{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:54:52Z","timestamp":1792853692355,"version":"4.5.0"},"reference-count":66,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>The goal of this study was to provide a comprehensive overview of the current understanding of molecular and genetic mechanisms underlying the pathophysiology of trigeminal neuralgia (TN).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>The authors searched PubMed systematically for primary research literature investigating specific molecular mechanisms from samples derived from patients with TN. The genes\/molecules of interest from the selected literature were then cross-referenced with corresponding studies in animal models of TN.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>From approximately 345 articles, a total of 12 articles were selected and included in the review, focusing on ionotropic channel expressivity and mutations, reactive oxygen species expressivity, inflammatory marker expressivity, and microRNA expressivity. Of the 12 included articles, only 4 had studies completed in other animal models regarding the corresponding TN mechanism found in humans.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS <\/jats:title>\n<jats:p>The current literature does not suggest a conclusive disease mechanism for TN in humans. In addition to neurovascular conflict\/compression of the trigeminal nerve, recent studies have indicated that TN may be linked to inflammatory and reactive oxygen species signaling as well. Recent genetic studies in patients with TN have yet to be investigated further in animal models.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.2.jns23274","type":"journal-article","created":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:20:43Z","timestamp":1680308443000},"page":"1471-1479","source":"Crossref","is-referenced-by-count":26,"title":["The pathophysiology of trigeminal neuralgia: a molecular review"],"prefix":"10.3171","volume":"139","author":[{"given":"Bryan","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Mol Pain","first-page":"1744806920901890","article-title":"Trigeminal neuralgia: an overview from pathophysiology to pharmacological treatments","volume":"16","author":"Gambeta E","year":"2020","unstructured":"Gambeta E, Chichorro JG, Zamponi GW. Trigeminal neuralgia: an overview from pathophysiology to pharmacological treatments. Mol Pain. 2020;16:1744806920901890."},{"issue":"4","key":"b2","series-title":"Asian J Neurosurg","first-page":"585","article-title":"Trigeminal neuralgia","volume":"12","author":"Yadav YR","year":"2017","unstructured":"Yadav YR, Nishtha Y, Sonjjay P, Vijay P, Shailendra R, Yatin K. Trigeminal neuralgia. Asian J Neurosurg. 2017;12(4):585\u2013597."},{"issue":"2","key":"b3","series-title":"Neurology","first-page":"220","article-title":"Trigeminal neuralgia: new classification and diagnostic grading for practice and research","volume":"87","author":"Cruccu G","year":"2016","unstructured":"Cruccu G, Finnerup NB, Jensen TS,  Trigeminal neuralgia: new classification and diagnostic grading for practice and research. Neurology. 2016;87(2):220\u2013228."},{"key":"b4","series-title":"J Pain Res","first-page":"3437","article-title":"Trigeminal neuralgia: current approaches and emerging interventions","volume":"14","author":"Xu R","year":"2021","unstructured":"Xu R, Xie ME, Jackson CM. Trigeminal neuralgia: current approaches and emerging interventions. J Pain Res. 2021;14:3437\u20133463."},{"key":"b5","series-title":"Clin Neurol Neurosurg","first-page":"106397","article-title":"Molecular mechanisms of trigeminal neuralgia: a systematic review","volume":"200","author":"Smith CA","year":"2021","unstructured":"Smith CA, Paskhover B, Mammis A. Molecular mechanisms of trigeminal neuralgia: a systematic review. Clin Neurol Neurosurg. 2021;200:106397."},{"issue":"10","key":"b6","series-title":"Curr Pain Headache Rep","first-page":"74","article-title":"A comprehensive review of trigeminal neuralgia","volume":"23","author":"Jones MR","year":"2019","unstructured":"Jones MR, Urits I, Ehrhardt KP,  A comprehensive review of trigeminal neuralgia. Curr Pain Headache Rep. 2019;23(10):74."