{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:28:17Z","timestamp":1780072097124,"version":"3.54.0"},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Postoperative thrombotic complications represent a unique challenge in cranial neurosurgery as primary treatment involves therapeutic anticoagulation. The decision to initiate therapy and its timing is nuanced, as surgeons must balance the risk of catastrophic intracranial hemorrhage (ICH). With limited existing evidence to guide management, current practice patterns are subjective and inconsistent. The authors assessed their experience with early therapeutic anticoagulation (\u2264 7 days postoperatively) initiation for thrombotic complications in neurosurgical patients undergoing cranial surgery to better understand the risks of catastrophic ICH.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Adult patients treated with early therapeutic anticoagulation following cranial surgery were considered. Anticoagulation indications were restricted to thrombotic or thromboembolic complications. Records were retrospectively reviewed for demographics, surgical details, and anticoagulation therapy start. The primary outcome was the incidence of catastrophic ICH, defined as ICH resulting in reoperation or death within 30 days of anticoagulation initiation. As a secondary outcome, post-anticoagulation cranial imaging was reviewed for new or worsening acute blood products. Fisher\u2019s exact and Wilcoxon rank-sum tests were used to compare cohorts. Cumulative outcome analyses were performed for primary and secondary outcomes according to anticoagulation start time.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Seventy-one patients satisfied the inclusion criteria. Anticoagulation commenced on mean postoperative day (POD) 4.3 (SD 2.2). Catastrophic ICH was observed in 7 patients (9.9%) and was associated with earlier anticoagulation initiation (p = 0.02). Of patients with catastrophic ICH, 6 (85.7%) had intra-axial exploration during their index surgery. Patients with intra-axial exploration were more likely to experience a catastrophic ICH postoperatively compared to those with extra-axial exploration alone (OR 8.5, p = 0.04). Of the 58 patients with postoperative imaging, 15 (25.9%) experienced new or worsening blood products. Catastrophic ICH was 9 times more likely with anticoagulation initiation within 48 hours of surgery (OR 8.9, p = 0.01). The cumulative catastrophic ICH risk decreased with delay in initiation of anticoagulation, from 21.1% on POD 2 to 9.9% on POD 7. Concurrent antiplatelet medication was not associated with either outcome measure.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>The incidence of catastrophic ICH was significantly increased when anticoagulation was initiated within 48 hours of cranial surgery. Patients undergoing intra-axial exploration during their index surgery were at higher risk of a catastrophic ICH.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.2.jns24146","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T01:22:10Z","timestamp":1714785730000},"page":"1138-1146","source":"Crossref","is-referenced-by-count":4,"title":["Risk assessment of early therapeutic anticoagulation following cranial surgery: an institutional case series"],"prefix":"10.3171","volume":"141","author":[{"given":"Mark A.","family":"Davison","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpan A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Lilly","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Shost","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine, Cleveland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed I.","family":"Kashkoush","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit A.","family":"Krishnaney","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland;"},{"name":"Center for Spine Health, Neurological Institute, Cleveland Clinic, Cleveland;"},{"name":"Cerebrovascular Department, Neurological Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun R.","family":"Kshettry","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland;"},{"name":"Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland;"},{"name":"Cerebrovascular Department, Neurological Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina Z.","family":"Moore","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland;"},{"name":"Cerebrovascular Department, Neurological Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Cerebrovascular Department, Neurological Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Bain","sequence":"additional","affiliation":[{"name":"Cerebrovascular Department, Neurological Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"J Neurosurg","first-page":"40","article-title":"Venous thromboembolism: deep venous thrombosis and pulmonary embolism in a neurosurgical population","volume":"114","author":"Khaldi A","year":"2011","unstructured":"Khaldi A, Helo N, Schneck MJ, Origitano TC. 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