{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:57:49Z","timestamp":1793800669796,"version":"4.6.1"},"reference-count":45,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>The modern management of patients with Koos grade IV vestibular schwannomas (VSs) aims at functional preservation and long-term tumor control. Gross-total resection (GTR) leads to optimal tumor control but frequently also results in permanent facial nerve (FN) palsy. Subtotal resection (STR) or near-total resection (NTR) followed by a wait-and-scan protocol and second-line radiation therapy (RT) in case of progressive residuals yields excellent tumor control rates with less permanent morbidity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>The authors present the results of their prospective cohort of Koos grade IV VS patients who underwent less-than-total resection followed by a wait-and-scan protocol between January 2009 and December 2019 and discuss the latest evidence on this controversial subject. The cohort was followed up with annual clinical and volumetric outcome analyses after standardized MRI.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Forty-eight patients were included in the analysis. The mean extent of resection was 87% (median 91%, range 45%\u2013100%), best fitting into the definition of STR rather than NTR. In 2 cases, the proximal portion of the FN at the brainstem could not be reliably identified and monitored during the initial operation, and a second-stage resection was necessary. At 4.4 years after surgery, 81% (39\/48) of the tumor residuals regressed or were stable in size. The percentage of regressive tumor residuals increased over time. Nineteen percent (9\/48) of the tumor residuals displayed volumetric progression within a mean time of 35 months (median 36 months, range 14\u201372 months), resulting in a Kaplan-Meier estimate for progression-free survival of 79% after 4 years; higher postoperative volume showed a linear correlation with higher volumetric progression (factor 1.96, 95% CI 1.67\u20132.30; p &lt; 0.001). Thirty-four of the 48 (71%) patients continue to undergo a wait-and-scan protocol. Second-line RT was performed in 14 patients (29%) within a mean time of 25 months (median 23 months, range 5\u201354 months), 12 (86%) of whom responded with post-RT pseudoprogression, resulting in an overall tumor control rate of 96%. At the 4.4-year follow-up from the initial resection, 92% of the patients had a good facial outcome (House-Brackmann [HB] grade I or II), 6% had a fair facial outcome (HB grade III), and 2% had a poor facial outcome (HB grades IV\u2013VI). So far, there has been no need for salvage surgery after RT.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>STR followed by observation and second-line RT in cases of progression leads to good facial outcome and an excellent tumor control rate in the longer term.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2023.9.jns231316","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T01:20:17Z","timestamp":1701480017000},"page":"1591-1604","source":"Crossref","is-referenced-by-count":8,"title":["Long-term tumor control in Koos grade IV vestibular schwannomas without the need for gross-total resection"],"prefix":"10.3171","volume":"140","author":[{"given":"Michel","family":"Roethlisberger","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Faculty of Medicine, University of Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giusi","family":"Moffa","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Computer Science, University of Basel, Switzerland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Rychen","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attill","family":"Saemann","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Straumann","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Taub","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Zumofen","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Maimonides Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Neddersen","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Westermann","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bodmer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Basel, Switzerland;"},{"name":"Oto-Rhino-Laryngology, University Hospital Basel, University of Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Mariani","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"},{"name":"Faculty of Medicine, University of Basel, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"4","key":"b1","series-title":"Neurosurgery","first-page":"684","article-title":"Management of 1000 vestibular schwannomas (acoustic neuromas): the facial nerve\u2014preservation and restitution of function","volume":"40","author":"Samii M","year":"1997","unstructured":"Samii M, Matthies C. 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