{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T18:03:24Z","timestamp":1747332204491,"version":"3.30.1"},"reference-count":14,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Vertebral osteomyelitis is a rare complication of coccidioidomycosis infection. Surgical intervention is indicated when there is failure of medical management or presence of neurological deficit, epidural abscess, or spinal instability. The relationship between timing of surgical intervention and recovery of neurological function has not been previously described. The purpose of this study was to investigate if the duration of neurological deficits at presentation affects neurological recovery after surgical intervention.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>This was a retrospective study of all patients diagnosed with coccidioidomycosis involving the spine at a single tertiary care center between 2012 and 2021. Data collected included patient demographics, clinical presentation, radiographic information, and surgical intervention. The primary outcome was change in neurological examination after surgical intervention, quantified according to the American Spinal Injury Association Impairment Scale. The secondary outcome was the complication rate. Logistic regression was used to test if the duration of neurological deficits was associated with improvement in the neurological examination after surgery.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Twenty-seven patients presented with spinal coccidioidomycosis between 2012 and 2021; 20 of these patients had vertebral involvement on spinal imaging with a median follow-up of 8.7 months (IQR 1.7\u201371.2 months). Of the 20 patients with vertebral involvement, 12 (60.0%) presented with a neurological deficit with a median duration of 20 days (range 1\u201361 days). Most patients presenting with neurological deficit (11\/12, 91.7%) underwent surgical intervention. Nine (81.2%) of these 11 patients had an improved neurological examination after surgery and the other 2 had stable deficits. Seven patients had improved recovery sufficient to improve by 1 grade according to the AIS. The duration of neurological deficits on presentation was not significantly associated with neurological improvement after surgery (p = 0.49, Fisher\u2019s exact test).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>The duration of neurological deficits on presentation should not deter surgeons from operative intervention in cases of spinal coccidioidomycosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.4.spine221210","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T16:15:43Z","timestamp":1685204143000},"page":"419-426","source":"Crossref","is-referenced-by-count":1,"title":["Duration of neurological deficit and outcomes in the surgical treatment of spinal coccidioidomycosis"],"prefix":"10.3171","volume":"39","author":[{"given":"Alexa","family":"Semonche","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin K.","family":"Scheer","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinil N.","family":"Shah","sequence":"additional","affiliation":[{"name":"Radiology and Biomedical Imaging, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee A.","family":"Tan","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean","family":"Chou","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen V.","family":"Mummaneni","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigurd H.","family":"Berven","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery, University of California, San Francisco; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Ames","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedat","family":"Deviren","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery, University of California, San Francisco; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alekos A.","family":"Theologis","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery, University of California, San Francisco; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron J.","family":"Clark","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"J Clin Microbiol","first-page":"26","article-title":"Epidemiologic, clinical, and diagnostic aspects of coccidioidomycosis","volume":"45","author":"Saubolle MA","year":"2007","unstructured":"Saubolle MA, McKellar PP, Sussland D. 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