{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:42:29Z","timestamp":1789220549720,"version":"build-2803163510"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Treatment for Chiari malformation type I (CM-I) often includes surgical intervention in both pediatric and adult patients. The authors sought to investigate fundamental differences between these populations by analyzing data from pediatric and adult patients who required CM-I decompression.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>To better understand the presentation and surgical outcomes of both groups of patients, retrospective data from 170 adults and 153 pediatric patients (2000\u20132019) at six institutions were analyzed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The adult CM-I patient population requiring surgical intervention had a greater proportion of female patients than the pediatric population (p &lt; 0.0001). Radiographic findings at initial clinical presentation showed a significantly greater incidence of syringomyelia (p &lt; 0.0001) and scoliosis (p &lt; 0.0001) in pediatric patients compared with adult patients with CM-I. However, presenting signs and symptoms such as headaches (p &lt; 0.0001), ocular findings (p = 0.0147), and bulbar symptoms (p = 0.0057) were more common in the adult group. After suboccipital decompression procedures, 94.4% of pediatric patients reported symptomatic relief compared with 75% of adults with CM-I (p &lt; 0.0001).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Here, the authors present the first retrospective evaluation comparing adult and pediatric patients who underwent CM-I decompression. Their analysis reveals that pediatric and adult patients significantly differ in terms of demographics, radiographic findings, presentation of symptoms, surgical indications, and outcomes. These findings may indicate different clinical conditions or a distinct progression of the natural history of this complex disease process within each population, which will require prospective studies to better elucidate.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.12.peds22366","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T16:54:33Z","timestamp":1713286473000},"page":"49-56","source":"Crossref","is-referenced-by-count":6,"title":["Multicenter comparison of Chiari malformation type I presentation in children versus adults"],"prefix":"10.3171","volume":"34","author":[{"given":"Armin","family":"Mortazavi","sequence":"first","affiliation":[{"name":"Georgetown University School of Medicine, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil D.","family":"Almeida","sequence":"additional","affiliation":[{"name":"George Washington University School of Medicine and Health Sciences, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s National Medical Center, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Davidson","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s National Medical Center, Washington, DC;"},{"name":"Division of Neurosurgery, Walter Reed National Military Medical Center, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Rotter","sequence":"additional","affiliation":[{"name":"Georgetown University School of Medicine, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany N.","family":"Phan","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s National Medical Center, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deki","family":"Tsering","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s National Medical Center, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Global Neurosciences Institute, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehshua","family":"Karunakaran","sequence":"additional","affiliation":[{"name":"George Washington University School of Medicine and Health Sciences, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Veznedaroglu","sequence":"additional","affiliation":[{"name":"Global Neurosciences Institute, Philadelphia, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Caputy","sequence":"additional","affiliation":[{"name":"George Washington University School of Medicine and Health Sciences, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Heiss","sequence":"additional","affiliation":[{"name":"Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faheem A.","family":"Sandhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, MedStar Georgetown University Hospital, Washington, DC; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Myseros","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s National Medical Center, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chima","family":"Oluigbo","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s National Medical Center, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh N.","family":"Magge","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s National Medical Center, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"Shields","sequence":"additional","affiliation":[{"name":"George Washington University School of Medicine and Health Sciences, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Rosner","sequence":"additional","affiliation":[{"name":"George Washington University School of Medicine and Health Sciences, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire P.","family":"Chatain","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Colorado, Aurora, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Keating","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s National Medical Center, Washington, DC;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"3","key":"b1","series-title":"J Neurosurg Pediatr","first-page":"217","article-title":"The Chiari I malformation","volume":"24","author":"McClugage SG","year":"2019","unstructured":"McClugage SG, Oakes WJ. 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