{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T12:11:18Z","timestamp":1767183078032},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"\nOBJECTIVE<\/jats:title>\nPatients with low-grade glioma (LGG) in eloquent regions often present with seizures, and findings on detailed neuropsychological testing are often abnormal. This study evaluated the association between cortical excitability, seizures, and cognitive function in patients with LGG.<\/jats:p>\n<\/jats:sec>\n\nMETHODS<\/jats:title>\nLGG patients who underwent transcranial magnetic stimulation (TMS) from January 2021 to December 2022 were studied. Cortical excitability was measured using the resting motor thresholds (RMTs) of the upper and lower extremities. Early postoperative seizures served as the seizure endpoint. Neuropsychological assessment was completed prior to surgery contemporaneous with the TMS studies.<\/jats:p>\n<\/jats:sec>\n\nRESULTS<\/jats:title>\nA total of 31 patients were analyzed for seizure outcome. Median (interquartile range [IQR]) upper-extremity RMT was 39% (34%\u201346%) of maximum stimulator output, and the median (IQR) lower-extremity RMT was 69% (51%\u201379%). Lower-extremity RMT was higher in patients with early postoperative seizures, especially in those with motor region tumors (p = 0.02); however, RMT was not associated with seizures at presentation or long-term seizure control. A total of 26 patients completed neuropsychological assessment. There were significant negative correlations between upper-extremity RMT and psychomotor processing speed (Wechsler Adult Intelligence Scale\u2013Fourth Edition [WAIS-IV] Processing Speed Index r = \u22120.42, p = 0.031; WAIS-IV Coding r = \u22120.41, p = 0.036; WAIS-IV Symbol Search r = \u22120.39, p = 0.048), executive function (Trail Making Test Part B r = \u22120.41, p = 0.036), and hand dexterity (Grooved Pegboard Test r = \u22120.50, p = 0.047).<\/jats:p>\n<\/jats:sec>\n\nCONCLUSIONS<\/jats:title>\nRMT was positively correlated with early postoperative seizure risk and negatively correlated with psychomotor processing speed, executive function, and hand dexterity. These findings support the theory of local and regional resting oscillatory network dysfunction from a glioma-brain network.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.5.jns23747","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T15:05:17Z","timestamp":1688828717000},"page":"18-26","source":"Crossref","is-referenced-by-count":3,"title":["Decoding the clinical effects of low-grade glioma\u2013induced cortical excitability"],"prefix":"10.3171","volume":"140","author":[{"given":"Michael P.","family":"Catalino","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle R.","family":"Noll","sequence":"additional","affiliation":[{"name":"Neuro-oncology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Wefel","sequence":"additional","affiliation":[{"name":"Neuro-oncology,"},{"name":"Radiation Oncology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayley","family":"Michener","sequence":"additional","affiliation":[{"name":"Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Prinsloo","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"},{"name":"Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhakar","family":"Tummala","sequence":"additional","affiliation":[{"name":"Neuro-oncology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujit","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"7580","key":"b1","series-title":"Nature","first-page":"93","article-title":"Brain tumour cells interconnect to a functional and resistant network","volume":"528","author":"Osswald M","year":"2015","unstructured":"Osswald M, Jung E, Sahm F, Brain tumour cells interconnect to a functional and resistant network. Nature. 2015;528(7580):93\u201398."},{"issue":"2","key":"b2","series-title":"Trends Cancer","first-page":"89","article-title":"Neuronal activity in ontogeny and oncology","volume":"3","author":"Venkatesh H","year":"2017","unstructured":"Venkatesh H, Monje M. Neuronal activity in ontogeny and oncology. Trends Cancer. 2017;3(2):89\u2013112."},{"issue":"4","key":"b3","series-title":"Cell","first-page":"803","article-title":"Neuronal activity promotes glioma growth through neuroligin-3 secretion","volume":"161","author":"Venkatesh HS","year":"2015","unstructured":"Venkatesh HS, Johung TB, Caretti V, Neuronal activity promotes glioma growth through neuroligin-3 secretion. Cell. 2015;161(4):803\u2013816."},{"issue":"7775","key":"b4","series-title":"Nature","first-page":"539","article-title":"Electrical and synaptic integration of glioma into neural circuits","volume":"573","author":"Venkatesh HS","year":"2019","unstructured":"Venkatesh HS, Morishita W, Geraghty AC, Electrical and synaptic integration of glioma into neural circuits. Nature. 2019;573(7775):539\u2013545."},{"issue":"7673","key":"b5","series-title":"Nature","first-page":"533","article-title":"Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma","volume":"549","author":"Venkatesh HS","year":"2017","unstructured":"Venkatesh HS, Tam LT, Woo PJ, Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma. Nature. 