{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:33:58Z","timestamp":1790922838927,"version":"4.1.0"},"reference-count":39,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>The medial forebrain bundle (MFB) is a novel promising deep brain stimulation (DBS) target in severe affective disorders that courses through the subthalamic region according to tractography studies. Its potential therapeutic role arose in connection with the development of hypomania during stimulation of the subthalamic nucleus (STN) in Parkinson\u2019s disease, offering an alternative explanation for the occurrence of this side effect. However, until now its course exclusively described by tractography had not yet been confirmed by any anatomical method. The aim of this study was to fill this gap as well as to provide a detailed description of the fiber tracts surrounding the STN to facilitate a better understanding of the background of side effects occurring during STN DBS.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Ten human cadaveric brains (20 hemispheres) and 100 healthy subjects (200 hemispheres) from the S500 Release of the Human Connectome Project were involved in this study. Nineteen hemispheres were dissected according to Klingler\u2019s method. One additional hemisphere was prepared for histological examinations to validate the macroscopical results and stained with neurofibril silver impregnation according to Krutsay. The authors also aimed to reconstruct the MFB using tractography and correlated the results with their dissections and histological findings.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The white matter connections coursing through the subthalamic region were successfully dissected. The ansa lenticularis, lenticular fasciculus, thalamic fasciculus, ipsi- and contralateral cerebellar fibers, and medial lemniscus were revealed as closely related fiber tracts to the STN. However, the existence of a distinct fiber bundle corresponding to the MFB described by tractography could not be identified. Using tractography, the authors showed that the depiction of the streamlines representing the MFB was also strongly dependent on the threshold parameters.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>According to this study\u2019s findings, the streamlines of the MFB described by tractography arise from the limitations of the diffusion-weighted MRI fiber tracking method and actually correspond to subthalamic fiber bundles, especially the ansa lenticularis and lenticular fasciculus, which erroneously continue in the anterior limb of the internal capsule, toward the prefrontal cortex.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.1.jns232066","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T01:25:32Z","timestamp":1710552332000},"page":"570-580","source":"Crossref","is-referenced-by-count":4,"title":["Topographical anatomy of the subthalamic region with special interest in the human medial forebrain bundle"],"prefix":"10.3171","volume":"141","author":[{"given":"Cintia","family":"Meszaros","sequence":"first","affiliation":[{"name":"Department of Anatomy, Semmelweis University, Budapest, Hungary;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kurucz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Katharinenhospital, Klinikum Stuttgart, Germany;"},{"name":"Department of Neurosurgery, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Baksa","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Semmelweis University, Budapest, Hungary;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Alpar","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Semmelweis University, Budapest, Hungary;"},{"name":"MTA-SE NAP Research Group of Experimental Neuroanatomy and Developmental Biology, Hungarian Academy of Sciences, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Ganslandt","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Katharinenhospital, Klinikum Stuttgart, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Brandner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Barany","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"4","key":"b1","series-title":"Neurosurg Rev","first-page":"2593","article-title":"Novel targets in deep brain stimulation for movement disorders","volume":"45","author":"Baumgartner AJ","year":"2022","unstructured":"Baumgartner AJ, Thompson JA, Kern DS, Ojemann SG. Novel targets in deep brain stimulation for movement disorders. Neurosurg Rev. 2022;45(4):2593\u20132613."