{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:38:32Z","timestamp":1792791512448,"version":"4.5.0"},"reference-count":148,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:p>Idiopathic normal pressure hydrocephalus (iNPH) is characterized by the clinical triad of cognitive impairment, gait disturbances, and urinary incontinence, coupled with ventricular enlargement on brain imaging. The pathophysiology of iNPH remains complex, with varied patient responses to CSF diversion and a generally progressive nature of the disease. This scoping review aimed to provide an overview of the glymphatic system (GS) and its role in the development of iNPH. The review highlights the crucial function of the GS in maintaining brain homeostasis by clearing waste products from the interstitial space. Dysfunction in this system leads to impaired CSF clearance, resulting in the accumulation of neurotoxic substances that contribute to the symptoms of iNPH. Additionally, potential shared pathophysiological pathways between iNPH and other conditions affecting the GS such as aging, diabetes mellitus, hypertension, and sleep disorders are discussed. The findings suggest that GS dysfunction is a key factor in iNPH pathogenesis and may also be linked to the disease\u2019s poor responsiveness to shunt treatment. By enhancing understanding of these mechanisms, there is potential to develop targeted therapies aimed at restoring glymphatic function, thereby improving outcomes for patients with iNPH.<\/jats:p>","DOI":"10.3171\/2024.12.jns2420","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T06:15:49Z","timestamp":1743228949000},"page":"135-145","source":"Crossref","is-referenced-by-count":8,"title":["Implications of the glymphatic system in the pathogenesis of normal pressure hydrocephalus: an illustrated scoping review"],"prefix":"10.3171","volume":"143","author":[{"given":"Matias L.","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Texas Medical Branch, Galveston, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Casanova-Martinez","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Universidad de Valparaiso School of Medicine, San Felipe, Chile;"},{"name":"7 Laboratorio de Neuroanatom\u00eda Microquir\u00fargica (LaNeMic), Facultad de Medicina, Universidad de Buenos Aires, Argentina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanwen","family":"Chen","sequence":"additional","affiliation":[{"name":"National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland;"},{"name":"Department of Neurology, MedStar Georgetown University Hospital, Washington, DC; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Colasurdo","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Oregon Health & Science University, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Texas Medical Branch, Galveston, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"N Engl J Med","first-page":"117","article-title":"Symptomatic occult hydrocephalus with \"normal\" cerebrospinal-fluid pressure. A treatable syndrome","volume":"273","author":"Adams RD","year":"1965","unstructured":"Adams RD, Fisher CM, Hakim S, Ojemann RG, Sweet WH. Symptomatic occult hydrocephalus with \"normal\" cerebrospinal-fluid pressure. A treatable syndrome. N Engl J Med. 1965;273:117\u2013126."},{"issue":"6","key":"b2","series-title":"World Neurosurg","first-page":"2002","article-title":"Epidemiology of idiopathic normal pressure hydrocephalus: a systematic review of the literature","volume":"84","author":"Mart\u00edn-L\u00e1ez R","year":"2015","unstructured":"Mart\u00edn-L\u00e1ez R, Caballero-Arzapalo H, L\u00f3pez-Men\u00e9ndez LA, Arango-Lasprilla JC, V\u00e1zquez-Barquero A. Epidemiology of idiopathic normal pressure hydrocephalus: a systematic review of the literature. World Neurosurg. 2015;84(6):2002\u20132009."},{"issue":"2","key":"b3","series-title":"Acta Neurol Scand","first-page":"101","article-title":"A systematic review on the epidemiology of normal pressure hydrocephalus","volume":"141","author":"Zaccaria V","year":"2020","unstructured":"Zaccaria V, Bacigalupo I, Gervasi G,  A systematic review on the epidemiology of normal pressure hydrocephalus. Acta Neurol Scand. 2020;141(2):101\u2013114."},{"issue":"5","key":"b4","series-title":"Neurol Clin Pract","first-page":"375","article-title":"Diagnosis and management of idiopathic normal-pressure hydrocephalus","volume":"3","author":"Williams MA","year":"2013","unstructured":"Williams MA, Relkin NR. Diagnosis and management of idiopathic normal-pressure hydrocephalus. Neurol Clin Pract. 