{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T09:05:54Z","timestamp":1780131954004,"version":"3.54.0"},"reference-count":114,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Chordoma is a primary bone tumor with limited literature on its management because of its rarity. Resection, while considered the first-line treatment, does not always provide adequate tumor control. In this systematic review, the authors aimed to provide comprehensive insights by managing these tumors with stereotactic radiosurgery (SRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A systematic review was conducted according to PRISMA guidelines using the PubMed, Scopus, Web of Science, Embase, and Cochrane Library databases. Search terms included chordoma and radiosurgery and their equivalent terms. Data on baseline characteristics, SRS details, and outcomes were extracted. The Joanna Briggs Institute checklist was used to assess risk of bias. A meta-analysis was performed on relevant variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A total of 33 eligible studies encompassing 714 patients with skull base chordomas were included. Most studies had a low risk of bias. Patients, predominantly male (57.37%) with a mean age of 46.54 years, exhibited a conventional chordoma subtype (74.77%) and primary lesions (77.91%), mainly in the clivus (98.04%). The mean lesion volume was 13.49 cm\n                      <jats:sup>3<\/jats:sup>\n                      , and 96.68% of patients had undergone prior surgical attempts. Gamma Knife radiosurgery (88.76%) was the predominant SRS method. Radiologically, 27.19% of patients experienced tumor regression, while 55.02% showed no signs of disease progression at the latest follow-up. Progression occurred after a mean of 48.02 months. Symptom improvement was noted in 27.98% of patients. Radiosurgery was associated with a relatively low overall adverse event rate (11.94%), mainly cranial nerve deficits (8.72%). Meta-regression revealed that age and primary lesion type influenced symptom improvement, while factors like extent of resection, radiotherapy, and SRS type affected adverse event rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This systematic review provides evidence on the safety and effectiveness of radiosurgery in the management of skull base chordomas. Local tumor control was achieved in the majority of patients treated with SRS. Various baseline characteristics and SRS features have been analyzed to identify modifying factors for each outcome to provide a framework for informed decision-making when managing these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2024.2.focus249","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T04:50:31Z","timestamp":1714798231000},"page":"E10","source":"Crossref","is-referenced-by-count":6,"title":["Stereotactic radiosurgery in the management of skull base chordomas: a comprehensive systematic review and meta-analysis"],"prefix":"10.3171","volume":"56","author":[{"given":"Seyed Farzad","family":"Maroufi","sequence":"first","affiliation":[{"name":"Neurosurgical Research Network (NRN), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran;"},{"name":"Department of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Sadegh","family":"Fallahi","sequence":"additional","affiliation":[{"name":"Neurosurgical Research Network (NRN), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran;"},{"name":"Department of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadmahdi","family":"Sabahi","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Pauline Braathen Neurological Centre, Cleveland Clinic Florida, Weston, Florida; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyede Parmis","family":"Maroufi","sequence":"additional","affiliation":[{"name":"Neurosurgical Research Network (NRN), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason P.","family":"Sheehan","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"4","key":"b1","series-title":"Acta Neurochir (Wien)","first-page":"1003","article-title":"Gamma Knife stereotactic radiosurgery for the treatment of chordomas and chondrosarcomas","volume":"163","author":"Cahill J","year":"2021","unstructured":"Cahill J, Ibrahim R, Mezey G,  Gamma Knife stereotactic radiosurgery for the treatment of chordomas and chondrosarcomas. Acta Neurochir (Wien). 2021;163(4):1003\u20131011."},{"issue":"6","key":"b2","series-title":"Cureus","first-page":"e8401","article-title":"Stereotactic radiosurgery and stereotactic radiotherapy for malignant skull base tumors","volume":"12","author":"Mori Y","year":"2020","unstructured":"Mori Y, Kida Y, Matsushita Y, Mizumatsu S, Hatano M. Stereotactic radiosurgery and stereotactic radiotherapy for malignant skull base tumors. Cureus. 2020;12(6):e8401."},{"issue":"4","key":"b3","series-title":"Curr Probl Cancer","first-page":"100771","article-title":"Chordoma: Current status, problems, and future directions","volume":"45","author":"Wedekind MF","year":"2021","unstructured":"Wedekind MF, Widemann BC, Cote G. Chordoma: Current status, problems, and future directions. Curr Probl Cancer. 2021;45(4):100771."},{"issue":"4","key":"b4","series-title":"J Craniovertebr Junction Spine","first-page":"336","article-title":"Primary extradural tumors of the spinal column: a comprehensive treatment guide for the spine surgeon based on the 5th Edition of the World Health Organization bone and soft-tissue tumor classification","volume":"12","author":"Arvind V","year":"2021","unstructured":"Arvind V, Nevzati E, Ghaly M,  Primary extradural tumors of the spinal column: a comprehensive treatment guide for the spine surgeon based on the 5th Edition of the World Health Organization bone and soft-tissue tumor classification. J Craniovertebr Junction Spine. 2021;12(4):336\u2013360."},{"issue":"1","key":"b5","series-title":"Acta Orthop Scand","first-page":"49","article-title":"A clinicopathologic and prognostic study of a Swedish national series","volume":"52","author":"Eriksson B","year":"1981","unstructured":"Eriksson B, Gunterberg B, Kindblom LG. Chordoma. A clinicopathologic and prognostic study of a Swedish national series. Acta Orthop Scand. 1981;52(1):49\u201358."},{"issue":"1","key":"b6","series-title":"Am J Clin Oncol","first-page":"18","article-title":"Linear accelerator radiosurgery for recurrent malignant tumors of the skull base","volume":"21","author":"Kocher M","year":"1998","unstructured":"Kocher M, Voges J, Staar S, Treuer H, Sturm V, Mueller RP. Linear accelerator radiosurgery for recurrent malignant tumors of the skull base. Am J Clin Oncol. 1998;21(1):18\u201322."},{"issue":"2","key":"b7","series-title":"Lancet Oncol","first-page":"e71","article-title":"Building a global consensus approach to chordoma: a position paper from the medical and patient community","volume":"16","author":"Stacchiotti S","year":"2015","unstructured":"Stacchiotti S, Sommer J. Building a global consensus approach to chordoma: a position paper from the medical and patient community. 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Curr Radiol Rep. 2018;6(5):16."},{"issue":"5","key":"b55","series-title":"Rep Pract Oncol Radiother","first-page":"764","article-title":"Intracranial chordoma: radiosurgery, hypofractionated stereotactic radiotherapy and treatment outcomes","volume":"26","author":"Napieralska A","year":"2021","unstructured":"Napieralska A, Blamek S. Intracranial chordoma: radiosurgery, hypofractionated stereotactic radiotherapy and treatment outcomes. Rep Pract Oncol Radiother. 2021;26(5):764\u2013772."},{"issue":"1","key":"b56","series-title":"J Appl Clin Med Phys","first-page":"4095","article-title":"Comparing Gamma Knife and CyberKnife in patients with brain metastases","volume":"15","author":"Sio TT","year":"2014","unstructured":"Sio TT, Jang S, Lee SW, Curran B, Pyakuryal AP, Sternick ES. Comparing Gamma Knife and CyberKnife in patients with brain metastases. J Appl Clin Med Phys. 2014;15(1):4095."},{"issue":"10","key":"b57","series-title":"JBI Evid Synth","first-page":"2127","article-title":"Methodological quality of case series studies: an introduction to the JBI critical appraisal tool","volume":"18","author":"Munn Z","year":"2020","unstructured":"Munn Z, Barker TH, Moola S,  Methodological quality of case series studies: an introduction to the JBI critical appraisal tool. 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