{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:35:39Z","timestamp":1793424939223,"version":"4.5.0"},"reference-count":42,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Grade 3 meningioma represents a rare meningioma subtype, for which limited natural history data are available. The objective of this study was to identify demographics and pathologic characteristics, clinical and functional status outcomes, and prognostic factors in an international cohort of grade 3 meningioma patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Clinical and histopathological data were collected for patients treated at 7 sites across North America and Europe between 1991 and 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 103 patients (54% female, median age 65 [IQR 52, 72] years) were included. Sixty-seven (65%) patients had de novo grade 3 lesions, whereas 29 (28%) had malignant transformations of lower-grade meningiomas. All patients underwent initial resection of their tumor. Patients were followed for a median of 46 (IQR 24, 108) months, during which time there were 65 (73%) recurrences and 50 (49%) deaths. The 5-year overall survival (OS) and progression-free survival (PFS) rates were 66% (95% CI 56%\u201377%) and 37% (95% CI 28%\u201348%), respectively. Age \u2265 65 years and male sex were independent predictors of worse OS and PFS in multivariate regression analysis, while postoperative radiotherapy was independently associated with improved OS. Karnofsky Performance Status (KPS) remained stable relative to baseline over 5 years postdiagnosis among participants who were alive at the end of the follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This large multicenter study provides insight into the longitudinal outcomes of grade 3 meningioma, with respect to recurrence, survival, and functional status. This study affirms the survival benefit conferred by radiotherapy in this population and suggests good functional status outcomes for patients surviving to 5 years postoperatively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2023.6.jns23465","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T23:11:51Z","timestamp":1691795511000},"page":"393-403","source":"Crossref","is-referenced-by-count":28,"title":["Grade 3 meningioma survival and recurrence outcomes in an international multicenter cohort"],"prefix":"10.3171","volume":"140","author":[{"given":"Kira","family":"Tosefsky","sequence":"first","affiliation":[{"name":"MD Undergraduate Program, University of British Columbia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander D.","family":"Rebchuk","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, University of British Columbia, Vancouver;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin Z.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, University of Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosef","family":"Ellenbogen","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, University of Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Drexler","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz L.","family":"Ricklefs","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Sauvigny","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Sch\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Germany;"},{"name":"Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf;"},{"name":"Research Institute Children\u2019s Cancer Center Hamburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Cutler","sequence":"additional","affiliation":[{"name":"Chicago Medical School, Rosalind Franklin University, North Chicago, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Lucke-Wold","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Florida, Gainesville, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Mehkri","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Florida, Gainesville, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanju","family":"Lama","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Neurosurgery, University of Calgary;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garnette R.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Division of Neurosurgery, University of Calgary;"},{"name":"Hotchkiss Brain Institute, University of Calgary, Alberta, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Karsy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Hoh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Florida, Gainesville, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Westphal","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelareh","family":"Zadeh","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, University of Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Yip","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Makarenko","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, University of British Columbia, Vancouver;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"12 suppl 2","key":"b1","series-title":"Neuro Oncol","first-page":"iii1","article-title":"CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018","volume":"23","author":"Ostrom QT","year":"2021","unstructured":"Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS. 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