},{"key":"b7","series-title":"Neurosurgery","article-title":"Multiple vessel compression of the trigeminal nerve is associated with worse outcomes in trigeminal neuralgia after microvascular decompression","author":"So RJ","unstructured":"So RJ, Kalluri AL, Zhu S,  Multiple vessel compression of the trigeminal nerve is associated with worse outcomes in trigeminal neuralgia after microvascular decompression. Neurosurgery.  Published online December 30, 2022. doi:10.1227\/neu.0000000000002323"},{"issue":"5","key":"b8","series-title":"J Neurosurg","first-page":"799","article-title":"Demonstration of neurovascular compression in trigeminal neuralgia with magnetic resonance imaging. Comparison with surgical findings in 52 consecutive operative cases","volume":"83","author":"Meaney JF","year":"1995","unstructured":"Meaney JF, Eldridge PR, Dunn LT, Nixon TE, Whitehouse GH, Miles JB. Demonstration of neurovascular compression in trigeminal neuralgia with magnetic resonance imaging. Comparison with surgical findings in 52 consecutive operative cases. J Neurosurg. 1995;83(5):799\u2013805."},{"issue":"5","key":"b9","series-title":"J Neurosurg","first-page":"1048","article-title":"Trigeminal neuralgia occurs and recurs in the absence of neurovascular compression","volume":"120","author":"Lee A","year":"2014","unstructured":"Lee A, McCartney S, Burbidge C, Raslan AM, Burchiel KJ. Trigeminal neuralgia occurs and recurs in the absence of neurovascular compression. J Neurosurg. 2014;120(5):1048\u20131054."},{"issue":"1","key":"b10","series-title":"J Neurosurg","first-page":"270","article-title":"Internal neurolysis versus intraoperative glycerin rhizotomy for trigeminal neuralgia","volume":"138","author":"Xu R","year":"2022","unstructured":"Xu R, Materi J, Raj D,  Internal neurolysis versus intraoperative glycerin rhizotomy for trigeminal neuralgia. J Neurosurg. 2022;138(1):270\u2013275."},{"issue":"8","key":"b11","series-title":"Pain","first-page":"1464","article-title":"Magnetic resonance imaging contribution for diagnosing symptomatic neurovascular contact in classical trigeminal neuralgia: a blinded case-control study and meta-analysis","volume":"155","author":"Antonini G","year":"2014","unstructured":"Antonini G, Di Pasquale A, Cruccu G,  Magnetic resonance imaging contribution for diagnosing symptomatic neurovascular contact in classical trigeminal neuralgia: a blinded case-control study and meta-analysis. Pain. 2014;155(8):1464\u20131471."},{"issue":"11","key":"b12","series-title":"J Clin Invest","first-page":"3745","article-title":"Pain as a channelopathy","volume":"120","author":"Raouf R","year":"2010","unstructured":"Raouf R, Quick K, Wood JN. Pain as a channelopathy. J Clin Invest. 2010;120(11):3745\u20133752."},{"issue":"7121","key":"b13","series-title":"Nature","first-page":"894","article-title":"An SCN9A channelopathy causes congenital inability to experience pain","volume":"444","author":"Cox JJ","year":"2006","unstructured":"Cox JJ, Reimann F, Nicholas AK,  An SCN9A channelopathy causes congenital inability to experience pain. Nature. 2006;444(7121):894\u2013898."},{"issue":"7","key":"b14","series-title":"Pain Med","first-page":"1362","article-title":"No association of polymorphisms in Nav1.7 or nerve growth factor receptor genes with trigeminal neuralgia","volume":"20","author":"Costa GMF","year":"2019","unstructured":"Costa GMF, Rocha LPC, Siqueira SRDT, Moreira PR, Almeida-Leite CM. No association of polymorphisms in Nav1.7 or nerve growth factor receptor genes with trigeminal neuralgia. Pain Med. 2019;20(7):1362\u20131369."},{"key":"b15","series-title":"Clin Neurol Neurosurg","first-page":"106880","article-title":"Polymorphisms of Nav1.6 sodium channel, brain-derived neurotrophic factor, catechol-O-methyltransferase and guanosine triphosphate cyclohydrolase 1 genes in trigeminal neuralgia","volume":"208","author":"Romero J","year":"2021","unstructured":"Romero J, Costa GMF, Rocha LPC, Siqueira S, Moreira PR, Almeida-Leite CM. Polymorphisms of Nav1.6 sodium channel, brain-derived neurotrophic factor, catechol-O-methyltransferase and guanosine triphosphate cyclohydrolase 1 genes in trigeminal neuralgia. Clin Neurol Neurosurg. 2021;208:106880."},{"issue":"4","key":"b16","series-title":"Lancet Neurol","first-page":"291","article-title":"Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial","volume":"16","author":"Zakrzewska JM","year":"2017","unstructured":"Zakrzewska JM, Palmer J, Morisset V,  Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial. Lancet Neurol. 