined as an aneurysm neck \u2265 4 mm or a dome\/neck ratio \u2264 2. Demographics and aneurysm characteristics were queried. Propensity score matching (PSM) was utilized to match aneurysm size, number of aneurysms treated, patient age, and aneurysm status. Safety outcomes were evaluated including intraoperative and postoperative complication rates. Aneurysm occlusion status and clinical outcomes using the modified Rankin Scale (mRS) score at discharge and the last follow-up were also assessed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Of 671 unruptured MCA aneurysms, 319 were wide necked. Thirty cases were excluded, as the aneurysm had been previously treated. Two hundred eighty-nine operations (203 EVT, 86 MS) in 282 patients satisfied inclusion criteria. After PSM, there were 86 operations in each group for analysis. The mean aneurysm width was 5.0 (EVT) versus 4.9 mm (MS; p = 0.285). Safety data showed similar intraoperative (7.0% EVT vs 3.5% MS, p = 0.496) and postoperative (4.7% vs 7%, p = 0.746) complication rates. The MS patients were more likely to have complete aneurysm occlusion at discharge (90.4% vs 58.8%, p &lt; 0.001). In a limited subset of patients (52.9%) for whom outcome data were available, the EVT patients were more likely to have an mRS score 0 at discharge (50\/59 [84.7%] vs 29\/54 [53.7%], p &lt; 0.0003] and at the last follow-up (36\/55 [65.5%] vs 13\/36 [36.1%], p = 0.006).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>This study describes a large, modern cohort of propensity score\u2013matched patients who underwent treatment of unruptured WN-MCA aneurysms. Safety data on intraoperative and postoperative complication rates were similar in both treatment groups. MS was more likely to result in complete aneurysm occlusion at discharge. In a subset of patients with available outcome data, EVT was associated with better functional outcomes at discharge and the last follow-up. Given the lack of complete follow-up data and rates of retreatment, these results should be interpreted cautiously.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.10.jns231659","type":"journal-article","created":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T01:20:58Z","timestamp":1703899258000},"page":"1736-1744","source":"Crossref","is-referenced-by-count":5,"title":["Safety and efficacy of endovascular versus microsurgical treatment of unruptured wide-necked middle cerebral artery aneurysms: a propensity score\u2013matched analysis of the NeuroVascular Quality Initiative Quality Outcomes Database Cerebral Aneurysm Registry"],"prefix":"10.3171","volume":"140","author":[{"given":"Varun","family":"Padmanaban","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Public Health Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Public Health Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer A.","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay U.","family":"Howington","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neurosurgical & Spine Institute of Savannah, Savannah, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Sahlein","sequence":"additional","affiliation":[{"name":"Neuro-interventional Radiology, Goodman Campbell Brain and Spine, Indianapolis, Indiana; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan G.","family":"Tejada","sequence":"additional","affiliation":[{"name":"Department of Radiology, Indiana University, Indianapolis, Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Andrew","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Simon","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M.","family":"Cockroft","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"Public Health Sciences,"},{"name":"Radiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ephraim W.","family":"Church","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"Radiology, and"},{"name":"Neurology, Penn State Health, Hershey, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"4","key":"b1","series-title":"Neurosurgery","first-page":"780","article-title":"Surgical management of middle cerebral artery aneurysms","volume":"48","author":"Heros RC","year":"2001","unstructured":"Heros RC, Fritsch MJ. 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