{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T04:22:03Z","timestamp":1772511723534,"version":"3.50.1"},"reference-count":39,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Since the publication of A Randomized Trial of Unruptured Brain AVMs (ARUBA), the management of unruptured brain arteriovenous malformations (bAVMs) has been controversially discussed. Long-term follow-up data on the exclusively conservative management of unruptured bAVMs are scarce. The authors evaluated the long-term outcomes of patients with unruptured untreated bAVMs in a real-life cohort.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>A retrospective observational cohort of 107 patients (of 897 bAVM patients referred to the authors\u2019 institution) with a diagnosis of unruptured and conservatively managed bAVMs is presented. AVMs of all Spetzler-Martin grades were observed. The mean follow-up period was 84 months. In 44% of patients, a follow-up period of 5 years or longer was observed. A national death register comparison completed the outcome analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The median age at diagnosis, sex distribution, neurological presentation, and modified Rankin Scale score were comparable to the patients in the medical management arm of the ARUBA study. Patients were mainly young, predominantly male, and in good clinical condition. Similar to the ARUBA cohort, 77% of this study\u2019s cohort presented in an excellent clinical status at the time of last follow-up. However, 17% of patients had at least one hemorrhage, resulting in an overall annual hemorrhage risk of 2.7% in the observation period. Moreover, the cumulative 1-, 5-, and 10-year overall hemorrhage rates were 3.0%, 11.3%, and 15.3%, respectively. Consequently, the long-term follow-up AVM-related mortality rate amounted to 8%. The estimated median overall survival after AVM diagnosis was 19.3 years (95% CI 14.0\u201324.6 years). A multivariate Cox regression model revealed temporal and deep-seated localization as an independent risk factor for AVM hemorrhage, while the presence of seizures reached borderline significance as a risk factor.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>The authors\u2019 results represent the long-term course of unruptured untreated bAVMs. Their data support the conclusion that even in the post-ARUBA era, tailored active treatment options may be offered to patients with unruptured bAVMs. For patient counseling, individual risk factors should be weighed against the center\u2019s treatment-specific risks.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.2.jns222675","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T16:45:36Z","timestamp":1679676336000},"page":"1025-1035","source":"Crossref","is-referenced-by-count":4,"title":["Outcome of 107 conservatively managed unruptured brain arteriovenous malformations: a single center\u2019s 30-year experience"],"prefix":"10.3171","volume":"139","author":[{"given":"Philippe","family":"Dodier","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Medical University of Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate","family":"Kranawetter","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorian","family":"Hirschmann","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammet","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Untersteiner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"G\u00f6bl","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Gatterbauer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Te","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Dorfer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"R\u00f6ssler","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Bavinzski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josa M.","family":"Frischer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical University of Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"4","key":"b1","series-title":"J Neurosurg Sci","first-page":"437","article-title":"Natural history of brain arteriovenous malformations: systematic review","volume":"62","author":"Goldberg J","year":"2018","unstructured":"Goldberg J, Raabe A, Bervini D. 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