2013;3(5):375\u2013385."},{"issue":"7","key":"b5","series-title":"J Neurol Neurosurg Psychiatry","first-page":"806","article-title":"Natural course of idiopathic normal pressure hydrocephalus","volume":"85","author":"Andr\u00e9n K","year":"2014","unstructured":"Andr\u00e9n K, Wikkels\u00f8 C, Tisell M, Hellstr\u00f6m P. Natural course of idiopathic normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry. 2014;85(7):806\u2013810."},{"issue":"5","key":"b6","series-title":"J Anat","first-page":"702","article-title":"Lymphatic vessels of the dura mater: a new discovery?","volume":"227","author":"Bucchieri F","year":"2015","unstructured":"Bucchieri F, Farina F, Zummo G, Cappello F. Lymphatic vessels of the dura mater: a new discovery? J Anat. 2015;227(5):702\u2013703."},{"issue":"1","key":"b7","series-title":"J Med Res","first-page":"51","article-title":"Studies on cerebro-spinal fluid. No. III. The pathways of escape from the subarachnoid spaces with particular reference to the arachnoid villi","volume":"31","author":"Weed LH","year":"1914","unstructured":"Weed LH. Studies on cerebro-spinal fluid. No. III. The pathways of escape from the subarachnoid spaces with particular reference to the arachnoid villi. J Med Res. 1914;31(1):51\u201391."},{"issue":"147","key":"b8","series-title":"Sci Transl Med","first-page":"147ra111","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff JJ","year":"2012","unstructured":"Iliff JJ, Wang M, Liao Y,  A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2. Sci Transl Med. 2012;4(147):147ra111."},{"issue":"12","key":"b9","series-title":"Neurochem Res","first-page":"2583","article-title":"The glymphatic system: a beginner\u2019s guide","volume":"40","author":"Jessen NA","year":"2015","unstructured":"Jessen NA, Munk AS, Lundgaard I, Nedergaard M. The glymphatic system: a beginner\u2019s guide. Neurochem Res. 2015;40(12):2583\u20132599."},{"issue":"1","key":"b10","series-title":"Mol Ther","first-page":"69","article-title":"The \"perivascular pump\" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain","volume":"14","author":"Hadaczek P","year":"2006","unstructured":"Hadaczek P, Yamashita Y, Mirek H,  The \"perivascular pump\" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain. Mol Ther. 2006;14(1):69\u201378."},{"issue":"5","key":"b11","series-title":"AJNR Am J Neuroradiol","first-page":"831","article-title":"CSF flow in the brain in the context of normal pressure hydrocephalus","volume":"36","author":"Bradley WG Jr","year":"2015","unstructured":"Bradley WG Jr. CSF flow in the brain in the context of normal pressure hydrocephalus. AJNR Am J Neuroradiol. 2015;36(5):831\u2013838."},{"issue":"1","key":"b12","series-title":"Fluids Barriers CNS","first-page":"26","article-title":"Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited","volume":"19","author":"MacAulay N","year":"2022","unstructured":"MacAulay N, Keep RF, Zeuthen T. Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited. Fluids Barriers CNS. 2022;19(1):26."},{"issue":"3","key":"b13","series-title":"J Clin Invest","first-page":"1299","article-title":"Brain-wide pathway for waste clearance captured by contrast-enhanced MRI","volume":"123","author":"Iliff JJ","year":"2013","unstructured":"Iliff JJ, Lee H, Yu M,  Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest. 2013;123(3):1299\u20131309."},{"key":"b14","series-title":"Front Cell Neurosci","first-page":"981399","article-title":"Cellular changes at the glia-neuro-vascular interface in definite idiopathic normal pressure hydrocephalus","volume":"16","author":"Eide PK","year":"2022","unstructured":"Eide PK. Cellular changes at the glia-neuro-vascular interface in definite idiopathic normal pressure hydrocephalus. Front Cell Neurosci. 2022;16:981399."},{"issue":"5","key":"b15","series-title":"Neuropathol Appl Neurobiol","first-page":"474","article-title":"Astrogliosis and impaired aquaporin-4 and dystrophin systems in idiopathic normal pressure hydrocephalus","volume":"44","author":"Eide PK","year":"2018","unstructured":"Eide PK, Hansson HA. Astrogliosis and impaired aquaporin-4 and dystrophin systems in idiopathic normal pressure hydrocephalus. Neuropathol Appl Neurobiol. 2018;44(5):474\u2013490."