{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T13:40:08Z","timestamp":1733492408815,"version":"3.30.1"},"reference-count":43,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Posttraumatic headache (PTH) represents the most common acute and persistent symptom in children after concussion, yet there is no blood protein signature to stratify the risk of PTH after concussion to facilitate early intervention. This discovery study aimed to identify capillary blood protein markers, at emergency department (ED) presentation within 48 hours of concussion, to predict children at risk of persisting PTH at 2 weeks postinjury.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Capillary blood was collected using the Mitra Clamshell device from children aged 8\u201317 years who presented to the ED of the Royal Children\u2019s Hospital, Melbourne, Australia, within 48 hours of sustaining a concussion. Participants were followed up at 2 weeks postinjury to determine PTH status. PTH was defined per clinical guidelines as a new or worsened headache compared with preinjury. An untargeted proteomics analysis using data-independent acquisition (DIA) was performed. Principal component analysis and hierarchical clustering were used to reduce the dimensionality of the protein dataset.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>A total of 907 proteins were reproducibly identified from 82 children within 48 hours of concussion. The mean participant age was 12.78 years (SD 2.54 years, range 8\u201317 years); 70% of patients were male. Eighty percent met criteria for acute PTH in the ED, while one-third of participants with follow-up experienced PTH at 2 weeks postinjury (range 8\u201316 days). Hemoglobin subunit zeta (HBZ), cystatin B (CSTB), beta-ala-his dipeptidase (CNDP1), hemoglobin subunit gamma-1 (HBG1), and zyxin (ZYX) were weakly associated with PTH at 2 weeks postinjury based on up to a 7% increase in the PTH group despite nonsignificant Benjamini-Hochberg adjusted p values.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>This discovery study determined that no capillary blood protein markers, measured at ED presentation within 48 hours of concussion, can predict children at risk of persisting PTH at 2 weeks postinjury. While HBZ, CSTB, CNDP1, HBG1, and ZYX were weakly associated with PTH at 2 weeks postinjury, there was no specific blood protein signature predictor of PTH in children after concussion. There is an urgent need to discover new blood biomarkers associated with PTH to facilitate risk stratification and improve clinical management of pediatric concussion.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.2.peds23551","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T02:18:19Z","timestamp":1709950699000},"page":"610-618","source":"Crossref","is-referenced-by-count":0,"title":["Capillary blood protein markers of posttraumatic headache in children after concussion"],"prefix":"10.3171","volume":"33","author":[{"given":"Feiven","family":"Fan","sequence":"first","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"},{"name":"Melbourne School of Psychological Sciences, University of Melbourne, Victoria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz E.","family":"Babl","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"},{"name":"Departments of Pediatrics,"},{"name":"Critical Care, and"},{"name":"Emergency Department, Royal Children\u2019s Hospital, Melbourne, Victoria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella E. K.","family":"Swaney","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"},{"name":"Departments of Pediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J. C.","family":"Hearps","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"},{"name":"Critical Care, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Takagi","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"},{"name":"Melbourne School of Psychological Sciences, University of Melbourne, Victoria;"},{"name":"Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Victoria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha J.","family":"Emery-Corbin","sequence":"additional","affiliation":[{"name":"Advanced Technology and Biology Division, Walter and Eliza Hall Institute, Melbourne, Victoria;"},{"name":"Medical Biology, University of Melbourne, Victoria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura F.","family":"Dagley","sequence":"additional","affiliation":[{"name":"Advanced Technology and Biology Division, Walter and Eliza Hall Institute, Melbourne, Victoria;"},{"name":"Medical Biology, University of Melbourne, Victoria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jumana","family":"Yousef","sequence":"additional","affiliation":[{"name":"Advanced Technology and Biology Division, Walter and Eliza Hall