{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:29:38Z","timestamp":1789007378677,"version":"build-2803163510"},"reference-count":52,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The 2021 WHO classification of CNS tumors has refined the definition of adult-type diffuse gliomas without 1p19q codeletion. Nevertheless, the aggressiveness of gliomas is based exclusively on histomolecular criteria performed on a limited sample of the tumor. The authors aimed to assess whether the spontaneous radiographic tumor growth rate is associated with tumor aggressiveness and allows preoperative identification of malignancy grade of adult-type diffuse gliomas without 1p19q codeletion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors retrospectively reviewed the records of adult patients harboring a newly diagnosed supratentorial diffuse glioma without 1p19q codeletion, with available preoperative MRI follow-up between January 2008 and April 2022. The spontaneous radiographic tumor growth rate was quantified by tumor volume segmentation and regression of the evolution of the mean tumor diameter over time and was compared with clinical, imaging, histomolecular, and survival data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Ninety-six patients were included. The spontaneous radiographic tumor growth rates (mean 17.8 \u00b1 38.8 mm\/year, range 0\u2013243.5 mm\/year) significantly varied according to\n                      <jats:italic>IDH1\/2<\/jats:italic>\n                      mutation (p &lt; 0.001), grade of malignancy (p &lt; 0.001), and presence of microvascular proliferation (p &lt; 0.001). The spontaneous radiographic tumor growth rate allowed preoperative identification of high-grade cases: 100% of grade 3 and 4\n                      <jats:italic>IDH<\/jats:italic>\n                      -mutant diffuse astrocytomas had a spontaneous radiographic tumor growth rate \u2265 8.0 mm\/year, and 100% of\n                      <jats:italic>IDH<\/jats:italic>\n                      \u2013wild-type glioblastomas had a spontaneous radiographic tumor growth rate \u2265 42.0 mm\/year. A spontaneous radiographic growth rate \u2265 8.0 mm\/year was an independent predictor of shorter progression-free (p = 0.014) and overall (p = 0.007) survival. A mitotic count threshold \u2265 4 mitoses was the optimal threshold for identifying aggressive\n                      <jats:italic>IDH<\/jats:italic>\n                      -mutant astrocytomas based on spontaneous radiographic tumor growth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The spontaneous radiographic tumor growth rates could be used as an additional tool to preoperatively screen tumor aggressiveness of adult-type diffuse gliomas without 1p19q codeletion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2023.11.focus23648","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T07:35:40Z","timestamp":1706772940000},"page":"E4","source":"Crossref","is-referenced-by-count":14,"title":["Radiographic growth rate as a predictor of aggressiveness of diffuse gliomas without 1p19q codeletion"],"prefix":"10.3171","volume":"56","author":[{"given":"Arthur","family":"Leclerc","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Caen University Hospital, Caen;"},{"name":"Normandy University, Unicaen ISTCT\/CERVOxy Group UMR6030 GIP CYCERON, Caen;"},{"name":"Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris;"},{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Roux","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris;"},{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Elia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris;"},{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California, Los Angeles, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oumaima","family":"Aboubakr","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris;"},{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Bedioui","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris;"},{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Planet","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris;"},{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Benzakoun","sequence":"additional","affiliation":[{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"},{"name":"Department of Neuroradiology, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia Antonia","family":"Simboli","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris;"},{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnault","family":"Tauziede-Espariat","sequence":"additional","affiliation":[{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"},{"name":"Department of Neuropathology, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Moiraghi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris;"},{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Varlet","sequence":"additional","affiliation":[{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"},{"name":"Department of Neuropathology, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Chr\u00e9tien","sequence":"additional","affiliation":[{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"},{"name":"Department of Neuropathology, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Oppenheim","sequence":"additional","affiliation":[{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"},{"name":"Department of Neuroradiology, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Zanello","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris;"},{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Pallud","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences Sainte-Anne, Paris;"},{"name":"University Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP) INSERM U1266 IMA-BRAIN, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"21","key":"b1","series-title":"J Clin Oncol","first-page":"2394","article-title":"Diffuse infiltrating oligodendroglioma and astrocytoma","volume":"35","author":"van den Bent MJ","year":"2017","unstructured":"van den Bent MJ, Smits M, Kros JM, Chang SM. 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