{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:02:50Z","timestamp":1787025770978,"version":"build-2736575974"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The authors sought to determine the time to recurrence after achieving gross-total resection of nonfunctioning pituitary adenoma (NFPA) in adult patients. The authors also sought to determine the rate of recurrence after increasing years of recurrence-free imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors performed a retrospective chart review of all adult patients who underwent gross-total resection of NFPA between September 2004 and January 2018 by the senior surgeon. The primary outcome of the study was time to recurrence, defined by imaging and\/or clinical criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The median follow-up time of the 148 patients who met the inclusion criteria was 91 months; 12 of these patients (8.1%) had recurrence. The median time to recurrence was 80 months. The range of time for these recurrences was 36\u2013156 months. The probabilities of remaining recurrence free at 180 months after gross-total resection of NFPA and 12, 36, 60, 84, or 120 months of recurrence-free imaging were 82%, 84%, 86%, 88%, and 93%, respectively. The year-over-year odds of a recurrence increased linearly by 1.07%. There was no difference in recurrence-free imaging when patients were stratified by Knosp grade or tumor subtype. None of the patients with recurrence underwent repeat resection. When identified, patients were managed either conservatively or with radiosurgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Increased intervals of recurrence-free imaging were not associated with a decrease in risk of recurrence, which suggests that patients require life-long periodic imaging. If followed with periodic imaging, recurrence can be discovered before clinically symptomatic and successfully treated without repeat surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2023.10.jns23754","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T20:22:54Z","timestamp":1702066974000},"page":"1614-1619","source":"Crossref","is-referenced-by-count":4,"title":["Conditioned recurrence-free survival following gross-total resection of nonfunctioning pituitary adenoma: a single-surgeon, single-center retrospective study"],"prefix":"10.3171","volume":"140","author":[{"given":"Jesse J.","family":"McClure","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Chatrath","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trae R.","family":"Robison","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Jane","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"suppl","key":"b1","series-title":"Neurol India","first-page":"S92","article-title":"The importance of long term follow up after endoscopic pituitary surgery: durability of results and tumor recurrence","volume":"68","author":"Almeida JP","year":"2020","unstructured":"Almeida JP, Tabasinejad R, Kalyvas A,  The importance of long term follow up after endoscopic pituitary surgery: durability of results and tumor recurrence. Neurol India. 2020;68(suppl):S92-S100."},{"key":"b2","series-title":"World Neurosurg","first-page":"e341","article-title":"Endoscopic endonasal pituitary surgery for nonfunctioning pituitary adenomas: long-term outcomes and management of recurrent tumors","volume":"146","author":"Bernat AL","year":"2021","unstructured":"Bernat AL, Troude P, Priola SM,  Endoscopic endonasal pituitary surgery for nonfunctioning pituitary adenomas: long-term outcomes and management of recurrent tumors. World Neurosurg. 2021;146:e341\u2013e350."},{"issue":"4","key":"b3","series-title":"J Neurosurg","first-page":"736","article-title":"Long-term recurrence and mortality after surgery and adjuvant radiotherapy for nonfunctional pituitary adenomas","volume":"108","author":"Chang EF","year":"2008","unstructured":"Chang EF, Zada G, Kim S,  Long-term recurrence and mortality after surgery and adjuvant radiotherapy for nonfunctional pituitary adenomas. J Neurosurg. 2008;108(4):736-745."