},{"key":"b2","series-title":"J Neurol Sci","first-page":"120253","article-title":"Deep brain stimulation for psychiatric disorders and behavioral\/cognitive-related indications: review of the literature and implications for treatment","volume":"437","author":"Mahoney JJ III","year":"2022","unstructured":"Mahoney JJ III, Koch-Gallup N, Scarisbrick DM, Berry JH, Rezai AR. Deep brain stimulation for psychiatric disorders and behavioral\/cognitive-related indications: review of the literature and implications for treatment. J Neurol Sci. 2022;437:120253."},{"key":"b3","series-title":"Neuroimage Clin","first-page":"770","article-title":"The anatomy of the human medial forebrain bundle: ventral tegmental area connections to reward-associated subcortical and frontal lobe regions","volume":"18","author":"Coenen VA","year":"2018","unstructured":"Coenen VA, Schumacher LV, Kaller C,  The anatomy of the human medial forebrain bundle: ventral tegmental area connections to reward-associated subcortical and frontal lobe regions. Neuroimage Clin. 2018;18:770\u2013783."},{"issue":"6","key":"b4","series-title":"Neurosurgery","first-page":"1106","article-title":"Medial forebrain bundle stimulation as a pathophysiological mechanism for hypomania in subthalamic nucleus deep brain stimulation for Parkinson\u2019s disease","volume":"64","author":"Coenen VA","year":"2009","unstructured":"Coenen VA, Honey CR, Hurwitz T,  Medial forebrain bundle stimulation as a pathophysiological mechanism for hypomania in subthalamic nucleus deep brain stimulation for Parkinson\u2019s disease. Neurosurgery. 2009;64(6):1106\u20131115."},{"issue":"1","key":"b5","series-title":"J Neuropsychiatry Clin Neurosci","first-page":"102","article-title":"Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson\u2019s disease: a review of the literature","volume":"24","author":"Chopra A","year":"2012","unstructured":"Chopra A, Tye SJ, Lee KH,  Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson\u2019s disease: a review of the literature. J Neuropsychiatry Clin Neurosci. 2012;24(1):102\u2013110."},{"key":"b6","article-title":"The Human Central Nervous System: A Synopsis and Atlas","author":"Nieuwenhuys R","year":"2007","unstructured":"Nieuwenhuys R, Voogd J, van Huijzen C. The Human Central Nervous System: A Synopsis and Atlas. Springer Science & Business Media; 2007."},{"issue":"2","key":"b7","series-title":"J Neuropsychiatry Clin Neurosci","first-page":"223","article-title":"Human medial forebrain bundle (MFB) and anterior thalamic radiation (ATR): imaging of two major subcortical pathways and the dynamic balance of opposite affects in understanding depression","volume":"24","author":"Coenen VA","year":"2012","unstructured":"Coenen VA, Panksepp J, Hurwitz TA, Urbach H, M\u00e4dler B. Human medial forebrain bundle (MFB) and anterior thalamic radiation (ATR): imaging of two major subcortical pathways and the dynamic balance of opposite affects in understanding depression. J Neuropsychiatry Clin Neurosci. 2012;24(2):223\u2013236."},{"issue":"9","key":"b8","series-title":"AJNR Am J Neuroradiol","first-page":"1558","article-title":"Neuroimaging advances in deep brain stimulation: review of indications, anatomy, and brain connectomics","volume":"41","author":"Middlebrooks EH","year":"2020","unstructured":"Middlebrooks EH, Domingo RA, Vivas-Buitrago T,  Neuroimaging advances in deep brain stimulation: review of indications, anatomy, and brain connectomics. AJNR Am J Neuroradiol. 2020;41(9):1558\u20131568."},{"issue":"10","key":"b9","series-title":"Biol Psychiatry","first-page":"667","article-title":"Four deep brain stimulation targets for obsessive-compulsive disorder: are they different?","volume":"90","author":"Haber SN","year":"2021","unstructured":"Haber SN, Yendiki A, Jbabdi S. Four deep brain stimulation targets for obsessive-compulsive disorder: are they different? Biol Psychiatry. 2021;90(10):667\u2013677."},{"issue":"1","key":"b10","series-title":"Neuropsychopharmacology","first-page":"20","article-title":"Prefrontal connectomics: from anatomy to human imaging","volume":"47","author":"Haber SN","year":"2022","unstructured":"Haber SN, Liu H, Seidlitz J, Bullmore E. Prefrontal connectomics: from anatomy to human imaging. Neuropsychopharmacology. 