{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:21:38Z","timestamp":1767612098627},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>The ability to predict final lesion characteristics during magnetic resonance\u2013guided focused ultrasound (MRgFUS) thalamotomy for the treatment of essential tremor remains technically challenging, yet it is essential in order to avoid off-target ablation and to ensure adequate treatment. The authors sought to evaluate the technical feasibility and utility of intraprocedural diffusion-weighted imaging (DWI) in the prediction of final lesion size and location.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Lesion diameter and distance from the midline were measured on both intraprocedural and immediate postprocedural diffusion and T2-weighted sequences. Bland-Altman analysis was utilized to determine differences in measurement between intraprocedural and immediate postprocedural images with both sequences.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Lesion size increased on both the postprocedural diffusion and T2-weighted sequences, although the difference was smaller on the T2-weighted sequence. There was only a small difference in intraprocedural and postprocedural lesion distance from the midline on both the diffusion and T2-weighted sequences.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Intraprocedural DWI is both feasible and useful with regard to predicting final lesion size and providing an early indication of lesion location. Further research should determine the value of intraprocedural DWI in predicting delayed clinical outcomes.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.2.jns222608","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T16:31:56Z","timestamp":1679070716000},"page":"1190-1194","source":"Crossref","is-referenced-by-count":6,"title":["Cranial MRgFUS intraprocedural diffusion and T2 imaging and comparison with postablation lesion size and location"],"prefix":"10.3171","volume":"139","author":[{"given":"Edward J.","family":"Ebani","sequence":"first","affiliation":[{"name":"Departments of Radiology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Strauss","sequence":"additional","affiliation":[{"name":"Departments of Radiology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlene","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Division of Biostatistics, Weill Cornell Medicine, New York; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arindam","family":"RoyChoudhury","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, Division of Biostatistics, Weill Cornell Medicine, New York; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Kaplitt","sequence":"additional","affiliation":[{"name":"Neurological Surgery, Weill Cornell Medicine, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Levi","family":"Chazen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging, Hospital for Special Surgery, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"8","key":"b1","series-title":"N Engl J Med","first-page":"730","article-title":"A randomized trial of focused ultrasound thalamotomy for essential tremor","volume":"375","author":"Elias WJ","year":"2016","unstructured":"Elias WJ, Lipsman N, Ondo WG,  A randomized trial of focused ultrasound thalamotomy for essential tremor. N Engl J Med. 2016;375(8):730\u2013739."},{"issue":"1","key":"b2","series-title":"Brain Sci","first-page":"46","article-title":"Transcranial magnetic resonance imaging-guided focused ultrasound with a 1.5 tesla scanner: a prospective intraindividual comparison study of intraoperative imaging","volume":"11","author":"Gagliardo C","year":"2021","unstructured":"Gagliardo C, Cannella R, D\u2019Angelo C,  Transcranial magnetic resonance imaging-guided focused ultrasound with a 1.5 tesla scanner: a prospective intraindividual comparison study of intraoperative imaging. Brain Sci. 2021;11(1):46."