},{"issue":"2","key":"b4","series-title":"J Neurosurg","first-page":"535","article-title":"Long-term outcomes after endoscopic endonasal surgery for nonfunctioning pituitary macroadenomas","volume":"134","author":"Gerges MM","year":"2020","unstructured":"Gerges MM, Rumalla K, Godil SS,  Long-term outcomes after endoscopic endonasal surgery for nonfunctioning pituitary macroadenomas. J Neurosurg. 2020;134(2):535-546."},{"issue":"2","key":"b5","series-title":"Gland Surg","first-page":"807","article-title":"Nomogram predictive model of post-operative recurrence in non-functioning pituitary adenoma","volume":"10","author":"Lyu W","year":"2021","unstructured":"Lyu W, Fei X, Chen C, Tang Y. Nomogram predictive model of post-operative recurrence in non-functioning pituitary adenoma. Gland Surg. 2021;10(2):807-815."},{"issue":"2","key":"b6","series-title":"Oper Neurosurg (Hagerstown)","first-page":"127","article-title":"surgical outcomes following repeat transsphenoidal surgery for nonfunctional pituitary adenomas: a retrospective comparative study","volume":"16","author":"Bakhsheshian J","year":"2019","unstructured":"Bakhsheshian J, Wheeler S, Strickland BA,  surgical outcomes following repeat transsphenoidal surgery for nonfunctional pituitary adenomas: a retrospective comparative study. Oper Neurosurg (Hagerstown). 2019;16(2):127-135."},{"key":"b7","series-title":"Front Endocrinol (Lausanne)","article-title":"Analysis of related factors of tumor recurrence or progression after transnasal sphenoidal surgical treatment of large and giant pituitary adenomas and establish a nomogram to predict tumor prognosis","volume":"12","author":"Chen Y","year":"2021","unstructured":"Chen Y, Cai F, Cao J,  Analysis of related factors of tumor recurrence or progression after transnasal sphenoidal surgical treatment of large and giant pituitary adenomas and establish a nomogram to predict tumor prognosis. Front Endocrinol (Lausanne). 2021;12:793337."},{"issue":"1","key":"b8","series-title":"Neurosurgery","first-page":"42","article-title":"Long-term results of endonasal endoscopic transsphenoidal resection of nonfunctioning pituitary macroadenomas","volume":"76","author":"Dallapiazza RF","year":"2015","unstructured":"Dallapiazza RF, Grober Y, Starke RM, Laws ER Jr, Jane JA Jr. Long-term results of endonasal endoscopic transsphenoidal resection of nonfunctioning pituitary macroadenomas. Neurosurgery. 2015;76(1):42-53."},{"key":"b9","article-title":"WHO Classification of Tumours Editorial Board. Central Nervous System Tumours","year":"2022","unstructured":"WHO Classification of Tumours Editorial Board. Central Nervous System Tumours. 5th ed. World Health Organization; 2022."},{"key":"b10","series-title":"Acta Neurochir Suppl (Wien)","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-3-7091-9183-5_12","article-title":"Pituitary adenomas with parasellar invasion","volume":"53","author":"Knosp E","year":"1991","unstructured":"Knosp E, Kitz K, Steiner E, Matula C. Pituitary adenomas with parasellar invasion. Acta Neurochir Suppl (Wien). 1991;53:65-71."},{"issue":"3","key":"b11","series-title":"Clin Endocrinol (Oxf)","first-page":"354","article-title":"Long-term follow-up of a large prospective cohort of patients with nonfunctioning pituitary adenomas: the outcome of a conservative management policy","volume":"89","author":"Levy MJ","year":"2018","unstructured":"Levy MJ, Robertson IJ, Khalk N,  Long-term follow-up of a large prospective cohort of patients with nonfunctioning pituitary adenomas: the outcome of a conservative management policy. 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Rhinology. 2015;53(4):308-316."},{"issue":"5","key":"b14","series-title":"Eur J Endocrinol","first-page":"739","article-title":"Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma?","volume":"165","author":"Reddy R","year":"2011","unstructured":"Reddy R, Cudlip S, Byrne JV, Karavitaki N, Wass JA. Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma? Eur J Endocrinol. 2011;165(5):739-744."},{"issue":"2","key":"b15","series-title":"Endocrine","first-page":"407","article-title":"Non-functioning pituitary macroadenomas: factors affecting postoperative recurrence, and pre- and post-surgical endocrine and visual function","volume":"73","author":"Subramanian V","year":"2021","unstructured":"Subramanian V, Lee RSM, Howell S,  Non-functioning pituitary macroadenomas: factors affecting postoperative recurrence, and pre- and post-surgical endocrine and visual function. Endocrine. 