2022;47(1):20\u201340."},{"issue":"11","key":"b11","series-title":"J Neurosci","first-page":"4804","article-title":"The organization of prefrontal-subthalamic inputs in primates provides an anatomical substrate for both functional specificity and integration: implications for basal ganglia models and deep brain stimulation","volume":"33","author":"Haynes WIA","year":"2013","unstructured":"Haynes WIA, Haber SN. The organization of prefrontal-subthalamic inputs in primates provides an anatomical substrate for both functional specificity and integration: implications for basal ganglia models and deep brain stimulation. J Neurosci. 2013;33(11):4804\u20134814."},{"issue":"2","key":"b12","series-title":"Brain Stimul","first-page":"670","article-title":"Tomographic tract tracing and data driven approaches to unravel complex 3D fiber anatomy of DBS relevant prefrontal projections to the diencephalic-mesencephalic junction in the marmoset","volume":"16","author":"Coenen VA","year":"2023","unstructured":"Coenen VA, Watakabe A, Skibbe H,  Tomographic tract tracing and data driven approaches to unravel complex 3D fiber anatomy of DBS relevant prefrontal projections to the diencephalic-mesencephalic junction in the marmoset. Brain Stimul. 2023;16(2):670\u2013681."},{"issue":"7","key":"b13","series-title":"Neuropsychopharmacology","first-page":"1224","article-title":"Superolateral medial forebrain bundle deep brain stimulation in major depression: a gateway trial","volume":"44","author":"Coenen VA","year":"2019","unstructured":"Coenen VA, Bewernick BH, Kayser S,  Superolateral medial forebrain bundle deep brain stimulation in major depression: a gateway trial. Neuropsychopharmacology. 2019;44(7):1224\u20131232."},{"issue":"1","key":"b14","series-title":"Mol Psychiatry","first-page":"574","article-title":"Deep brain stimulation of the \"medial forebrain bundle\": a strategy to modulate the reward system and manage treatment-resistant depression","volume":"27","author":"Fenoy AJ","year":"2022","unstructured":"Fenoy AJ, Quevedo J, Soares JC. Deep brain stimulation of the \"medial forebrain bundle\": a strategy to modulate the reward system and manage treatment-resistant depression. Mol Psychiatry. 2022;27(1):574\u2013592."},{"key":"b15","article-title":"Human Connectome Project","unstructured":"Human Connectome Project. Accessed January 19, 2024. https:\/\/www.humanconnectome.org\/"},{"key":"b16","series-title":"Schweiz Arch Neurol Psychiatr","first-page":"247","article-title":"Erleichterung der makroskopischen Pr\u00e4paration des Gehirns durch den Gefrierprozess","volume":"36","author":"Klingler J","year":"1935","unstructured":"Klingler J. Erleichterung der makroskopischen Pr\u00e4paration des Gehirns durch den Gefrierprozess. Schweiz Arch Neurol Psychiatr. 1935;36:247\u2013256."},{"issue":"1","key":"b17","series-title":"Anat Anz","first-page":"77","article-title":"Silver impregnation of neurofibrils in paraffin sections. Article in German","volume":"164","author":"Krutsay M","year":"1987","unstructured":"Krutsay M. Silver impregnation of neurofibrils in paraffin sections. Article in German. Anat Anz. 1987;164(1):77\u201380."},{"key":"b18","series-title":"Neuroimage","first-page":"116137","article-title":"Mrtrix3: a fast, flexible and open software framework for medical image processing and visualisation","volume":"202","author":"Tournier JD","year":"2019","unstructured":"Tournier JD, Smith R, Raffelt D,  Mrtrix3: a fast, flexible and open software framework for medical image processing and visualisation. Neuroimage. 2019;202:116137."},{"key":"b19","series-title":"Proc Intl Soc Mag Reson Med","first-page":"1670","article-title":"Improved probabilistic streamlines tractography by 2nd order integration over fibre orientation distributions","volume":"18","author":"Tournier JD","year":"2010","unstructured":"Tournier JD, Calamante F, Connelly A. Improved probabilistic streamlines tractography by 2nd order integration over fibre orientation distributions. Proc Intl Soc Mag Reson Med. 2010;18:1670. Accessed January 19, 2024. https:\/\/archive.ismrm.org\/2010\/1670.html"},{"key":"b20","series-title":"Neuroimage","first-page":"411","article-title":"Multi-tissue constrained spherical deconvolution for improved analysis of multi-shell diffusion MRI data","volume":"103","author":"Jeurissen B","year":"2014","unstructured":"Jeurissen B, Tournier JD, Dhollander T, Connelly A, Sijbers J. Multi-tissue constrained spherical deconvolution for improved analysis of multi-shell diffusion MRI data. Neuroimage. 