},{"key":"b3","series-title":"World Neurosurg","first-page":"574","article-title":"Cranial MR-guided focused ultrasound: clinical challenges and future directions","volume":"145","author":"Chazen JL","year":"2021","unstructured":"Chazen JL, Stavarache M, Kaplitt MG. Cranial MR-guided focused ultrasound: clinical challenges and future directions. World Neurosurg. 2021;145:574\u2013580."},{"issue":"2","key":"b4","series-title":"Clin Neuroradiol","first-page":"351","article-title":"Cranial MR-guided focused ultrasound for essential tremor: technical considerations and image guidance","volume":"29","author":"Levi Chazen J","year":"2019","unstructured":"Levi Chazen J, Stradford T, Kaplitt MG. Cranial MR-guided focused ultrasound for essential tremor: technical considerations and image guidance. Clin Neuroradiol. 2019;29(2):351\u2013357."},{"issue":"2","key":"b5","series-title":"Neurosurg Focus","first-page":"E5","article-title":"Predicting lesion size during focused ultrasound thalamotomy: a review of 63 lesions over 3 clinical trials","volume":"44","author":"Bond AE","year":"2018","unstructured":"Bond AE, Elias WJ. Predicting lesion size during focused ultrasound thalamotomy: a review of 63 lesions over 3 clinical trials. Neurosurg Focus. 2018;44(2):E5."},{"issue":"1","key":"b6","series-title":"J Magn Reson Imaging","first-page":"136","article-title":"Brain edema development after MRI-guided focused ultrasound treatment","volume":"8","author":"M\u00f3rocz IA","year":"1998","unstructured":"M\u00f3rocz IA, Hynynen K, Gudbjartsson H, Peled S, Colucci V, J\u00f3lesz FA. Brain edema development after MRI-guided focused ultrasound treatment. J Magn Reson Imaging. 1998;8(1):136\u2013142."},{"issue":"4","key":"b7","series-title":"Magn Reson Med","first-page":"2145","article-title":"A preclinical study of diffusion-weighted MRI contrast as an early indicator of thermal ablation","volume":"85","author":"Allen SP","year":"2021","unstructured":"Allen SP, Prada F, Xu Z,  A preclinical study of diffusion-weighted MRI contrast as an early indicator of thermal ablation. Magn Reson Med. 2021;85(4):2145\u20132159."},{"issue":"2","key":"b8","series-title":"J Neurosurg","first-page":"459","article-title":"Intraoperative lesion characterization after focused ultrasound thalamotomy","volume":"137","author":"Sammartino F","year":"2022","unstructured":"Sammartino F, Yeh FC, Krishna V. Intraoperative lesion characterization after focused ultrasound thalamotomy. J Neurosurg. 2022;137(2):459\u2013467."},{"issue":"2","key":"b9","series-title":"J Neurosurg","first-page":"307","article-title":"A magnetic resonance imaging, histological, and dose modeling comparison of focused ultrasound, radiofrequency, and Gamma Knife radiosurgery lesions in swine thalamus","volume":"119","author":"Elias WJ","year":"2013","unstructured":"Elias WJ, Khaled M, Hilliard JD,  A magnetic resonance imaging, histological, and dose modeling comparison of focused ultrasound, radiofrequency, and Gamma Knife radiosurgery lesions in swine thalamus. J Neurosurg. 2013;119(2):307\u2013317."},{"issue":"8","key":"b10","series-title":"Mov Disord","first-page":"1165","article-title":"Cost-effectiveness of focused ultrasound, radiosurgery, and DBS for essential tremor","volume":"32","author":"Ravikumar VK","year":"2017","unstructured":"Ravikumar VK, Parker JJ, Hornbeck TS,  Cost-effectiveness of focused ultrasound, radiosurgery, and DBS for essential tremor. Mov Disord. 2017;32(8):1165\u20131173."},{"issue":"10","key":"b11","series-title":"Brain","first-page":"3089","article-title":"Lesion location and lesion creation affect outcomes after focused ultrasound thalamotomy","volume":"144","author":"Segar DJ","year":"2021","unstructured":"Segar DJ, Lak AM, Lee S,  Lesion location and lesion creation affect outcomes after focused ultrasound thalamotomy. Brain. 2021;144(10):3089\u20133100."},{"issue":"11","key":"b12","series-title":"Neurol Med Chir (Tokyo)","first-page":"629","article-title":"Techniques, indications, and outcomes in magnetic resonance-guided focused ultrasound thalamotomy for tremor","volume":"61","author":"Maesawa S","year":"2021","unstructured":"Maesawa S, Nakatsubo D, Tsugawa T,  Techniques, indications, and outcomes in magnetic resonance-guided focused ultrasound thalamotomy for tremor. Neurol Med Chir (Tokyo). 