{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T13:54:12Z","timestamp":1771509252465,"version":"3.50.1"},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Delayed cerebral ischemia (DCI) associated with vasospasm is well described in the setting of aneurysmal subarachnoid hemorrhage (SAH). In addition, DCI is very infrequently encountered in patients who have undergone resection of a brain tumor with unclear pathophysiology. The occurrence of DCI in the pediatric population is exceedingly rare, and outcomes in this population have, to the authors\u2019 knowledge, never been systematically reviewed. Therefore, the authors present what is to their knowledge the largest series of pediatric patients with this complication and systematically reviewed the literature for individual participant data.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>The authors conducted a retrospective review of 172 sellar and suprasellar tumors in pediatric patients who underwent surgery at the Montreal Children\u2019s Hospital between 1999 and 2017 to identify cases of vasospasm occurring after tumor resection. Descriptive statistics, including patient characteristics, intraoperative and postoperative findings, and outcome status, were collected. A systematic review was also conducted using three databases (PubMed, Web of Science, Embase) to identify reported cases available in the literature of vasospasm after tumor resection in children and collect individual participant data on these patients for further analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Six patients treated at Montreal Children\u2019s Hospital were identified, with an average age of 9.5 years (range 6\u201315 years). The prevalence of vasospasm after tumor resection was 3.5% (6\/172). Vasospasm in all 6 patients occurred after craniotomy was performed to treat a suprasellar tumor. The average interval from surgery to symptoms was 3.25 days (range 12 hours\u201310 days). The most common tumor etiology was craniopharyngioma, seen in 4 cases. Extensive tumor encasement of blood vessels requiring significant operative manipulation was described in all 6 patients. A rapid decrease in serum sodium (exceeding 12 mEq\/L\/24 hrs or below 135 mEq\/L) was seen in 4 patients. On final follow-up, 3 patients were left with significant disability, and all patients had persistent deficits. A systematic review of the literature revealed a total of 10 other patients whose characteristics and treatment were compared with those of the 6 patients treated at Montreal Children\u2019s Hospital.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Vasospasm after tumor resection in children and youth is likely a rare entity, with a prevalence of 3.5% in this case series. Suprasellar tumor location (particularly craniopharyngioma tumor etiology), significant encasement of blood vessels by the tumor, and postoperative hyponatremia may be predictive factors. Outcome is poor, with most patients having significant persistent neurological deficits.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.3.peds22373","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T18:52:45Z","timestamp":1686423165000},"page":"343-350","source":"Crossref","is-referenced-by-count":4,"title":["Vasospasm following brain tumor resection in children: institutional experience and systematic review"],"prefix":"10.3171","volume":"32","author":[{"given":"Rakan","family":"Bokhari","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia;"},{"name":"Department of Neurology and Neurosurgery, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lior M.","family":"Elkaim","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan A.","family":"Shlobin","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naif M.","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulrahman J.","family":"Sabbagh","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander G.","family":"Weil","sequence":"additional","affiliation":[{"name":"Division of Surgery, St-Justine University Hospital, Montr\u00e9al, Qu\u00e9bec, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleh","family":"Baeesa","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy W. R.","family":"Dudley","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada;"},{"name":"Department of Paediatric Surgery, McGill University Health Centre, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada;"},{"name":"Department of Paediatric Surgery, McGill University Health Centre, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Farmer","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada;"},{"name":"Department of Paediatric Surgery, McGill University Health Centre, McGill University, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"Can J Neurol Sci","first-page":"15","article-title":"Cerebral vasospasm: a review","volume":"43","author":"Findlay JM","year":"2016","unstructured":"Findlay JM, Nisar J, Darsaut T. 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J Clin Invest. 1994;93(1):256\u2013264."}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/32\/3\/article-p343.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/32\/3\/article-p343.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/32\/3\/article-p343.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T13:02:13Z","timestamp":1733490133000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/32\/3\/article-p343.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,1]]},"references-count":24,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/2023.3.peds22373","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,1]]}}}