2017;16(4):291\u2013300."},{"issue":"8","key":"b17","series-title":"Cephalalgia","first-page":"767","article-title":"Familial trigeminal neuralgia\u2014a systematic clinical study with a genomic screen of the neuronal electrogenisome","volume":"40","author":"Di Stefano G","year":"2020","unstructured":"Di Stefano G, Yuan JH, Cruccu G, Waxman SG, Dib-Hajj SD, Truini A. 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Pain. 2022;163(12):2315\u20132325."},{"issue":"1","key":"b20","series-title":"Neurol Genet","first-page":"e550","article-title":"Trigeminal neuralgia TRPM8 mutation: enhanced activation, basal [Ca2+]i and menthol response","volume":"7","author":"Gualdani R","year":"2021","unstructured":"Gualdani R, Yuan JH, Effraim PR,  Trigeminal neuralgia TRPM8 mutation: enhanced activation, basal [Ca2+]i and menthol response. Neurol Genet. 2021;7(1):e550."},{"issue":"38","key":"b21","series-title":"Proc Natl Acad Sci U S A","first-page":"e2119630119","article-title":"A TRPM7 mutation linked to familial trigeminal neuralgia: omega current and hyperexcitability of trigeminal ganglion neurons","volume":"119","author":"Gualdani R","year":"2022","unstructured":"Gualdani R, Gailly P, Yuan JH,  A TRPM7 mutation linked to familial trigeminal neuralgia: omega current and hyperexcitability of trigeminal ganglion neurons. Proc Natl Acad Sci U S A. 2022;119(38):e2119630119."},{"issue":"10","key":"b22","series-title":"J Dent Res","first-page":"1183","article-title":"Antinociceptive effects of botulinum toxin type A on trigeminal neuropathic pain","volume":"95","author":"Yang KY","year":"2016","unstructured":"Yang KY, Kim MJ, Ju JS,  Antinociceptive effects of botulinum toxin type A on trigeminal neuropathic pain. J Dent Res. 2016;95(10):1183\u20131190."},{"issue":"1","key":"b23","series-title":"Mol Med","first-page":"338","article-title":"A gain-of-function mutation in Nav1.6 in a case of trigeminal neuralgia","volume":"22","author":"Tanaka BS","year":"2016","unstructured":"Tanaka BS, Zhao P, Dib-Hajj FB,  A gain-of-function mutation in Nav1.6 in a case of trigeminal neuralgia. 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Front Physiol. 2018;9:95."},{"issue":"31","key":"b28","series-title":"Sci Adv","first-page":"eabo5633","article-title":"Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain","volume":"8","author":"Vasavda C","year":"2022","unstructured":"Vasavda C, Xu R, Liew J,  Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Sci Adv. 2022;8(31):eabo5633."},{"issue":"4","key":"b29","series-title":"J Comp Neurol","first-page":"596","article-title":"Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta\/c-fibers and colocalization with trk receptors","volume":"493","author":"Kobayashi K","year":"2005","unstructured":"Kobayashi K, Fukuoka T, Obata K,  Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta\/c-fibers and colocalization with trk receptors. J Comp Neurol. 2005;493(4):596\u2013606."},{"issue":"2","key":"b30","series-title":"Neuron","first-page":"277","article-title":"TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction","volume":"50","author":"Kwan KY","year":"2006","unstructured":"Kwan KY, Allchorne AJ, Vollrath MA,  TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron. 2006;50(2):277\u2013289."},{"issue":"10","key":"b31","series-title":"J Neurosci","first-page":"2485","article-title":"Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress","volume":"28","author":"Andersson DA","year":"2008","unstructured":"Andersson DA, Gentry C, Moss S, Bevan S. Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci. 2008;28(10):2485\u20132494."},{"issue":"33","key":"b32","series-title":"Proc Natl Acad Sci U S A","first-page":"13519","article-title":"4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1","volume":"104","author":"Trevisani M","year":"2007","unstructured":"Trevisani M, Siemens J, Materazzi S,  4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A. 2007;104(33):13519\u201313524."},{"issue":"48","key":"b33","series-title":"Medicine (Baltimore)","first-page":"e22972","article-title":"Evaluation of circulating microRNA expression in patients with trigeminal neuralgia: an observational study","volume":"99","author":"Li X","year":"2020","unstructured":"Li X, Wang D, Zhou J, Yan Y, Chen L. Evaluation of circulating microRNA expression in patients with trigeminal neuralgia: an observational study. Medicine (Baltimore). 