{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:48:37Z","timestamp":1765889317094,"version":"3.28.2"},"reference-count":18,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Diabetes is often linked to poorer outcomes in patients with moyamoya disease (MMD). However, experience has shown that certain individuals with diabetes have favorable outcomes after encephaloduroarteriosynangiosis (EDAS). The authors aimed to develop a nomogram to predict good neoangiogenesis in patients with MMD and type 2 diabetes mellitus (T2DM) to aid neurosurgeons in the identification of suitable candidates for EDAS.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Adults with MMD and T2DM who underwent EDAS between June 2004 and December 2018 were included in the analysis. In total, 126 patients (213 hemispheres) with MMD and T2DM from the Fifth Medical Centre of the Chinese PLA General Hospital were included and randomly divided into training (152 hemispheres) and internal validation (61 hemispheres) cohorts at a ratio of 7:3. Univariate logistic and least absolute shrinkage and selection operator regression analyses were used to identify the significant factors associated with good neoangiogenesis, which were used to develop a nomogram. The discrimination, calibration, and clinical utility were assessed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>A total of 213 hemispheres in 126 patients were reviewed, including 152 (71.36%) hemispheres with good postoperative collateral formation and 61 (28.64%) with poor postoperative collateral formation. The authors selected 4 predictors (FGD5 rs11128722, VEGFA rs9472135, Suzuki stage, and internal carotid artery [ICA] moyamoya vessels) for nomogram development. The C-indices of the nomogram in the training and internal validation cohorts were 0.873 and 0.841, respectively. The nomogram exhibited a sensitivity of 84.5% and specificity of 81.0%. The positive and negative predictive values were 92.1% and 66.7%, respectively. The calibration curves indicated high predictive accuracy, and receiver operating characteristic curve analysis showed the superiority of the nomogram. The decision-making analysis validated the fitness and clinical application value of this nomogram. Then a web-based calculator to facilitate clinical application was generated.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>The nomogram developed in this study accurately predicted neoangiogenesis in patients with MMD and T2DM after EDAS and may assist neurosurgeons in identifying suitable candidates for indirect revascularization surgery.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.2.jns24208","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T01:37:56Z","timestamp":1715996276000},"page":"1177-1186","source":"Crossref","is-referenced-by-count":4,"title":["Development and validation of a novel nomogram for predicting good neoangiogenesis after encephaloduroarteriosynangiosis in patients with moyamoya disease and type 2 diabetes mellitus: a case-control study"],"prefix":"10.3171","volume":"141","author":[{"given":"Jing-Jie","family":"Li","sequence":"first","affiliation":[{"name":"Medical School of Chinese PLA, Beijing;"},{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Ren","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA, Beijing;"},{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian-Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Eighth Medical Centre, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Yang","family":"Bao","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA, Beijing;"},{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Bao","family":"Guo","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA, Beijing;"},{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Qing","family":"Kong","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA, Beijing;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA, Beijing;"},{"name":"Neurology, First Medical Centre, Chinese PLA General Hospital, Beijing; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gan","family":"Gao","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA, Beijing;"},{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA, Beijing;"},{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Meng","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA, Beijing;"},{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He-Guan","family":"Fu","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huai-Yu","family":"Tong","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Duan","sequence":"additional","affiliation":[{"name":"Medical School of Chinese PLA, Beijing;"},{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"3","key":"b1","series-title":"Arch Neurol","first-page":"288","article-title":"Cerebrovascular \"moyamoya\" disease. Disease showing abnormal net-like vessels in base of brain","volume":"20","author":"Suzuki J","year":"1969","unstructured":"Suzuki J, Takaku A. Cerebrovascular \"moyamoya\" disease. Disease showing abnormal net-like vessels in base of brain. Arch Neurol. 1969;20(3):288\u2013299."},{"issue":"8","key":"b2","series-title":"Lancet Neurol","first-page":"747","article-title":"Moyamoya disease: diagnosis and interventions","volume":"21","author":"Ihara M","year":"2022","unstructured":"Ihara M, Yamamoto Y, Hattori Y,  Moyamoya disease: diagnosis and interventions. Lancet Neurol. 2022;21(8):747\u2013758."},{"issue":"5","key":"b3","series-title":"Neurol Med Chir (Tokyo)","first-page":"245","article-title":"Guidelines for diagnosis and treatment of moyamoya disease (spontaneous occlusion of the circle of Willis)","volume":"52","year":"2012","unstructured":"Research Committee on the Pathology and Treatment of Spontaneous Occlusion of the Circle of Willis. Guidelines for diagnosis and treatment of moyamoya disease (spontaneous occlusion of the circle of Willis). Neurol Med Chir (Tokyo). 2012;52(5):245\u2013266."