{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T01:53:08Z","timestamp":1772243588641,"version":"3.50.1"},"reference-count":35,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The effect of subthalamic nucleus (STN) deep brain stimulation (DBS) on urinary dysfunction and constipation in Parkinson\u2019s disease (PD) is variable. This study aimed to identify potential surgical and nonsurgical variables predictive of these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors used the Movement Disorder Society\u2013Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS) Part I to assess urinary dysfunction (item 10) and constipation (item 11) preoperatively and at 6\u201312 months postoperatively. A multiple linear regression model was used to investigate the impact of global cerebral atrophy (GCA) and active electrode contact location on the urinary dysfunction and constipation follow-up scores, controlling for age, disease duration, baseline score, motor improvement, and levodopa-equivalent dose changes. An electric field model was applied to localize the maximal-effect sites for constipation and urinary dysfunction compared with those for motor improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Among 74 patients, 23 improved, 28 deteriorated, and 23 remained unchanged for urinary dysfunction; 25 improved, 15 deteriorated, and 34 remained unchanged for constipation. GCA score and age significantly predicted urinary dysfunction follow-up score (R\n                      <jats:sup>2<\/jats:sup>\n                      = 0.36, p &lt; 0.001). Increased GCA and age were independently associated with worsening urinary symptoms. Disease duration, baseline constipation score, and anterior active electrode contacts in both hemispheres were significant predictors of constipation follow-up score (R\n                      <jats:sup>2<\/jats:sup>\n                      = 0.31, p &lt; 0.001). Higher baseline constipation score and disease duration were associated with worsening constipation; anterior active contact location was associated with improvement in constipation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Anterior active contact location was associated with improvement in constipation in PD patients after STN DBS. PD patients with greater GCA scores before surgery were more likely to experience urinary deterioration after DBS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2023.7.jns23837","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T23:49:28Z","timestamp":1695426568000},"page":"657-664","source":"Crossref","is-referenced-by-count":5,"title":["Impact of subthalamic nucleus stimulation on urinary dysfunction and constipation in Parkinson\u2019s disease"],"prefix":"10.3171","volume":"140","author":[{"given":"Asra","family":"Askari","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon J.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Biomedical Engineering, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan L. W.","family":"Lam","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara J.","family":"Wyant","sequence":"additional","affiliation":[{"name":"Neurology, University of Michigan, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelvin L.","family":"Chou","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"},{"name":"Neurology, University of Michigan, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parag G.","family":"Patil","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"},{"name":"Biomedical Engineering, and"},{"name":"Neurology, University of Michigan, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"4","key":"b1","series-title":"Mov Disord Clin Pract (Hoboken)","first-page":"373","article-title":"Clinical impact of deep brain stimulation on the autonomic system in patients with Parkinson\u2019s disease","volume":"7","author":"Bellini G","year":"2020","unstructured":"Bellini G, Best LA, Brechany U, Mills R, Pavese N. 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