Institute, Melbourne, Victoria;"},{"name":"Medical Biology, University of Melbourne, Victoria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia M.","family":"Parkin","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa C.","family":"Rausa","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"},{"name":"Departments of Pediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Anderson","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Fabiano","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"},{"name":"Melbourne School of Psychological Sciences, University of Melbourne, Victoria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Dunne","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"},{"name":"Departments of Pediatrics,"},{"name":"Department of Rehabilitation Medicine, Royal Children\u2019s Hospital, Melbourne, Victoria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Seal","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"},{"name":"Departments of Pediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin A.","family":"Davis","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"},{"name":"Department of Neurosurgery, Austin and Cabrini Hospitals, Melbourne, Victoria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"Attard","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"},{"name":"Departments of Pediatrics,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicki","family":"Anderson","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"},{"name":"Melbourne School of Psychological Sciences, University of Melbourne, Victoria;"},{"name":"Departments of Pediatrics,"},{"name":"Psychology Service, Royal Children\u2019s Hospital, Melbourne, Victoria, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Ignjatovic","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Melbourne, Victoria;"},{"name":"Departments of Pediatrics,"},{"name":"Johns Hopkins All Children\u2019s Institute for Clinical & Translational Research, St. Petersburg, Florida; and"},{"name":"Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"8","key":"b1","series-title":"Arch Phys Med Rehabil","first-page":"1343","article-title":"The American Congress of Rehabilitation Medicine diagnostic criteria for mild traumatic brain injury","volume":"104","author":"Silverberg ND","year":"2023","unstructured":"Silverberg ND, Iverson GL, Cogan A,  The American Congress of Rehabilitation Medicine diagnostic criteria for mild traumatic brain injury. Arch Phys Med Rehabil. 2023;104(8):1343\u20131355."},{"issue":"11","key":"b2","series-title":"Br J Sports Med","first-page":"838","article-title":"Consensus statement on concussion in sport\u2014the 5th international conference on concussion in sport held in Berlin, October 2016.","volume":"51","author":"McCrory P","year":"2017","unstructured":"McCrory P, Meeuwisse W, Dvo\u0159\u00e1k J,  Consensus statement on concussion in sport\u2014the 5th international conference on concussion in sport held in Berlin, October 2016.Br J Sports Med. 2017;51(11):838\u2013847."},{"issue":"10087","key":"b3","series-title":"Lancet","first-page":"2393","article-title":"Accuracy of PECARN, CATCH, and CHALICE head injury decision rules in children: a prospective cohort study","volume":"389","author":"Babl FE","year":"2017","unstructured":"Babl FE, Borland ML, Phillips N,  Accuracy of PECARN, CATCH, and CHALICE head injury decision rules in children: a prospective cohort study. Lancet. 2017;389(10087):2393\u20132402."},{"issue":"6","key":"b4","series-title":"J Neurosurg Pediatr","first-page":"647","article-title":"Characteristics of concussion based on patient age and sex: a multicenter prospective observational study","volume":"28","author":"Babl FE","year":"2021","unstructured":"Babl FE, Rausa VC, Borland ML,  Characteristics of concussion based on patient age and sex: a multicenter prospective observational study. J Neurosurg Pediatr. 2021;28(6):647\u2013656."},{"issue":"2","key":"b5","series-title":"Pediatrics","first-page":"e20162003","article-title":"Validation of a score to determine time to postconcussive recovery","volume":"139","author":"Hearps SJ","year":"2017","unstructured":"Hearps SJ, Takagi M, Babl FE,  Validation of a score to determine time to postconcussive recovery. Pediatrics. 2017;139(2):e20162003."},{"issue":"10","key":"b6","series-title":"JAMA","first-page":"1014","article-title":"Clinical risk score for persistent postconcussion symptoms among children with acute concussion in the ED","volume":"315","author":"Zemek R","year":"2016","unstructured":"Zemek R, Barrowman N, Freedman SB,  Clinical risk score for persistent postconcussion symptoms among children with acute concussion in the ED. JAMA. 2016;315(10):1014\u20131025."