2014;103:411\u2013426."},{"key":"b21","series-title":"Proc Intl Soc Mag Reson Med","first-page":"555","article-title":"Improved white matter response function estimation for 3-tissue constrained spherical deconvolution","volume":"27","author":"Dhollander T","year":"2019","unstructured":"Dhollander T, Mito R, Raffelt D, Connelly A. Improved white matter response function estimation for 3-tissue constrained spherical deconvolution. Proc Intl Soc Mag Reson Med. 2019;27:555. Accessed January 19, 2024. https:\/\/archive.ismrm.org\/2019\/0555.html"},{"key":"b22","series-title":"Neuroimage Clin","first-page":"102165","article-title":"Tractographic description of major subcortical projection pathways passing the anterior limb of the internal capsule. Corticopetal organization of networks relevant for psychiatric disorders","volume":"25","author":"Coenen VA","year":"2020","unstructured":"Coenen VA, Schlaepfer TE, Sajonz B,  Tractographic description of major subcortical projection pathways passing the anterior limb of the internal capsule. Corticopetal organization of networks relevant for psychiatric disorders. Neuroimage Clin. 2020;25:102165."},{"issue":"3","key":"b23","series-title":"Arch Psychiatr Nervenkr","first-page":"393","article-title":"Untersuchungen \u00fcber die Haubenregion und ihre oberen Verkn\u00fcpfungen im Gehirne des Menschen und einiger S\u00e4ugethiere, mit Beitr\u00e4gen zu den Methoden der Gehirnuntersuchung","volume":"7","author":"Forel A","year":"1877","unstructured":"Forel A. Untersuchungen \u00fcber die Haubenregion und ihre oberen Verkn\u00fcpfungen im Gehirne des Menschen und einiger S\u00e4ugethiere, mit Beitr\u00e4gen zu den Methoden der Gehirnuntersuchung. Arch Psychiatr Nervenkr. 1877;7(3):393\u2013495."},{"key":"b24","article-title":"Anatomie Des Centres Nerveux","author":"Dejerine J","year":"1895","unstructured":"Dejerine J, Dejerine-Klumpke A. Anatomie Des Centres Nerveux. Vol 1. Rueff Paris; 1895."},{"key":"b25","series-title":"Neuroimage","first-page":"258","article-title":"Functional neuroanatomical review of the ventral tegmental area","volume":"191","author":"Trutti AC","year":"2019","unstructured":"Trutti AC, Mulder MJ, Hommel B, Forstmann BU. Functional neuroanatomical review of the ventral tegmental area. Neuroimage. 2019;191:258\u2013268."},{"issue":"3","key":"b26","series-title":"J Comp Neurol","first-page":"490","article-title":"Course of motor and associative pallidothalamic projections in monkeys","volume":"429","author":"Baron MS","year":"2001","unstructured":"Baron MS, Sidib\u00e9 M, DeLong MR, Smith Y. Course of motor and associative pallidothalamic projections in monkeys. J Comp Neurol. 2001;429(3):490\u2013501."},{"issue":"1","key":"b27","series-title":"J Comp Neurol","first-page":"36","article-title":"Dopaminergic innervation of the basal ganglia in the squirrel monkey as revealed by tyrosine hydroxylase immunohistochemistry","volume":"289","author":"Lavoie B","year":"1989","unstructured":"Lavoie B, Smith Y, Parent A. Dopaminergic innervation of the basal ganglia in the squirrel monkey as revealed by tyrosine hydroxylase immunohistochemistry. J Comp Neurol. 1989;289(1):36\u201352."},{"issue":"1","key":"b28","series-title":"Neurosci Res","first-page":"51","article-title":"Extrastriatal dopaminergic innervation of human basal ganglia","volume":"34","author":"Cossette M","year":"1999","unstructured":"Cossette M, L\u00e9vesque M, Parent A. Extrastriatal dopaminergic innervation of human basal ganglia. Neurosci Res. 1999;34(1):51\u201354."},{"issue":"3-4","key":"b29","series-title":"J Chem Neuroanat","first-page":"207","article-title":"Dopaminergic innervation of human basal ganglia","volume":"20","author":"Prensa L","year":"2000","unstructured":"Prensa L, Cossette M, Parent A. Dopaminergic innervation of human basal ganglia. J Chem Neuroanat. 2000;20(3-4):207\u2013213."