{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T02:49:49Z","timestamp":1769568589560,"version":"3.49.0"},"reference-count":17,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Radiofrequency thalamotomy (RF-T) is an established treatment for refractory tremor. It is unclear whether connectivity-guided targeting strategies could further augment outcomes. The aim of this study was to evaluate the efficacy and safety of MRI connectivity\u2013guided RF-T in severe tremor.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Twenty-one consecutive patients with severe tremor (14 with essential tremor [ET], 7 with Parkinson\u2019s disease [PD]) underwent unilateral RF-T at a single institution between 2017 and 2020. Connectivity-derived thalamic segmentation was used to guide targeting. Changes in the Fahn-Tolosa-Marin Rating Scale (FTMRS) were recorded in treated and nontreated hands as well as procedure-related side effects.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Twenty-three thalamotomies were performed (with 2 patients receiving a repeated intervention). The mean postoperative assessment time point was 14.1 months. Treated-hand tremor scores improved by 63.8%, whereas nontreated-hand scores deteriorated by 10.1% (p &lt; 0.01). Total FTMRS scores were significantly better at follow-up compared with baseline (mean 34.7 vs 51.7, p = 0.016). Baseline treated-hand tremor severity (rho = 0.786, p &lt; 0.01) and total FTMRS score (rho = 0.64, p &lt; 0.01) best correlated with tremor improvement. The most reported side effect was mild gait ataxia (n = 11 patients).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>RF-T guided by connectivity-derived segmentation is a safe and effective option for severe tremor in both PD and ET.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.7.jns222744","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T01:23:36Z","timestamp":1697246616000},"page":"1148-1154","source":"Crossref","is-referenced-by-count":5,"title":["Clinical outcomes after MRI connectivity\u2013guided radiofrequency thalamotomy for tremor"],"prefix":"10.3171","volume":"140","author":[{"given":"Thomas","family":"Wirth","sequence":"first","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery, UCLH-UCL Queen Square Institute of Neurology, London, United Kingdom;"},{"name":"Neurology Department, Strasbourg University Hospital, Strasbourg, France;"},{"name":"Institute of Genetics and Molecular and Cellular Biology, University of Strasbourg, Illkirch, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taco","family":"Goedemans","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery, UCLH-UCL Queen Square Institute of Neurology, London, United Kingdom;"},{"name":"Department of Neurosurgery, Amsterdam UMC, University of Amsterdam, Neurosurgical Center Amsterdam, The Netherlands;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Rajabian","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery, UCLH-UCL Queen Square Institute of Neurology, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viswas","family":"Dayal","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery, UCLH-UCL Queen Square Institute of Neurology, London, United Kingdom;"},{"name":"Neurology Department, Auckland City Hospital, Auckland, New Zealand;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem","family":"Abuhusain","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery, UCLH-UCL Queen Square Institute of Neurology, London, United Kingdom;"},{"name":"Neurosurgery Department, Royal Hallamshire Hospital, Sheffield, United Kingdom; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirosen","family":"Vijiaratnam","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery, UCLH-UCL Queen Square Institute of Neurology, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilan","family":"Athauda","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery, UCLH-UCL Queen Square Institute of Neurology, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwan","family":"Hariz","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery, UCLH-UCL Queen Square Institute of Neurology, London, United Kingdom;"},{"name":"Department of Clinical Science, Neuroscience, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Foltynie","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery, UCLH-UCL Queen Square Institute of Neurology, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Limousin","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery, UCLH-UCL Queen Square Institute of Neurology, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harith","family":"Akram","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery, UCLH-UCL Queen Square Institute of Neurology, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludvic","family":"Zrinzo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences, Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery, UCLH-UCL Queen Square Institute of Neurology, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"Mov Disord","first-page":"75","article-title":"Consensus statement on the classification of tremors. 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