},{"issue":"12","key":"b7","series-title":"J Neurotrauma","first-page":"1392","article-title":"Trajectories and predictors of clinician-determined recovery after child concussion","volume":"37","author":"Anderson V","year":"2020","unstructured":"Anderson V, Davis GA, Takagi M,  Trajectories and predictors of clinician-determined recovery after child concussion. J Neurotrauma. 2020;37(12):1392\u20131400."},{"issue":"1","key":"b8","series-title":"Cephalalgia","first-page":"1","article-title":"Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders,","volume":"38","year":"2018","unstructured":"Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1\u2013211."},{"issue":"3","key":"b9","series-title":"JAMA Netw Open","first-page":"e211312","article-title":"Evaluation of posttraumatic headache phenotype and recovery time after youth concussion","volume":"4","author":"Kamins J","year":"2021","unstructured":"Kamins J, Richards R, Barney BJ,  Evaluation of posttraumatic headache phenotype and recovery time after youth concussion. JAMA Netw Open. 2021;4(3):e211312."},{"issue":"3","key":"b10","series-title":"JAMA Pediatr","first-page":"259","article-title":"Prognosticators of persistent symptoms following pediatric concussion: a systematic review","volume":"167","author":"Zemek RL","year":"2013","unstructured":"Zemek RL, Farion KJ, Sampson M, McGahern C. Prognosticators of persistent symptoms following pediatric concussion: a systematic review. JAMA Pediatr. 2013;167(3):259\u2013265."},{"issue":"12","key":"b11","series-title":"Br J Sports Med","first-page":"941","article-title":"Predictors of clinical recovery from concussion: a systematic review","volume":"51","author":"Iverson GL","year":"2017","unstructured":"Iverson GL, Gardner AJ, Terry DP,  Predictors of clinical recovery from concussion: a systematic review. Br J Sports Med. 2017;51(12):941\u2013948."},{"issue":"7","key":"b12","series-title":"Dev Med Child Neurol","first-page":"636","article-title":"Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort","volume":"55","author":"Kuczynski A","year":"2013","unstructured":"Kuczynski A, Crawford S, Bodell L, Dewey D, Barlow KM. Characteristics of post-traumatic headaches in children following mild traumatic brain injury and their response to treatment: a prospective cohort. Dev Med Child Neurol. 2013;55(7):636\u2013641."},{"issue":"3","key":"b13","series-title":"JAMA Netw Open","first-page":"e231993","article-title":"Association of posttraumatic headache with symptom burden after concussion in children","volume":"6","author":"van Ierssel JJ","year":"2023","unstructured":"van Ierssel JJ, Tang K, Beauchamp M,  Association of posttraumatic headache with symptom burden after concussion in children. JAMA Netw Open. 2023;6(3):e231993."},{"key":"b14","series-title":"Neurosci Biobehav Rev","first-page":"105498","article-title":"Post-traumatic headache pathophysiology in paediatric concussion: a systematic review","volume":"156","author":"Fan F","year":"2024","unstructured":"Fan F, Anderson V, Morawakage T,  Post-traumatic headache pathophysiology in paediatric concussion: a systematic review. Neurosci Biobehav Rev. 2024;156:105498."},{"key":"b15","series-title":"Front Neurol","article-title":"Putative Concussion Biomarkers Identified in Adolescent Male Athletes Using Targeted Plasma Proteomics","author":"Miller MR","unstructured":"Miller MR, Robinson M, Fischer L,  Putative Concussion Biomarkers Identified in Adolescent Male Athletes Using Targeted Plasma Proteomics. Front Neurol. Published online December 20, 2021. doi:10.3389\/fneur.2021.787480"},{"issue":"2","key":"b16","series-title":"Curr Neurol Neurosci Rep","first-page":"105","article-title":"Post-traumatic headache: pharmacologic management and targeting CGRP signaling","volume":"22","author":"Ashina H","year":"2022","unstructured":"Ashina H, Dodick DW. Post-traumatic headache: pharmacologic management and targeting CGRP signaling. Curr Neurol Neurosci Rep. 2022;22(2):105\u2013111."},{"issue":"2","key":"b17","series-title":"BMJ Open","first-page":"e041458","article-title":"Protocol for a randomised clinical trial of multimodal postconcussion symptom treatment and recovery: the Concussion Essentials study","volume":"11","author":"Anderson V","year":"2021","unstructured":"Anderson V, Rausa VC, Anderson N,  Protocol for a randomised clinical trial of multimodal postconcussion symptom treatment and recovery: the Concussion Essentials study. BMJ Open. 2021;11(2):e041458."},{"key":"b18","series-title":"Document GP42-A6","article-title":"Procedures and Devices for the Collection of Diagnostic Capillary Blood Specimens; Approved Standard","year":"2008","unstructured":"Procedures and Devices for the Collection of Diagnostic Capillary Blood Specimens; Approved Standard. 6th ed. Document GP42-A6. Clinical & Laboratory Standards Institute; 2008."