{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:03:14Z","timestamp":1769835794675,"version":"3.49.0"},"reference-count":31,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Postoperative intracerebral hemorrhages are significant complications following brain stereotactic biopsy. They can derive from anatomical structure (sulci, vessels) damage that is missed during stereotactic trajectory planning. In this study, the authors investigated the ability to detect contact between structures at risk and stereotactic trajectories using signal analysis from MRI obtained during clinical practice, with the aim to propose a visual tool to highlight areas with anatomical structures at risk of damage along the biopsy trajectory.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>The authors retrospectively analyzed actual stereotactic trajectories using intraoperative imaging (intraoperative 2D radiographs in the exploratory data set and intraoperative 3D scans in the confirmatory data set). The MR signal variation along each biopsy trajectory was matched with the patient\u2019s anatomy.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>In the exploratory data set (n = 154 patients), 32 contacts between the actual biopsy trajectory and an anatomical structure at risk were identified along 28 (18.2%) biopsy trajectories, corresponding to 8 preventable intracerebral hemorrhages. Variations of the mean derivative of the MR signal intensity were significantly different between trajectories with and without contact (the pathological threshold of the mean derivative of the MR signal intensity was defined as \u00b1 0.030 arbitrary units; p &lt; 0.0001), with a sensitivity of 89.3% and specificity of 74.6% to detect a contact. In the confirmatory data set (n = 73 patients), the sensitivity and specificity of the 0.030 threshold to detect a contact between the actual stereotactic trajectory and an anatomical structure at risk were 81.3% and 68.4%, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Variations of the mean derivative of the MR signal intensity can be converted into a green\/red color code along the planned biopsy trajectory to highlight anatomical structures at risk, which can help neurosurgeons during the surgical planning of stereotactic procedures.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.5.jns23263","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T15:34:45Z","timestamp":1690644885000},"page":"116-126","source":"Crossref","is-referenced-by-count":2,"title":["Use of MR signal intensity variations to highlight structures at risk along brain biopsy trajectories"],"prefix":"10.3171","volume":"140","author":[{"given":"Marc","family":"Zanello","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"University Paris Cit\u00e9, Paris;"},{"name":"UMR 1266, INSERM, IMA-BRAIN, Institute of Psychiatry and Neurosciences of Paris, France; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9ment","family":"Debacker","sequence":"additional","affiliation":[{"name":"University Paris Cit\u00e9, Paris;"},{"name":"UMR 1266, INSERM, IMA-BRAIN, Institute of Psychiatry and Neurosciences of Paris, France; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Moiraghi","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"University Paris Cit\u00e9, Paris;"},{"name":"UMR 1266, INSERM, IMA-BRAIN, Institute of Psychiatry and Neurosciences of Paris, France; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Roux","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"University Paris Cit\u00e9, Paris;"},{"name":"UMR 1266, INSERM, IMA-BRAIN, Institute of Psychiatry and Neurosciences of Paris, France; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Deboeuf","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"University Paris Cit\u00e9, Paris;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Parraga","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"University Paris Cit\u00e9, Paris;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Dezamis","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"University Paris Cit\u00e9, Paris;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Chr\u00e9tien","sequence":"additional","affiliation":[{"name":"University Paris Cit\u00e9, Paris;"},{"name":"Neuropathology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Oppenheim","sequence":"additional","affiliation":[{"name":"University Paris Cit\u00e9, Paris;"},{"name":"UMR 1266, INSERM, IMA-BRAIN, Institute of Psychiatry and Neurosciences of Paris, France; and"},{"name":"Neuroradiology, GHU Paris\u2013Psychiatrie et Neurosciences, H\u00f4pital Sainte-Anne, Paris;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Pallud","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"University Paris Cit\u00e9, Paris;"},{"name":"UMR 1266, INSERM, IMA-BRAIN, Institute of Psychiatry and Neurosciences of Paris, France; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Clin Neurol Neurosurg","first-page":"101","article-title":"How is stereotactic brain biopsy evolving? 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