{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:49:06Z","timestamp":1792068546590,"version":"4.4.0"},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Loeys-Dietz syndrome (LDS) is a heritable aortopathy associated with craniofacial abnormalities and dilatation and dissection of the aorta and its branches, as well as increased risk for intracranial aneurysms (ICAs). Given the rarity of the disease, the authors aimed to better define the natural history and role for the treatment for ICAs in these patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>The medical records of 83 patients with LDS were retrospectively reviewed to obtain clinical and genetic history and vascular imaging of the aorta, aortic branches, and intracranial vessels. Serial radiology reports and cervical and intracranial vascular images were reviewed to determine presence, location, and size of ICAs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>In total, 55 patients (66.3%) had at least two screening intracranial vascular examinations, and 19 (22.9%) had at least 1 ICA detected. Aneurysms were typically small (mean \u00b1 SD 3.2 \u00b1 1.8 mm). ICAs were most often located in the cavernous carotid, followed by the ophthalmic and anterior cerebral artery vessels. The rate of ICA growth was 0.43 \u00b1 0.53 mm\/year, similar to that of the general population. Three patients underwent intervention for an ICA, with 1 procedure complicated by stroke and resulting in transient hemiparesis. Several illustrative cases detail the authors\u2019 experience with ICA growth, de novo aneurysm formation, and ICA intervention in this rare patient population.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>ICAs in patients with LDS are common, are frequently small, and have a growth rate similar to that of unruptured ICAs in the general population. More aggressive or earlier intervention for asymptomatic ICAs identified in LDS patients compared with the general population is likely unwarranted based on the authors\u2019 experience at their institution.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.8.jns23733","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T01:28:08Z","timestamp":1699666088000},"page":"1381-1388","source":"Crossref","is-referenced-by-count":6,"title":["Natural history and growth rate of intracranial aneurysms in Loeys-Dietz syndrome: implications for treatment"],"prefix":"10.3171","volume":"140","author":[{"given":"Anna L.","family":"Huguenard","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Washington University in St. Louis, Missouri; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle W.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Washington University in St. Louis, Missouri; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua W.","family":"Osbun","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Washington University in St. Louis, Missouri; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph G.","family":"Dacey","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Washington University in St. Louis, Missouri; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan C.","family":"Braverman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cardiovascular Division, Washington University in St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"3","key":"b1","series-title":"Nat Genet","first-page":"275","article-title":"A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2","volume":"37","author":"Loeys BL","year":"2005","unstructured":"Loeys BL, Chen J, Neptune ER,  A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. 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