{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T18:22:19Z","timestamp":1783880539462,"version":"3.55.0"},"reference-count":31,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Seizures can be a debilitating manifestation of underlying neoplastic intracranial pathology. Existing literature offers a paucity of scientific consensus regarding risk factors, seizure semiology, operative techniques, and tumor characteristics in pediatric patients with a concurrent diagnosis of primary intracranial neoplasm and seizures. To address the limited evidence in current literature, the authors systematically reviewed published literature on current clinical characteristics and management strategies for patients presenting concurrently with seizures and a newly diagnosed brain lesion, while aiming to synthesize a potential management protocol or set of recommendations for these patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>An initial search revealed 792 papers, of which 196 studies were excluded, leaving 596 studies available for abstract review. After further stratification, 546 studies were eliminated, leaving 50 studies for eligibility assessment. Of the 50 studies, 12 met the criteria for outcome extraction.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The results indicate that patients with a mean age of 9 years with a newly diagnosed brain tumor and presenting symptoms of seizure are likely to present with daily seizures of the complex partial subtype, with the most likely primary epileptogenic and neoplastic foci occurring in the temporal lobe. The most common tumor subtypes were low-grade gliomas, ganglioglioma, dysembryoplastic neuroepithelial tumor, or astrocytoma. With the aim of gross-total resection, 77.54% of patients are likely to achieve seizure freedom.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>This study highlights the demographic, clinical, seizure, tumor, and postoperative outcomes for pediatric patients presenting with a primary brain tumor and concurrent seizures. Further prospective multicenter studies are necessary to understand and compare varying treatment approaches and to develop standardized guidelines for these patients, with the goal of optimizing neuro-oncological and seizure-related outcomes.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.6.peds22440","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T05:16:48Z","timestamp":1691817408000},"page":"576-583","source":"Crossref","is-referenced-by-count":7,"title":["Epileptic versus neuro-oncological focus of management in pediatric patients with concurrent primary brain lesion and seizures: a systematic review"],"prefix":"10.3171","volume":"32","author":[{"given":"Maxwell D.","family":"Gruber","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurosurgery, Nationwide Children\u2019s Hospital, Columbus; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Pindrik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery, Nationwide Children\u2019s Hospital, Columbus; and"},{"name":"Department of Neurosurgery, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Damante","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery, Nationwide Children\u2019s Hospital, Columbus; and"},{"name":"Department of Neurosurgery, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery, Nationwide Children\u2019s Hospital, Columbus; and"},{"name":"Department of Neurosurgery, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar","family":"Shaikhouni","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery, Nationwide Children\u2019s Hospital, Columbus; and"},{"name":"Department of Neurosurgery, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery, Nationwide Children\u2019s Hospital, Columbus; and"},{"name":"Department of Neurosurgery, The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Seizure","first-page":"98","article-title":"Seizures caused by brain tumors in children","volume":"44","author":"S\u00e1nchez Fern\u00e1ndez I","year":"2017","unstructured":"S\u00e1nchez Fern\u00e1ndez I, Loddenkemper T. Seizures caused by brain tumors in children. Seizure. 2017;44:98\u2013107."},{"issue":"10","key":"b2","series-title":"Epilepsia","first-page":"1599","article-title":"Incidence, risk factors, and longitudinal outcome of seizures in long-term survivors of pediatric brain tumors","volume":"56","author":"Ullrich NJ","year":"2015","unstructured":"Ullrich NJ, Pomeroy SL, Kapur K, Manley PE, Goumnerova LC, Loddenkemper T. Incidence, risk factors, and longitudinal outcome of seizures in long-term survivors of pediatric brain tumors. Epilepsia. 2015;56(10):1599\u20131604."},{"issue":"6","key":"b3","series-title":"J Neurosurg Pediatr","first-page":"675","article-title":"Epilepsy surgery related to pediatric brain tumors: Miami Children\u2019s Hospital experience","volume":"16","author":"Fallah A","year":"2015","unstructured":"Fallah A, Weil AG, Sur S,  Epilepsy surgery related to pediatric brain tumors: Miami Children\u2019s Hospital experience. J Neurosurg Pediatr. 2015;16(6):675\u2013680."},{"issue":"4","key":"b4","series-title":"JAMA Neurol","first-page":"464","article-title":"Evidence on use of neuroimaging for surgical treatment of temporal lobe epilepsy: a systematic review","volume":"73","author":"Jones AL","year":"2016","unstructured":"Jones AL, Cascino GD. Evidence on use of neuroimaging for surgical treatment of temporal lobe epilepsy: a systematic review. JAMA Neurol. 2016;73(4):464\u2013470."},{"issue":"1","key":"b5","series-title":"Epilepsia","first-page":"127","article-title":"Epilepsy center characteristics and geographic region influence presurgical testing in the United States","volume":"64","author":"Ahrens SM","year":"2023","unstructured":"Ahrens SM, Arredondo KH, Bagi\u0107 AI,  Epilepsy center characteristics and geographic region influence presurgical testing in the United States. 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