},{"issue":"1","key":"b19","series-title":"Expert Rev Med Devices","first-page":"5","article-title":"Minimally invasive capillary blood sampling methods","volume":"20","author":"Hoffman MSF","year":"2023","unstructured":"Hoffman MSF, McKeage JW, Xu J, Ruddy BP, Nielsen PMF, Taberner AJ. Minimally invasive capillary blood sampling methods. Expert Rev Med Devices. 2023;20(1):5\u201316."},{"issue":"suppl 1","key":"b20","series-title":"Br J Sports Med","first-page":"i13","article-title":"Which symptom assessments and approaches are uniquely appropriate for paediatric concussion?","volume":"43","author":"Gioia GA","year":"2009","unstructured":"Gioia GA, Schneider JC, Vaughan CG, Isquith PK. Which symptom assessments and approaches are uniquely appropriate for paediatric concussion? Br J Sports Med. 2009;43(suppl 1):i13-i22."},{"issue":"4","key":"b21","series-title":"Arch Clin Neuropsychol","first-page":"348","article-title":"Psychometric characteristics of the postconcussion symptom inventory in children and adolescents","volume":"29","author":"Sady MD","year":"2014","unstructured":"Sady MD, Vaughan CG, Gioia GA. Psychometric characteristics of the postconcussion symptom inventory in children and adolescents. Arch Clin Neuropsychol. 2014;29(4):348\u2013363."},{"issue":"1","key":"b22","series-title":"J Neurosurg Pediatr","first-page":"1","article-title":"Cerebral blood flow in children with persisting postconcussive symptoms and posttraumatic headache at 2 weeks postconcussion","volume":"32","author":"Fan F","year":"2023","unstructured":"Fan F, Beare R, Takagi M,  Cerebral blood flow in children with persisting postconcussive symptoms and posttraumatic headache at 2 weeks postconcussion. J Neurosurg Pediatr. 2023;32(1):1\u20138."},{"issue":"7","key":"b23","series-title":"J Proteome Res","first-page":"2915","article-title":"Universal solid-phase protein preparation (USP3) for bottom-up and top-down proteomics","volume":"18","author":"Dagley LF","year":"2019","unstructured":"Dagley LF, Infusini G, Larsen RH, Sandow JJ, Webb AI. Universal solid-phase protein preparation (USP3) for bottom-up and top-down proteomics. J Proteome Res. 2019;18(7):2915\u20132924."},{"issue":"8","key":"b24","series-title":"Nat Protoc","first-page":"1896","article-title":"Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips","volume":"2","author":"Rappsilber J","year":"2007","unstructured":"Rappsilber J, Mann M, Ishihama Y. Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Nat Protoc. 2007;2(8):1896\u20131906."},{"issue":"1","key":"b25","series-title":"Nat Methods","first-page":"41","article-title":"DIA-NN: Neural networks and interference correction enable deep proteome coverage in high throughput","volume":"17","author":"Demichev V","year":"2020","unstructured":"Demichev V, Messner CB, Vernardis SI, Lilley KS, Ralser M. DIA-NN: Neural networks and interference correction enable deep proteome coverage in high throughput. Nat Methods. 2020;17(1):41\u201344."},{"issue":"1","key":"b26","series-title":"J R Stat Soc B","first-page":"289","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y","year":"1995","unstructured":"Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B. 1995;57(1):289\u2013300."},{"issue":"7","key":"b27","series-title":"Mol Cell Proteomics","first-page":"2501","article-title":"SWATH mass spectrometry performance using extended peptide MS\/MS assay libraries","volume":"15","author":"Wu JX","year":"2016","unstructured":"Wu JX, Song X, Pascovici D,  SWATH mass spectrometry performance using extended peptide MS\/MS assay libraries. Mol Cell Proteomics. 2016;15(7):2501\u20132514."},{"issue":"1","key":"b28","series-title":"Nat Commun","first-page":"2391","article-title":"Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C","volume":"13","author":"McCafferty C","year":"2022","unstructured":"McCafferty C, Cai T, Borgel D,  Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C. Nat Commun. 2022;13(1):2391."},{"key":"b29","series-title":"Free Radic Biol Med","first-page":"136","article-title":"Hemoglobin \u03b1 in the blood vessel wall","volume":"73","author":"Butcher JT","year":"2014","unstructured":"Butcher JT, Johnson T, Beers J, Columbus L, Isakson BE. Hemoglobin \u03b1 in the blood vessel wall. Free Radic Biol Med. 2014;73:136\u2013142."},{"key":"b30","series-title":"Front Biosci","first-page":"5406","article-title":"Cystatins: biochemical and structural properties, and medical relevance","volume":"13","author":"Turk V","year":"2008","unstructured":"Turk V, Stoka V, Turk D. Cystatins: biochemical and structural properties, and medical relevance. Front Biosci. 2008;13:5406\u20135420."