{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:46:30Z","timestamp":1785444390361,"version":"3.56.0"},"reference-count":29,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Headache relief after anterior cervical spine surgery has been reported. No study, however, has followed patients out to 10 years to assess the durability of headache improvement. The authors analyzed a group of patients with a 10-year follow-up after one- or two-level cervical disc arthroplasty (CDA) from an FDA investigational device exemption (IDE) study.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>The authors performed a post hoc analysis of 189 patients treated with CDA from the 9 highest enrolling sites in a prospective multicenter randomized US FDA IDE clinical trial. Patients had one- or two-level CDA at contiguous levels from C3 to C7 using the Mobi-C device. The authors evaluated headache scores from the headache section of the Neck Disability Index (NDI), along with associated demographic variables (age, sex, race, ethnicity, and BMI). Preoperative and 10-year postoperative headache scores were analyzed. Primary analysis was conducted via the Wilcoxon rank-sum test, followed by univariate and multivariable logistic regression.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>After accounting for age, BMI, race, ethnicity, and sex, there was sustained headache improvement 10 years after CDA (p = 0.04). Preoperatively, the median NDI score was 3.00 (IQR 1.00\u20134.00) and after 10 years it was 1.00 (IQR 0.00\u20132.00), with a decrease in the NDI score by 1.00 point (95% CI 0.00\u20132.00, p = 0.04). For one-level CDA, the median NDI score was 3.00 (IQR 1.00\u20134.00) preoperatively but 1.00 (IQR 0.00\u20132.00) at 10 years, with an estimated reduction in the NDI score of 1 point (95% CI 1.00\u20132.00, p &lt; 0.0001). For two-level CDA, the median NDI score was 3.00 (IQR 1.75\u20134.00) preoperatively and 1.00 (IQR 0.00\u20132.00) at 10 years, with an estimated reduction in the NDI score of 1 point (95% CI 1.00\u20132.00, p &lt; 0.0001).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Headache relief provided by cervical CDA, for symptomatic C3\u20137 cervical spondylosis, was sustained even 10 years after surgery. There was no difference in headache improvement between the one- and two-level CDA groups, or among BMI, sex, race, and ethnicity strata.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.8.spine23524","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T01:59:11Z","timestamp":1696643951000},"page":"54-61","source":"Crossref","is-referenced-by-count":4,"title":["Headache relief 10 years after cervical disc arthroplasty: multicenter randomized clinical trial post hoc analysis"],"prefix":"10.3171","volume":"40","author":[{"given":"James","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of California, Davis, Sacramento, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Desert Regional Medical Center, Palm Springs, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Ghaffari-Rafi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California, Davis, Sacramento, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California, Davis, Sacramento, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California, Davis, Sacramento, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"Sci Rep","first-page":"5389","article-title":"Prevalence of spine degeneration diagnosis by type, age, gender, and obesity using Medicare data","volume":"11","author":"Parenteau CS","year":"2021","unstructured":"Parenteau CS, Lau EC, Campbell IC, Courtney A. Prevalence of spine degeneration diagnosis by type, age, gender, and obesity using Medicare data. Sci Rep. 2021;11(1):5389."},{"key":"b2","series-title":"StatPearls","article-title":"Cervical degenerative disc disease","author":"Fakhoury J","year":"2022","unstructured":"Fakhoury J, Dowling TJ. Cervical degenerative disc disease. In: StatPearls. StatPearls Publishing; 2022. StatPearls Publishing; 2022."},{"issue":"3","key":"b3","series-title":"Neurosurgery","first-page":"497","article-title":"Ten-year outcomes of 1- and 2-level cervical disc arthroplasty from the Mobi-C investigational device exemption clinical trial","volume":"88","author":"Kim K","year":"2021","unstructured":"Kim K, Hoffman G, Bae H,  Ten-year outcomes of 1- and 2-level cervical disc arthroplasty from the Mobi-C investigational device exemption clinical trial. 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