{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:02:28Z","timestamp":1782957748921,"version":"3.54.5"},"reference-count":37,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Mutations in <jats:italic>NF2<\/jats:italic> are the most common somatic driver mutation in sporadic meningiomas. <jats:italic>NF2<\/jats:italic> mutant meningiomas preferentially arise along the cerebral convexities\u2014however, they can also be found in the posterior fossa. The authors investigated whether <jats:italic>NF2<\/jats:italic> mutant meningiomas differ in clinical and genomic features based on their location relative to the tentorium.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Clinical and whole exome sequencing (WES) data for patients who underwent resection of sporadic <jats:italic>NF2<\/jats:italic> mutant meningiomas were reviewed and analyzed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>A total of 191 <jats:italic>NF2<\/jats:italic> mutant meningiomas were included (165 supratentorial, 26 infratentorial). Supratentorial <jats:italic>NF2<\/jats:italic> mutant meningiomas were significantly associated with edema (64.0% vs 28.0%, p &lt; 0.001); higher grade\u2014i.e., WHO grade II or III (41.8% vs 3.9%, p &lt; 0.001); elevated Ki-67 (55.0% vs 13.6%, p &lt; 0.001); and larger volume (mean 45.5 cm<jats:sup>3<\/jats:sup> vs 14.9 cm<jats:sup>3<\/jats:sup>, p &lt; 0.001). Furthermore, supratentorial tumors were more likely to harbor the higher-risk feature of chromosome 1p deletion (p = 0.038) and had a larger fraction of the genome altered with loss of heterozygosity (p &lt; 0.001). Infratentorial meningiomas were more likely to undergo subtotal resection than supratentorial tumors (37.5% vs 15.8%, p = 0.021); however, there was no significant difference in overall (p = 0.2) or progression-free (p = 0.4) survival.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Supratentorial <jats:italic>NF2<\/jats:italic> mutant meningiomas are associated with more aggressive clinical and genomic features as compared with their infratentorial counterparts. Although infratentorial tumors have higher rates of subtotal resection, there is no associated difference in survival or recurrence. These findings help to better inform surgical decision-making in the management of <jats:italic>NF2<\/jats:italic> mutant meningiomas based on location, and may guide postoperative management of these tumors.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.4.jns222929","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T14:44:32Z","timestamp":1685198672000},"page":"1648-1656","source":"Crossref","is-referenced-by-count":5,"title":["Clinical and genomic differences in supratentorial versus infratentorial NF2 mutant meningiomas"],"prefix":"10.3171","volume":"139","author":[{"given":"Joanna K.","family":"Tabor","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Vasandani","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaurey","family":"Vetsa","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyi","family":"Lei","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad I.","family":"Jalal","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelan J.","family":"Marianayagam","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Jin","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Millares Chavez","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Haynes","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Dincer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tufts Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanat","family":"Yalcin","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Aguilera","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sacit Bulent","family":"Omay","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketu","family":"Mishra-Gorur","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan","family":"McGuone","sequence":"additional","affiliation":[{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"},{"name":"Pathology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul F.","family":"Morales-Valero","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Fulbright","sequence":"additional","affiliation":[{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"},{"name":"Radiology and Biomedical Imaging, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Gunel","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"The Ch\u00eanevert Family Brain Tumor Center, Smilow Cancer Hospital, New Haven, Connecticut; and"},{"name":"Genetics, Yale School of Medicine, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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