},{"issue":"4","key":"b30","series-title":"J Chem Neuroanat","first-page":"256","article-title":"Serotonin innervation of basal ganglia in monkeys and humans","volume":"41","author":"Parent M","year":"2011","unstructured":"Parent M, Wallman MJ, Gagnon D, Parent A. Serotonin innervation of basal ganglia in monkeys and humans. J Chem Neuroanat. 2011;41(4):256\u2013265."},{"issue":"1","key":"b31","series-title":"J Neural Eng","first-page":"011001","article-title":"Common misconceptions, hidden biases and modern challenges of dMRI tractography","volume":"17","author":"Rheault F","year":"2020","unstructured":"Rheault F, Poulin P, Valcourt Caron A, St-Onge E, Descoteaux M. Common misconceptions, hidden biases and modern challenges of dMRI tractography. J Neural Eng. 2020;17(1):011001."},{"issue":"3","key":"b32","series-title":"CNS Spectr","first-page":"282","article-title":"The medial forebrain bundle as a target for deep brain stimulation for obsessive-compulsive disorder","volume":"22","author":"Coenen VA","year":"2017","unstructured":"Coenen VA, Schlaepfer TE, Goll P,  The medial forebrain bundle as a target for deep brain stimulation for obsessive-compulsive disorder. CNS Spectr. 2017;22(3):282\u2013289."},{"issue":"12","key":"b33","series-title":"Biol Psychiatry","first-page":"1204","article-title":"Rapid effects of deep brain stimulation for treatment-resistant major depression","volume":"73","author":"Schlaepfer TE","year":"2013","unstructured":"Schlaepfer TE, Bewernick BH, Kayser S, M\u00e4dler B, Coenen VA. Rapid effects of deep brain stimulation for treatment-resistant major depression. Biol Psychiatry. 2013;73(12):1204\u20131212."},{"issue":"5","key":"b34","series-title":"eNeuro","first-page":"ENEURO.0116","article-title":"Understanding the significance of the hypothalamic nature of the subthalamic nucleus","volume":"8","author":"Barbier M","year":"2021","unstructured":"Barbier M, Risold PY. Understanding the significance of the hypothalamic nature of the subthalamic nucleus. eNeuro. 2021;8(5):ENEURO.0116\u201321.2021."},{"key":"b35","series-title":"Front Neuroanat","first-page":"30","article-title":"Roles of multiple globus pallidus territories of monkeys and humans in motivation, cognition and action: an anatomical, physiological and pathophysiological review","volume":"11","author":"Saga Y","year":"2017","unstructured":"Saga Y, Hoshi E, Tremblay L. Roles of multiple globus pallidus territories of monkeys and humans in motivation, cognition and action: an anatomical, physiological and pathophysiological review. Front Neuroanat. 2017;11:30."},{"issue":"12","key":"b36","series-title":"Cureus","first-page":"e11846","article-title":"The anterior globus pallidus externus of basal ganglia as primarily a limbic and associative territory","volume":"12","author":"Saad P","year":"2020","unstructured":"Saad P, Shendrik KS, Karroum PJ, Azizi H, Jolayemi A. The anterior globus pallidus externus of basal ganglia as primarily a limbic and associative territory. Cureus. 2020;12(12):e11846."},{"key":"b37","series-title":"The Basal Ganglia IX","first-page":"85","article-title":"High-frequency stimulation of the globus pallidus external segment biases behavior toward reward","author":"Adler A","year":"2009","unstructured":"Adler A, Joshua M, Finkes I, Bergman H. High-frequency stimulation of the globus pallidus external segment biases behavior toward reward. In: Groenewegen HJ, Voorn P, Berendse HW, Mulder AB, Cools AR, eds.The Basal Ganglia IX. Springer; 2009:85-96."},{"issue":"1","key":"b38","series-title":"J Neuropsychiatry Clin Neurosci","first-page":"71","article-title":"Reduced volume of limbic system-affiliated basal ganglia in mood disorders: preliminary data from a postmortem study","volume":"11","author":"Baumann B","year":"1999","unstructured":"Baumann B, Danos P, Krell D,  Reduced volume of limbic system-affiliated basal ganglia in mood disorders: preliminary data from a postmortem study. J Neuropsychiatry Clin Neurosci. 1999;11(1):71\u201378."},{"key":"b39","series-title":"Neuroimage","first-page":"106","article-title":"FIBRASCAN: a novel method for 3D white matter tract reconstruction in MR space from cadaveric dissection","volume":"103","author":"Zemmoura I","year":"2014","unstructured":"Zemmoura I, Serres B, Andersson F,  FIBRASCAN: a novel method for 3D white matter tract reconstruction in MR space from cadaveric dissection. 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