2017;549(7673):533\u2013537."},{"issue":"7","key":"b6","series-title":"PLoS One","first-page":"e69798","article-title":"Pathological neural attractor dynamics in slowly growing gliomas supports an optimal time frame for white matter plasticity","volume":"8","author":"Szalisznyo K","year":"2013","unstructured":"Szalisznyo K, Silverstein DN, Duffau H, Smits A. Pathological neural attractor dynamics in slowly growing gliomas supports an optimal time frame for white matter plasticity. PLoS One. 2013;8(7):e69798."},{"issue":"50","key":"b7","series-title":"Medicine (Baltimore)","first-page":"e13675","article-title":"IDH mutations but not TERTp mutations are associated with seizures in lower-grade gliomas","volume":"97","author":"Duan WC","year":"2018","unstructured":"Duan WC, Wang L, Li K, IDH mutations but not TERTp mutations are associated with seizures in lower-grade gliomas. Medicine (Baltimore). 2018;97(50):e13675."},{"issue":"19","key":"b8","series-title":"Neurology","first-page":"1805","article-title":"Mutant IDH1 and seizures in patients with glioma","volume":"88","author":"Chen H","year":"2017","unstructured":"Chen H, Judkins J, Thomas C, Mutant IDH1 and seizures in patients with glioma. Neurology. 2017;88(19):1805\u20131813."},{"issue":"9","key":"b9","series-title":"Neuro Oncol","first-page":"1423","article-title":"IDH-mutated gliomas promote epileptogenesis through d-2-hydroxyglutarate-dependent mTOR hyperactivation","volume":"24","author":"Mortazavi A","year":"2022","unstructured":"Mortazavi A, Fayed I, Bachani M, IDH-mutated gliomas promote epileptogenesis through d-2-hydroxyglutarate-dependent mTOR hyperactivation. Neuro Oncol. 2022;24(9):1423\u20131435."},{"issue":"1","key":"b10","series-title":"J Neurooncol","first-page":"77","article-title":"The influence of low-grade glioma on resting state oscillatory brain activity: a magnetoencephalography study","volume":"88","author":"Bosma I","year":"2008","unstructured":"Bosma I, Stam CJ, Douw L, The influence of low-grade glioma on resting state oscillatory brain activity: a magnetoencephalography study. J Neurooncol. 2008;88(1):77\u201385."},{"issue":"12","key":"b11","series-title":"Neuro Oncol","first-page":"1656","article-title":"Neurocognitive function varies by IDH1 genetic mutation status in patients with malignant glioma prior to surgical resection","volume":"18","author":"Wefel JS","year":"2016","unstructured":"Wefel JS, Noll KR, Rao G, Cahill DP. Neurocognitive function varies by IDH1 genetic mutation status in patients with malignant glioma prior to surgical resection. Neuro Oncol. 2016;18(12):1656\u20131663."},{"issue":"1","key":"b12","series-title":"Neurosurgery","first-page":"105","article-title":"Iterative surgical resections of diffuse glioma with awake mapping: how to deal with cortical plasticity and connectomal constraints?","volume":"85","author":"Picart T","year":"2019","unstructured":"Picart T, Herbet G, Moritz-Gasser S, Duffau H. Iterative surgical resections of diffuse glioma with awake mapping: how to deal with cortical plasticity and connectomal constraints? Neurosurgery. 2019;85(1):105\u2013116."},{"issue":"14","key":"b13","series-title":"Cancers (Basel)","first-page":"3327","article-title":"Brain functional connectivity in low- and high-grade gliomas: differences in network dynamics associated with tumor grade and location","volume":"14","author":"Pasquini L","year":"2022","unstructured":"Pasquini L, Jenabi M, Yildirim O, Silveira P, Peck KK, Holodny AI. Brain functional connectivity in low- and high-grade gliomas: differences in network dynamics associated with tumor grade and location. Cancers (Basel). 2022;14(14):3327."},{"issue":"7","key":"b14","series-title":"Acta Neurochir (Wien)","first-page":"1187","article-title":"Protocol for motor and language mapping by navigated TMS in patients and healthy volunteers; workshop report","volume":"159","author":"Krieg SM","year":"2017","unstructured":"Krieg SM, Lioumis P, M\u00e4kel\u00e4 JP, Protocol for motor and language mapping by navigated TMS in patients and healthy volunteers; workshop report. Acta Neurochir (Wien). 2017;159(7):1187\u20131195."},{"issue":"2","key":"b15","series-title":"Report of an IFCN committee. Electroencephalogr Clin Neurophysiol","first-page":"79","article-title":"Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application","volume":"91","author":"Rossini PM","year":"1994","unstructured":"Rossini PM, Barker AT, Berardelli A, Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalogr Clin Neurophysiol. 1994;91(2):79\u201392."},{"issue":"6","key":"b16","series-title":"Clin Neurophysiol","first-page":"1071","article-title":"Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: basic principles and procedures for routine clinical and research application. An updated report from an IFCN Committee","volume":"126","author":"Rossini PM","year":"2015","unstructured":"Rossini PM, Burke D, Chen R, Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: basic principles and procedures for routine clinical and research application. An updated report from an IFCN Committee. Clin Neurophysiol. 