{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:40:17Z","timestamp":1793860817426,"version":"4.6.1"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Evidence on timing for mobilization after chronic subdural hematoma (cSDH) surgery is heterogeneous, and practices differ considerably among neurosurgical centers. The Impact of an Early Out-of-Bed Paradigm in Postoperative Outcomes of Chronic Subdural Hematomas: GET-UP Randomized Prospective Trial (GET-UP Trial) is a randomized clinical trial comparing a postoperative early mobilization protocol to bed rest. Previously reported results at clinical discharge and 1 month after surgery indicated a decreased risk of medical complications in the early mobilization group. Herein, the authors report outcomes at the 1-year follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The GET-UP Trial is a prospective, randomized, unicentric, open-label study with an intention-to-treat primary analysis designed to evaluate the impact of an early mobilization protocol after burr hole craniostomy for cSDH on the occurrence of medical complications and functional outcomes. Between January 2019 and August 2021, a total of 208 patients were recruited and randomized to either an early mobilization group, in which patients began elevation of the head of the bed within the first 12 hours after surgery, or to a bed rest group, in which patients remained recumbent for 48 hours. Outcomes assessed at the 1-year follow-up included functional status as measured by the Glasgow Outcome Scale\u2013Extended (GOSE) and repeat surgery for hematoma recurrence (surgical recurrence).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 203 patients completed 1 year of follow-up: 101 in the bed rest group and 102 in the early mobilization group. No significant baseline pre-randomization clinical differences were observed between the two management groups. At 1 year after surgery, a favorable functional outcome, defined as a GOSE score \u2265 5, was observed in 59 patients (58.4%) in the bed rest group and 78 (76.5%) in the early mobilization group (p = 0.006). Death occurred in 25 patients (24.8%) in the bed rest group and 16 (15.7%) in the early mobilization group (p = 0.108). Surgical recurrence was noted in 6 patients (5.9%) in the bed rest group and 7 (6.9%) in the early mobilization group (p = 0.788). Multivariate analysis showed an independent association between early mobilization and an increase in favorable functional outcomes (OR 2.006, 95% CI 1.076\u20133.739, p = 0.028).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The GET-UP Trial is the first randomized clinical trial assessing the impact of mobilization strategies on medical complications after burr hole craniostomy for cSDH. Regarding functional results 1 year after surgery, early mobilization was associated with an improvement in functional outcomes without an increase in surgical recurrence. These findings support the preference for an early mobilization protocol in cSDH patients over mandatory bed rest strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2023.8.jns231509","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T20:28:32Z","timestamp":1699648112000},"page":"1434-1441","source":"Crossref","is-referenced-by-count":18,"title":["GET-UP Trial 1-year results: long-term impact of an early mobilization protocol on functional performance after surgery for chronic subdural hematoma"],"prefix":"10.3171","volume":"140","author":[{"given":"Vasco","family":"Pinto","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University Hospital Center of Santo Ant\u00f3nio, Porto;"},{"name":"Department of Anatomy, UMIB\u2013Unit for Multidisciplinary Research in Biomedicine, ICBAS\u2013School of Medicine and Biomedical Sciences, University of Porto; and"},{"name":"ITR\u2013Laboratory for Integrative and 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Stroke. 2017;48(3):740\u2013746."},{"issue":"2","key":"b24","series-title":"NeuroRehabilitation","first-page":"303","article-title":"Functional mobility effects of progressive early mobilization protocol on people with moderate-to-severe traumatic brain injury: a pre-post intervention study","volume":"51","author":"Yen HC","year":"2022","unstructured":"Yen HC, Han YY, Hsiao WL,  Functional mobility effects of progressive early mobilization protocol on people with moderate-to-severe traumatic brain injury: a pre-post intervention study. NeuroRehabilitation. 2022;51(2):303\u2013313."},{"issue":"2","key":"b25","series-title":"J Comp Eff Res","first-page":"121","article-title":"Early mobilization in enhanced recovery after surgery pathways: current evidence and recent advancements","volume":"11","author":"Tazreean R","year":"2022","unstructured":"Tazreean R, Nelson G, Twomey R. Early mobilization in enhanced recovery after surgery pathways: current evidence and recent advancements. J Comp Eff Res. 2022;11(2):121\u2013129."},{"key":"b26","series-title":"World Neurosurg","first-page":"402","article-title":"Pathophysiology and nonsurgical treatment of chronic subdural hematoma: from past to present to future","volume":"116","author":"Holl DC","year":"2018","unstructured":"Holl DC, Volovici V, Dirven CMF,  Pathophysiology and nonsurgical treatment of chronic subdural hematoma: from past to present to future. World Neurosurg. 2018;116:402\u2013411.e2."},{"issue":"4","key":"b27","series-title":"Neurosurgery","first-page":"720","article-title":"Study protocol on defining core outcomes and data elements in chronic subdural haematoma","volume":"89","author":"Holl DC","year":"2021","unstructured":"Holl DC, Chari A, Iorio-Morin C,  Study protocol on defining core outcomes and data elements in chronic subdural haematoma. 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