},{"issue":"7","key":"b4","series-title":"Stroke","first-page":"1997","article-title":"Moyamoya disease in a primarily white, midwestern US population: increased prevalence of autoimmune disease","volume":"44","author":"Bower RS","year":"2013","unstructured":"Bower RS, Mallory GW, Nwojo M, Kudva YC, Flemming KD, Meyer FB. Moyamoya disease in a primarily white, midwestern US population: increased prevalence of autoimmune disease. Stroke. 2013;44(7):1997\u20131999."},{"issue":"2","key":"b5","series-title":"J Neurosurg","first-page":"308","article-title":"Surgical outcomes following encephaloduroarteriosynangiosis in adult moyamoya disease associated with Type 2 diabetes","volume":"125","author":"Ren B","year":"2016","unstructured":"Ren B, Zhang ZS, Liu WW,  Surgical outcomes following encephaloduroarteriosynangiosis in adult moyamoya disease associated with Type 2 diabetes. J Neurosurg. 2016;125(2):308\u2013314."},{"issue":"7","key":"b6","series-title":"Diabet Med","first-page":"539","article-title":"Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation","volume":"15","author":"Alberti KG","year":"1998","unstructured":"Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539\u2013553."},{"issue":"7","key":"b7","series-title":"Lancet Neurol","first-page":"603","article-title":"Clinical interpretation and use of stroke scales","volume":"5","author":"Kasner SE","year":"2006","unstructured":"Kasner SE. Clinical interpretation and use of stroke scales. Lancet Neurol. 2006;5(7):603\u2013612."},{"issue":"1","key":"b8","series-title":"Chin Neurosurg J","first-page":"5","article-title":"Chinese expert consensus on the treatment of MMD","volume":"9","author":"Bao XY","year":"2023","unstructured":"Bao XY, Duan L. Chinese expert consensus on the treatment of MMD. Chin Neurosurg J. 2023;9(1):5."},{"issue":"Suppl 2","key":"b9","series-title":"Clin Neurol Neurosurg","first-page":"S168","article-title":"\u2018Angiographic moyamoya\u2019 its definition, classification, and therapy","volume":"99","author":"Natori Y","year":"1997","unstructured":"Natori Y, Ikezaki K, Matsushima T, Fukui M. \u2018Angiographic moyamoya\u2019 its definition, classification, and therapy. Clin Neurol Neurosurg. 1997;99(Suppl 2):S168\u2013S172."},{"issue":"7","key":"b10","series-title":"Neurology","first-page":"e678","article-title":"Predictive role of heterozygous p.R4810K of RNF213 in the phenotype of Chinese moyamoya disease","volume":"94","author":"Wang Y","year":"2020","unstructured":"Wang Y, Zhang Z, Wei L,  Predictive role of heterozygous p.R4810K of RNF213 in the phenotype of Chinese moyamoya disease. Neurology. 2020;94(7):e678\u2013e686."},{"key":"b11","series-title":"Front Neurol","first-page":"1053193","article-title":"Postoperative cerebral infarction after revascularization in patients with moyamoya disease: incidence and risk factors","volume":"13","author":"Wang J","year":"2022","unstructured":"Wang J, Jiang H, Tang J, Lin C, Ni W, Gu Y. Postoperative cerebral infarction after revascularization in patients with moyamoya disease: incidence and risk factors. Front Neurol. 2022;13:1053193."},{"issue":"10","key":"b12","series-title":"Brain Sci","first-page":"1285","article-title":"Risk factors of transient neurological deficits and perioperative stroke after revascularization in patients with moyamoya disease","volume":"12","author":"Zhang X","year":"2022","unstructured":"Zhang X, Yang Y, Gan C,  Risk factors of transient neurological deficits and perioperative stroke after revascularization in patients with moyamoya disease. Brain Sci. 2022;12(10):1285."},{"key":"b13","series-title":"World Neurosurg","first-page":"161","article-title":"Ischemic stroke in young adults with moyamoya disease: prognostic factors for stroke recurrence and functional outcome after revascularization","volume":"103","author":"Zhao M","year":"2017","unstructured":"Zhao M, Deng X, Gao F,  Ischemic stroke in young adults with moyamoya disease: prognostic factors for stroke recurrence and functional outcome after revascularization. World Neurosurg. 2017;103:161\u2013167."},{"issue":"11","key":"b14","series-title":"Arterioscler Thromb Vasc Biol","first-page":"2694","article-title":"Facio-genital dysplasia-5 regulates matrix adhesion and survival of human endothelial cells","volume":"32","author":"Nakhaei-Nejad M","year":"2012","unstructured":"Nakhaei-Nejad M, Haddad G, Zhang QX, Murray AG. Facio-genital dysplasia-5 regulates matrix adhesion and survival of human endothelial cells. Arterioscler Thromb Vasc Biol. 2012;32(11):2694\u20132701."},{"issue":"4","key":"b15","series-title":"Arterioscler Thromb Vasc Biol","first-page":"988","article-title":"FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells","volume":"32","author":"Kurogane Y","year":"2012","unstructured":"Kurogane Y, Miyata M, Kubo Y,  FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2012;32(4):988\u2013996."},{"key":"b16","series-title":"Cell Signal","first-page":"125","article-title":"FGD5 sustains vascular endothelial growth factor A (VEGFA) signaling through inhibition of proteasome-mediated VEGF receptor 2 degradation","volume":"40","author":"Heldin J","year":"2017","unstructured":"Heldin J, O\u2019Callaghan P, Hern\u00e1ndez Vera R, Fuchs PF, Gerwins P, Kreuger J. FGD5 sustains vascular endothelial growth factor A (VEGFA) signaling through inhibition of proteasome-mediated VEGF receptor 2 degradation. Cell Signal. 2017;40:125\u2013132."},{"issue":"1","key":"b17","series-title":"FASEB J","first-page":"e22080","article-title":"FGD5 regulates endothelial cell PI3 kinase-\u03b2 to promote neo-angiogenesis","volume":"36","author":"Azad AK","year":"2022","unstructured":"Azad AK, Farhan MA, Murray CR,  FGD5 regulates endothelial cell PI3 kinase-\u03b2 to promote neo-angiogenesis. FASEB J. 2022;36(1):e22080."},{"issue":"1","key":"b18","series-title":"Diabetol Metab Syndr","first-page":"20","article-title":"Diagnostic significance of serum FGD5-AS1 and its predictive value for the development of cardiovascular diseases in patients with type 2 diabetes","volume":"14","author":"Wang Y","year":"2022","unstructured":"Wang Y, Wang J. 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