2021;73(2):407-415."},{"issue":"2","key":"b16","series-title":"Neurosurg Rev","first-page":"1401","article-title":"Solid tumor size for prediction of recurrence in large and giant non-functioning pituitary adenomas","volume":"45","author":"Ko CC","year":"2022","unstructured":"Ko CC, Chang CH, Chen TY,  Solid tumor size for prediction of recurrence in large and giant non-functioning pituitary adenomas. Neurosurg Rev. 2022;45(2):1401-1411."},{"key":"b17","series-title":"Front Endocrinol (Lausanne)","first-page":"748997","article-title":"Prediction of the recurrence of non-functioning pituitary adenomas using preoperative supra-intra sellar volume and tumor-carotid distance","volume":"12","author":"Chen W","year":"2021","unstructured":"Chen W, Wang M, Duan C,  Prediction of the recurrence of non-functioning pituitary adenomas using preoperative supra-intra sellar volume and tumor-carotid distance. Front Endocrinol (Lausanne). 2021;12:748997."},{"issue":"5","key":"b18","series-title":"Pituitary","first-page":"520","article-title":"Predictive modeling for pituitary adenomas: single center experience in 501 consecutive patients","volume":"22","author":"Pappy AL II","year":"2019","unstructured":"Pappy AL II, Savinkina A, Bicknese C, Neill S, Oyesiku NM, Ioachimescu AG. Predictive modeling for pituitary adenomas: single center experience in 501 consecutive patients. Pituitary. 2019;22(5):520-531."},{"key":"b19","series-title":"Front Oncol","first-page":"882049","article-title":"Development and validation of a prognostic model for post-operative recurrence of pituitary adenomas","volume":"12","author":"Lu L","year":"2022","unstructured":"Lu L, Wan X, Xu Y, Chen J, Shu K, Lei T. Development and validation of a prognostic model for post-operative recurrence of pituitary adenomas. Front Oncol. 2022;12:882049."},{"issue":"2","key":"b20","series-title":"J Neurooncol","first-page":"491","article-title":"Prognostic implication of size on outcomes of pituitary macroadenoma: a comparative analysis of giant adenoma with non-giant macroadenoma","volume":"160","author":"Raghib MF","year":"2022","unstructured":"Raghib MF, Salim A, Angez M,  Prognostic implication of size on outcomes of pituitary macroadenoma: a comparative analysis of giant adenoma with non-giant macroadenoma. J Neurooncol. 2022;160(2):491-496."},{"key":"b21","series-title":"J Clin Neurosci","first-page":"49","article-title":"Invasive pituitary adenomas with gross total resection: the wait-and-see policy during postoperative management","volume":"58","author":"Lv L","year":"2018","unstructured":"Lv L, Zhang B, Wang M,  Invasive pituitary adenomas with gross total resection: the wait-and-see policy during postoperative management. J Clin Neurosci. 2018;58:49\u201355."},{"issue":"2","key":"b22","series-title":"Hormones (Athens)","first-page":"254","article-title":"Factors influencing the outcome of microsurgical transsphenoidal surgery for pituitary adenomas: a study on 184 patients","volume":"12","author":"Lampropoulos KI","year":"2013","unstructured":"Lampropoulos KI, Samonis G, Nomikos P. Factors influencing the outcome of microsurgical transsphenoidal surgery for pituitary adenomas: a study on 184 patients. Hormones (Athens). 2013;12(2):254-264."},{"issue":"9","key":"b23","series-title":"J Clin Med","first-page":"2464","article-title":"Classifying pituitary adenoma invasiveness based on radiological, surgical and histological features: a retrospective assessment of 903 cases","volume":"11","author":"Lu L","year":"2022","unstructured":"Lu L, Wan X, Xu Y, Chen J, Shu K, Lei T. Classifying pituitary adenoma invasiveness based on radiological, surgical and histological features: a retrospective assessment of 903 cases. J Clin Med. 2022;11(9):2464."},{"issue":"5","key":"b24","series-title":"Pituitary","first-page":"467","article-title":"Predicting early post-operative remission in pituitary adenomas: evaluation of the modified Knosp classification","volume":"22","author":"Buchy M","year":"2019","unstructured":"Buchy M, Lapras V, Rabilloud M,  Predicting early post-operative remission in pituitary adenomas: evaluation of the modified Knosp classification. 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