2021;61(11):629\u2013639."},{"issue":"4","key":"b13","series-title":"Neurosurgery","first-page":"751","article-title":"Focused ultrasound thalamotomy for refractory essential tremor: a Japanese multicenter single-arm study","volume":"88","author":"Abe K","year":"2021","unstructured":"Abe K, Horisawa S, Yamaguchi T,  Focused ultrasound thalamotomy for refractory essential tremor: a Japanese multicenter single-arm study. Neurosurgery. 2021;88(4):751\u2013757."},{"issue":"2","key":"b14","series-title":"J Neurosurg","first-page":"417","article-title":"Magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: a 5-year single-center experience","volume":"133","author":"Sinai A","year":"2020","unstructured":"Sinai A, Nassar M, Eran A,  Magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: a 5-year single-center experience. J Neurosurg. 2020;133(2):417\u2013424."},{"issue":"10","key":"b15","series-title":"Mov Disord","first-page":"1647","article-title":"Magnetic resonance-guided focused ultrasound thalamotomy for treatment of essential tremor: a 2-year outcome study","volume":"33","author":"Meng Y","year":"2018","unstructured":"Meng Y, Solomon B, Boutet A,  Magnetic resonance-guided focused ultrasound thalamotomy for treatment of essential tremor: a 2-year outcome study. Mov Disord. 2018;33(10):1647\u20131650."},{"issue":"2","key":"b16","series-title":"Neurosurg Focus","first-page":"E4","article-title":"A meta-analysis of outcomes and complications of magnetic resonance-guided focused ultrasound in the treatment of essential tremor","volume":"44","author":"Mohammed N","year":"2018","unstructured":"Mohammed N, Patra D, Nanda A. A meta-analysis of outcomes and complications of magnetic resonance-guided focused ultrasound in the treatment of essential tremor. Neurosurg Focus. 2018;44(2):E4."},{"issue":"2","key":"b17","series-title":"Neurosurgery","first-page":"229","article-title":"Predictors of outcomes after focused ultrasound thalamotomy","volume":"87","author":"Krishna V","year":"2020","unstructured":"Krishna V, Sammartino F, Cosgrove R,  Predictors of outcomes after focused ultrasound thalamotomy. Neurosurgery. 2020;87(2):229\u2013237."},{"issue":"1","key":"b18","series-title":"Neurosurgery","first-page":"160","article-title":"Prospective tractography-based targeting for improved safety of focused ultrasound thalamotomy","volume":"84","author":"Krishna V","year":"2019","unstructured":"Krishna V, Sammartino F, Agrawal P,  Prospective tractography-based targeting for improved safety of focused ultrasound thalamotomy. Neurosurgery. 2019;84(1):160\u2013168."},{"issue":"4","key":"b19","series-title":"Neurosurgery","first-page":"610","article-title":"Thermal neuromodulation with focused ultrasound: implications for the technique of subthreshold testing","volume":"89","author":"Sammartino F","year":"2021","unstructured":"Sammartino F, Snell J, Eames M, Krishna V. Thermal neuromodulation with focused ultrasound: implications for the technique of subthreshold testing. Neurosurgery. 2021;89(4):610\u2013616."},{"issue":"2","key":"b20","series-title":"Neurosurg Focus","first-page":"E7","article-title":"Preliminary experience with a transcranial magnetic resonance-guided focused ultrasound surgery system integrated with a 1.5-T MRI unit in a series of patients with essential tremor and Parkinson\u2019s disease","volume":"44","author":"Iacopino DG","year":"2018","unstructured":"Iacopino DG, Gagliardo C, Giugno A,  Preliminary experience with a transcranial magnetic resonance-guided focused ultrasound surgery system integrated with a 1.5-T MRI unit in a series of patients with essential tremor and Parkinson\u2019s disease. Neurosurg Focus. 2018;44(2):E7."