2020;99(48):e22972."},{"issue":"5","key":"b34","series-title":"J Pain","first-page":"526","article-title":"TRPA1 and TRPV1 antagonists do not inhibit human acidosis-induced pain","volume":"18","author":"Schwarz MG","year":"2017","unstructured":"Schwarz MG, Namer B, Reeh PW, Fischer MJM. TRPA1 and TRPV1 antagonists do not inhibit human acidosis-induced pain. J Pain. 2017;18(5):526\u2013534."},{"issue":"4","key":"b35","series-title":"Pharmaceuticals (Basel)","first-page":"117","article-title":"TRPA1 antagonists for pain relief","volume":"11","author":"Koivisto A","year":"2018","unstructured":"Koivisto A, Jalava N, Bratty R, Pertovaara A. TRPA1 antagonists for pain relief. Pharmaceuticals (Basel). 2018;11(4):117."},{"issue":"1","key":"b36","series-title":"Nat Rev Drug Discov","first-page":"41","article-title":"Advances in TRP channel drug discovery: from target validation to clinical studies","volume":"21","author":"Koivisto AP","year":"2022","unstructured":"Koivisto AP, Belvisi MG, Gaudet R, Szallasi A. Advances in TRP channel drug discovery: from target validation to clinical studies. Nat Rev Drug Discov. 2022;21(1):41\u201359."},{"issue":"1","key":"b37","series-title":"Genes Dev","first-page":"76","article-title":"Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain","volume":"13","author":"Itoh K","year":"1999","unstructured":"Itoh K, Wakabayashi N, Katoh Y,  Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. 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Pain. 2019;160(11):2603\u20132611."},{"issue":"4","key":"b50","series-title":"Neurol Res","first-page":"335","article-title":"A correlative analysis between inflammatory cytokines and trigeminal neuralgia or hemifacial spasm","volume":"41","author":"Liu MX","year":"2019","unstructured":"Liu MX, Zhong J, Xia L, Dou NN, Li ST. A correlative analysis between inflammatory cytokines and trigeminal neuralgia or hemifacial spasm. Neurol Res. 2019;41(4):335\u2013340."},{"key":"b51","series-title":"Front Cell Neurosci","first-page":"764141","article-title":"The up-regulation of TNF-\u03b1 maintains trigeminal neuralgia by modulating MAPKs phosphorylation and BKCa channels in trigeminal nucleus caudalis","volume":"15","author":"Lu ZY","year":"2021","unstructured":"Lu ZY, Fan J, Yu LH, Ma B, Cheng LM. The up-regulation of TNF-\u03b1 maintains trigeminal neuralgia by modulating MAPKs phosphorylation and BKCa channels in trigeminal nucleus caudalis. 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Mol Pain. 2020;16:1744806920980538."},{"issue":"2","key":"b60","series-title":"Pain Physician","first-page":"187","article-title":"An animal model for trigeminal neuralgia by compression of the trigeminal nerve root","volume":"15","author":"Luo DS","year":"2012","unstructured":"Luo DS, Zhang T, Zuo CX,  An animal model for trigeminal neuralgia by compression of the trigeminal nerve root. Pain Physician. 2012;15(2):187\u2013196."},{"issue":"8","key":"b61","series-title":"Neurochem Res","first-page":"1893","article-title":"Glial plasticity in the trigeminal root entry zone of a rat trigeminal neuralgia animal model","volume":"44","author":"Luo D","year":"2019","unstructured":"Luo D, Lin R, Luo L,  Glial plasticity in the trigeminal root entry zone of a rat trigeminal neuralgia animal model. 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J Headache Pain. 2019;20(1):20."},{"issue":"suppl 1","key":"b64","series-title":"Neurosurgery","first-page":"36","article-title":"Genome-wide association study reveals genetic risk factors for trigeminal neuralgia","volume":"68","author":"Hale AT","year":"2022","unstructured":"Hale AT, Akinnusotu O, He J,  Genome-wide association study reveals genetic risk factors for trigeminal neuralgia. Neurosurgery. 2022;68(suppl 1):36\u201337."},{"issue":"2","key":"b65","series-title":"Neuroscience","first-page":"573","article-title":"Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia","volume":"164","author":"Siqueira SR","year":"2009","unstructured":"Siqueira SR, Alves B, Malpartida HM, Teixeira MJ, Siqueira JT. Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia. 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