2015;126(6):1071\u20131107."},{"issue":"4","key":"b17","series-title":"Top Stroke Rehabil","first-page":"254","article-title":"The corticospinal system and transcranial magnetic stimulation in stroke","volume":"16","author":"Perez MA","year":"2009","unstructured":"Perez MA, Cohen LG. The corticospinal system and transcranial magnetic stimulation in stroke. Top Stroke Rehabil. 2009;16(4):254\u2013269."},{"issue":"4","key":"b18","series-title":"J Neurosurg","first-page":"1227","article-title":"Risk stratification in motor area-related glioma surgery based on navigated transcranial magnetic stimulation data","volume":"126","author":"Rosenstock T","year":"2017","unstructured":"Rosenstock T, Grittner U, Acker G, Risk stratification in motor area-related glioma surgery based on navigated transcranial magnetic stimulation data. J Neurosurg. 2017;126(4):1227\u20131237."},{"issue":"11","key":"b19","series-title":"Stroke","first-page":"2653","article-title":"Interhemispheric asymmetries of motor cortex excitability in the postacute stroke stage: a paired-pulse transcranial magnetic stimulation study","volume":"34","author":"Cicinelli P","year":"2003","unstructured":"Cicinelli P, Pasqualetti P, Zaccagnini M, Traversa R, Oliveri M, Rossini PM. Interhemispheric asymmetries of motor cortex excitability in the postacute stroke stage: a paired-pulse transcranial magnetic stimulation study. Stroke. 2003;34(11):2653\u20132658."},{"issue":"5","key":"b20","series-title":"Neurosurgery","first-page":"1044","article-title":"Neurosurgical outcomes in a modern series of 400 craniotomies for treatment of parenchymal tumors","volume":"42","author":"Sawaya R","year":"1998","unstructured":"Sawaya R, Hammoud M, Schoppa D, Neurosurgical outcomes in a modern series of 400 craniotomies for treatment of parenchymal tumors. Neurosurgery. 1998;42(5):1044\u20131056."},{"issue":"1","key":"b21","series-title":"Hum Brain Mapp","first-page":"1","article-title":"Dissociation of action and object naming: evidence from cortical stimulation mapping","volume":"24","author":"Corina DP","year":"2005","unstructured":"Corina DP, Gibson EK, Martin R, Poliakov A, Brinkley J, Ojemann GA. Dissociation of action and object naming: evidence from cortical stimulation mapping. Hum Brain Mapp. 2005;24(1):1\u201310."},{"key":"b22","article-title":"A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary","author":"Strauss E","year":"2006","unstructured":"Strauss E, Sherman EM, Spreen O. A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary. 3rd ed. Oxford University Press;2006."},{"issue":"2","key":"b23","series-title":"Neurosurgery","first-page":"E332","article-title":"Extent of resection and residual tumor thresholds for postoperative total seizure freedom in epileptic adult patients harboring a supratentorial diffuse low-grade glioma","volume":"85","author":"Still MEH","year":"2019","unstructured":"Still MEH, Roux A, Huberfeld G, Extent of resection and residual tumor thresholds for postoperative total seizure freedom in epileptic adult patients harboring a supratentorial diffuse low-grade glioma. Neurosurgery. 2019;85(2):E332\u2013E340."},{"issue":"1","key":"b24","series-title":"Sci Rep","first-page":"9923","article-title":"Assessment of cortical inhibition depends on inter individual differences in the excitatory neural populations activated by transcranial magnetic stimulation","volume":"12","author":"Cerins A","year":"2022","unstructured":"Cerins A, Corp D, Opie G, Assessment of cortical inhibition depends on inter individual differences in the excitatory neural populations activated by transcranial magnetic stimulation. Sci Rep. 2022;12(1):9923."},{"issue":"2","key":"b25","series-title":"J Neurosurg","first-page":"177","article-title":"Acute postoperative seizures following anterior temporal lobectomy for intractable partial epilepsy","volume":"89","author":"Malla BR","year":"1998","unstructured":"Malla BR, O\u2019Brien TJ, Cascino GD, Acute postoperative seizures following anterior temporal lobectomy for intractable partial epilepsy. J Neurosurg. 1998;89(2):177\u2013182."},{"issue":"12","key":"b26","series-title":"Neuro Oncol","first-page":"1595","article-title":"Lesion momentum as explanation for preoperative neurocognitive function in patients with malignant glioma","volume":"18","author":"Klein M","year":"2016","unstructured":"Klein M. Lesion momentum as explanation for preoperative neurocognitive function in patients with malignant glioma. Neuro Oncol. 2016;18(12):1595\u20131596."},{"issue":"3","key":"b27","series-title":"J Neurooncol","first-page":"565","article-title":"The effect of IDH1 mutation on the structural connectome in malignant astrocytoma","volume":"131","author":"Kesler SR","year":"2017","unstructured":"Kesler SR, Noll K, Cahill DP, Rao G, Wefel JS. The effect of IDH1 mutation on the structural connectome in malignant astrocytoma. 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