},{"issue":"1","key":"b16","series-title":"Glia","first-page":"91","article-title":"Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus","volume":"67","author":"Hasan-Olive MM","year":"2019","unstructured":"Hasan-Olive MM, Enger R, Hansson HA, Nagelhus EA, Eide PK. Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus. 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J Alzheimers Dis. 2019;69(3):663\u2013669."},{"issue":"1","key":"b19","series-title":"JAMA Neurol","first-page":"91","article-title":"Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains","volume":"74","author":"Zeppenfeld DM","year":"2017","unstructured":"Zeppenfeld DM, Simon M, Haswell JD,  Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains. JAMA Neurol. 2017;74(1):91\u201399."},{"issue":"9","key":"b20","series-title":"Nat Rev Drug Discov","first-page":"698","article-title":"The amyloid cascade hypothesis for Alzheimer\u2019s disease: an appraisal for the development of therapeutics","volume":"10","author":"Karran E","year":"2011","unstructured":"Karran E, Mercken M, De Strooper B. The amyloid cascade hypothesis for Alzheimer\u2019s disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov. 2011;10(9):698\u2013712."},{"issue":"4","key":"b21","series-title":"J Alzheimers Dis","first-page":"975","article-title":"Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimer\u2019s disease neurons","volume":"57","author":"Rajmohan R","year":"2017","unstructured":"Rajmohan R, Reddy PH. Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimer\u2019s disease neurons. J Alzheimers Dis. 2017;57(4):975\u2013999."},{"issue":"8","key":"b22","series-title":"Nat Rev Neurol","first-page":"457","article-title":"Clearance systems in the brain-implications for Alzheimer disease","volume":"11","author":"Tarasoff-Conway JM","year":"2015","unstructured":"Tarasoff-Conway JM, Carare RO, Osorio RS,  Clearance systems in the brain-implications for Alzheimer disease. 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J Neurosurg. 2011;115(1):159\u2013164."},{"issue":"10","key":"b30","series-title":"Brain","first-page":"2691","article-title":"Glymphatic MRI in idiopathic normal pressure hydrocephalus","volume":"140","author":"Ringstad G","year":"2017","unstructured":"Ringstad G, Vatnehol SAS, Eide PK. Glymphatic MRI in idiopathic normal pressure hydrocephalus. Brain. 2017;140(10):2691\u20132705."},{"issue":"19","key":"b31","series-title":"Neurology","first-page":"1711","article-title":"Pulse wave velocity is associated with \u03b2-amyloid deposition in the brains of very elderly adults","volume":"81","author":"Hughes TM","year":"2013","unstructured":"Hughes TM, Kuller LH, Barinas-Mitchell EJ,  Pulse wave velocity is associated with \u03b2-amyloid deposition in the brains of very elderly adults. 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Jpn J Radiol. 2017;35(4):172\u2013178."},{"issue":"3","key":"b34","series-title":"J Neurosurg","first-page":"612","article-title":"Noninvasive assessment of glymphatic dysfunction in idiopathic normal pressure hydrocephalus with diffusion tensor imaging","volume":"140","author":"Georgiopoulos C","year":"2023","unstructured":"Georgiopoulos C, Tisell A, Holmgren RT,  Noninvasive assessment of glymphatic dysfunction in idiopathic normal pressure hydrocephalus with diffusion tensor imaging. J Neurosurg. 2023;140(3):612\u2013620."},{"issue":"7","key":"b35","series-title":"J Cereb Blood Flow Metab","first-page":"1355","article-title":"Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: a glymphatic magnetic resonance imaging study","volume":"39","author":"Eide PK","year":"2019","unstructured":"Eide PK, Ringstad G. 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JCI Insight. 2021;6(9):e147063."},{"issue":"13","key":"b37","series-title":"JCI Insight","first-page":"e121537","article-title":"Brain-wide glymphatic enhancement and clearance in humans assessed with MRI","volume":"3","author":"Ringstad G","year":"2018","unstructured":"Ringstad G, Valnes LM, Dale AM,  Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. JCI Insight. 2018;3(13):e121537."},{"issue":"2","key":"b38","series-title":"Cold Spring Harb Perspect Biol","first-page":"a021808","article-title":"Place cells, grid cells, and memory","volume":"7","author":"Moser MB","year":"2015","unstructured":"Moser MB, Rowland DC, Moser EI. Place cells, grid cells, and memory. 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