},{"issue":"9","key":"b21","series-title":"Eur Radiol","first-page":"5059","article-title":"Intraoperative imaging findings in transcranial MR imaging-guided focused ultrasound treatment at 1.5T may accurately detect typical lesional findings correlated with sonication parameters","volume":"30","author":"Gagliardo C","year":"2020","unstructured":"Gagliardo C, Cannella R, Quarrella C,  Intraoperative imaging findings in transcranial MR imaging-guided focused ultrasound treatment at 1.5T may accurately detect typical lesional findings correlated with sonication parameters. Eur Radiol. 2020;30(9):5059\u20135070."},{"issue":"4","key":"b22","series-title":"Oper Neurosurg (Hagerstown)","first-page":"376","article-title":"Focused ultrasound thalamotomy for essential tremor in the setting of a ventricular shunt: technical report","volume":"17","author":"Yang AI","year":"2019","unstructured":"Yang AI, Chaibainou H, Wang S,  Focused ultrasound thalamotomy for essential tremor in the setting of a ventricular shunt: technical report. Oper Neurosurg (Hagerstown). 2019;17(4):376\u2013381."},{"issue":"3","key":"b23","series-title":"Radiographics","first-page":"849","article-title":"An image-based approach to understanding the physics of MR artifacts","volume":"31","author":"Morelli JN","year":"2011","unstructured":"Morelli JN, Runge VM, Ai F,  An image-based approach to understanding the physics of MR artifacts. Radiographics. 2011;31(3):849\u2013866."},{"issue":"4","key":"b24","series-title":"Magn Reson Imaging Clin N Am","first-page":"717","article-title":"MR imaging artifacts. Challenges and solutions","volume":"7","author":"Mirowitz SA","year":"1999","unstructured":"Mirowitz SA. MR imaging artifacts. Challenges and solutions. Magn Reson Imaging Clin N Am. 1999;7(4):717\u2013732."},{"issue":"1","key":"b25","series-title":"Quant Imaging Med Surg","first-page":"21","article-title":"Towards fast and accurate temperature mapping with proton resonance frequency-based MR thermometry","volume":"2","author":"Yuan J","year":"2012","unstructured":"Yuan J, Mei CS, Panych LP, McDannold NJ, Madore B. Towards fast and accurate temperature mapping with proton resonance frequency-based MR thermometry. Quant Imaging Med Surg. 2012;2(1):21\u201332."},{"issue":"5","key":"b26","series-title":"AJNR Am J Neuroradiol","first-page":"891","article-title":"Imaging findings in MR imaging-guided focused ultrasound treatment for patients with essential tremor","volume":"35","author":"Wintermark M","year":"2014","unstructured":"Wintermark M, Druzgal J, Huss DS,  Imaging findings in MR imaging-guided focused ultrasound treatment for patients with essential tremor. AJNR Am J Neuroradiol. 2014;35(5):891\u2013896."},{"issue":"9","key":"b27","series-title":"Neuroradiology","first-page":"1111","article-title":"MRI follow-up after magnetic resonance-guided focused ultrasound for non-invasive thalamotomy: the neuroradiologist\u2019s perspective","volume":"62","author":"Keil VC","year":"2020","unstructured":"Keil VC, Borger V, Purrer V,  MRI follow-up after magnetic resonance-guided focused ultrasound for non-invasive thalamotomy: the neuroradiologist\u2019s perspective. Neuroradiology. 2020;62(9):1111\u20131122."},{"key":"b28","series-title":"Front Neurol","first-page":"1069","article-title":"Acute MR-guided high-intensity focused ultrasound lesion assessment using diffusion-weighted imaging and histological analysis","volume":"10","author":"Walker MR","year":"2019","unstructured":"Walker MR, Zhong J, Waspe AC,  Acute MR-guided high-intensity focused ultrasound lesion assessment using diffusion-weighted imaging and histological analysis. Front Neurol. 2019;10:1069."}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/139\/4\/article-p1190.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/139\/4\/article-p1190.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/139\/4\/article-p1190.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T10:49:15Z","timestamp":1716029355000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/139\/4\/article-p1190.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,1]]},"references-count":28,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/2023.2.jns222608","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,1]]}}}