{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T01:37:25Z","timestamp":1776476245612,"version":"3.51.2"},"reference-count":36,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Cerebral cavernous malformations (CCMs) are the second most common vascular anomaly affecting the CNS in children. Although stereotactic radiosurgery (SRS) has been proposed as an alternative to microsurgery in the management of selected cases in adults, there is a paucity of studies focusing on pediatric patients. The aim of this study was to present the outcomes and associated risks of SRS in this subgroup of patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>This retrospective multicenter study included pediatric patients treated with single-session SRS for CCMs. The annual hemorrhage rate (AHR) was calculated before and after SRS in hemorrhagic lesions. The Engel classification was used to describe post-SRS epileptic control. Adverse radiation effects (AREs) and the occurrence of new neurological deficits were recorded.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The study included 50 patients (median age 15.1 [IQR 5.6] years) harboring 62 CCMs. Forty-two (84%) and 22 (44%) patients had a history of hemorrhage or epilepsy prior to SRS, respectively. The AHR from diagnosis to SRS excluding the first hemorrhage was 7.19 per 100 CCM-years, dropping to 3.15 per 100 CCM-years after treatment. The cumulative risk of first hemorrhage after SRS was 7.4% (95% CI 0%\u201314.3%) at 5 years and 23.6% (95% CI 0%\u201342.2%) at 10 years. Eight hemorrhagic events involving 6 CCMs in 6 patients were recorded in the post-SRS follow-up period; 4 patients presented with transient symptoms and 4 with permanent symptoms. Of the 22 patients with pre-SRS seizures, 11 were seizure free at the last follow-up (Engel class I), 6 experienced improvement (Engel class II or III), 5 had no improvement (Engel class IVA or IVB), and 1 experienced worsening (Engel class IVC). Radiographic AREs were documented in 14.5% (9\/62) of CCMs, with 4 being symptomatic.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Single-session SRS reduces the CCM hemorrhage rate in the pediatric population and provides adequate seizure control.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.11.peds23402","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T04:26:30Z","timestamp":1704515190000},"page":"315-322","source":"Crossref","is-referenced-by-count":6,"title":["Pediatric cerebral cavernous malformations and stereotactic radiosurgery: an analysis of 50 cases from a multicentric study"],"prefix":"10.3171","volume":"33","author":[{"given":"Georgios","family":"Mantziaris","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chloe","family":"Dumot","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia;"},{"name":"Department of Neurological Surgery, Hospices Civils de Lyon, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stylianos","family":"Pikis","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selcuk","family":"Peker","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ko\u00e7 University School of Medicine, Istanbul, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yavuz","family":"Samanci","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ko\u00e7 University School of Medicine, Istanbul, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokce D.","family":"Ardor","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ko\u00e7 University School of Medicine, Istanbul, Turkey;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Nabeel","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt;"},{"name":"Neurosurgery Department, Faculty of Medicine, Benha University, Qalubya, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael A.","family":"Reda","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt;"},{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh R.","family":"Tawadros","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt;"},{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Abdel Karim","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo, Egypt;"},{"name":"Clinical Oncology, Ain Shams University, Cairo, Egypt;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr M. 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