{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:34:43Z","timestamp":1793666083175,"version":"4.5.1"},"reference-count":61,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Chronic subdural hematoma (CSDH) is a prevalent neurosurgical condition, particularly among the elderly. Various treatment options exist, but recurrence rates remain high. This systematic review and meta-analysis aims to assess the efficacy and safety of tranexamic acid (TXA) in the management of CSDH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors conducted a comprehensive literature search adhering to the 2020 PRISMA guidelines, involving three primary databases (Scopus, PubMed, and Web of Science) that were searched for articles compiled from inception until October 20, 2023. The primary outcome was recurrence of CSDH, and secondary outcomes included complications and SDH volume following TXA treatment. The mean difference and odds ratios with 95% confidence intervals were calculated using the random-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 5 studies, involving 643 patients in the TXA group and 736 patients in the non-TXA group, met the inclusion criteria. The meta-analysis revealed that TXA use led to a significantly lower CSDH recurrence (OR 0.35, 95% CI 0.23\u20130.53; p &lt; 0.01) without increasing complications (OR 1.84, 95% CI 0.43\u20137.95; p = 0.42). Additionally, TXA users had a significantly lower CSDH volume compared to the non-TXA group at 3-month follow-up (mean difference \u22124.56, 95% CI \u22128.76 to \u22120.36; p = 0.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The findings suggest that TXA might be a promising agent for reducing the risk of CSDH recurrence without elevating the risk of complications. However, these results should be interpreted cautiously due to the limited number of studies included and the methodological heterogeneity. Further large-scale randomized controlled trials are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2024.1.jns232463","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T20:41:16Z","timestamp":1712349676000},"page":"945-954","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy and safety of tranexamic acid in the management of chronic subdural hematoma: a systematic review and meta-analysis"],"prefix":"10.3171","volume":"141","author":[{"given":"Basel","family":"Musmar","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Neurointerventional Radiology, Louisiana State University, Shreveport, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atakan","family":"Orscelik","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Division of Neuroendovascular Surgery, Medical University of South Carolina, Charleston, South Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Salim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Neurointerventional Radiology, Louisiana State University, Shreveport, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimer","family":"Adeeb","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Neurointerventional Radiology, Louisiana State University, Shreveport, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Spellicy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Duke University Hospital, Durham, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihad","family":"Abdelgadir","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Duke University Hospital, Durham, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehad","family":"Azar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Mayo Clinic, Rochester, Minnesota; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo H.","family":"Cuellar-Saenz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Neurointerventional Radiology, Louisiana State University, Shreveport, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Guthikonda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Neurointerventional Radiology, Louisiana State University, Shreveport, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Duke University Hospital, Durham, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"J Neurosurg","first-page":"222","article-title":"Present epidemiology of chronic subdural hematoma in Japan: analysis of 63,358 cases recorded in a national administrative database","volume":"128","author":"Toi H","year":"2018","unstructured":"Toi H, Kinoshita K, Hirai S,  Present epidemiology of chronic subdural hematoma in Japan: analysis of 63,358 cases recorded in a national administrative database. 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