},{"issue":"2","key":"b31","series-title":"In Vivo","first-page":"517","article-title":"Quantitative comparative proteomics reveals candidate biomarkers for the early prediction of gestational diabetes mellitus: a preliminary study","volume":"34","author":"Mavreli D","year":"2020","unstructured":"Mavreli D, Evangelinakis N, Papantoniou N, Kolialexi A. Quantitative comparative proteomics reveals candidate biomarkers for the early prediction of gestational diabetes mellitus: a preliminary study. In Vivo. 2020;34(2):517\u2013525."},{"issue":"2","key":"b32","series-title":"Molecules","first-page":"2299","article-title":"Carnosinases, their substrates and diseases","volume":"19","author":"Bellia F","year":"2014","unstructured":"Bellia F, Vecchio G, Rizzarelli E. Carnosinases, their substrates and diseases. Molecules. 2014;19(2):2299\u20132329."},{"issue":"11","key":"b33","series-title":"BioEssays","first-page":"949","article-title":"Zyxin: zinc fingers at sites of cell adhesion","volume":"19","author":"Beckerle MC","year":"1997","unstructured":"Beckerle MC. Zyxin: zinc fingers at sites of cell adhesion. BioEssays. 1997;19(11):949\u2013957."},{"issue":"11","key":"b34","series-title":"J Neurotrauma","first-page":"1768","article-title":"Plasma tumor necrosis factor alpha is a predictor of persisting symptoms post-concussion in children","volume":"36","author":"Parkin GM","year":"2019","unstructured":"Parkin GM, Clarke C, Takagi M,  Plasma tumor necrosis factor alpha is a predictor of persisting symptoms post-concussion in children. J Neurotrauma. 2019;36(11):1768\u20131775."},{"issue":"7","key":"b35","series-title":"Metabolomics","first-page":"100","article-title":"Quantitative metabolomics comparison of traditional blood draws and TAP capillary blood collection","volume":"14","author":"Catala A","year":"2018","unstructured":"Catala A, Culp-Hill R, Nemkov T, D\u2019Alessandro A. Quantitative metabolomics comparison of traditional blood draws and TAP capillary blood collection. Metabolomics. 2018;14(7):100."},{"issue":"5","key":"b36","series-title":"Crit Rev Clin Lab Sci","first-page":"294","article-title":"Capillary blood for point-of-care testing","volume":"54","author":"Tang R","year":"2017","unstructured":"Tang R, Yang H, Choi JR,  Capillary blood for point-of-care testing. Crit Rev Clin Lab Sci. 2017;54(5):294\u2013308."},{"issue":"4","key":"b37","series-title":"Int J Lab Hematol","first-page":"729","article-title":"Differences between capillary and venous blood counts in children\u2014a data mining approach","volume":"44","author":"Becker M","year":"2022","unstructured":"Becker M, Gscheidmeier T, Gro\u00df HJ,  Differences between capillary and venous blood counts in children\u2014a data mining approach. Int J Lab Hematol. 2022;44(4):729\u2013737."},{"issue":"9","key":"b38","series-title":"J Pain","first-page":"895","article-title":"Central sensitization: a generator of pain hypersensitivity by central neural plasticity","volume":"10","author":"Latremoliere A","year":"2009","unstructured":"Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain. 2009;10(9):895\u2013926."},{"issue":"1","key":"b39","series-title":"BMC Public Health","first-page":"249","article-title":"A systematic review of the effect of retention methods in population-based cohort studies","volume":"11","author":"Booker CL","year":"2011","unstructured":"Booker CL, Harding S, Benzeval M. A systematic review of the effect of retention methods in population-based cohort studies. BMC Public Health. 2011;11(1):249."},{"issue":"1-2","key":"b40","series-title":"Pain","first-page":"133","article-title":"Evidence for increased plasma levels of calcitonin gene-related peptide in migraine outside of attacks","volume":"86","author":"Ashina M","year":"2000","unstructured":"Ashina M, Bendtsen L, Jensen R, Schifter S, Olesen J. Evidence for increased plasma levels of calcitonin gene-related peptide in migraine outside of attacks. Pain. 2000;86(1-2):133\u2013138."},{"issue":"1","key":"b41","series-title":"J Headache Pain","first-page":"22","article-title":"The big CGRP flood\u2014sources, sinks and signalling sites in the trigeminovascular system","volume":"19","author":"Messlinger K","year":"2018","unstructured":"Messlinger K. The big CGRP flood\u2014sources, sinks and signalling sites in the trigeminovascular system. J Headache Pain. 2018;19(1):22."},{"key":"b42","series-title":"Front Physiol","first-page":"1249","article-title":"The role of calcitonin gene related peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects","volume":"9","author":"Kee Z","year":"2018","unstructured":"Kee Z, Kodji X, Brain SD. The role of calcitonin gene related peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects. Front Physiol. 2018;9:1249."},{"issue":"2","key":"b43","series-title":"Bioeng Transl Med","first-page":"e10476","article-title":"Microsampling tools for collecting, processing, and storing blood at the point-of-care","volume":"8","author":"Baillargeon KR","year":"2022","unstructured":"Baillargeon KR, Mace CR. Microsampling tools for collecting, processing, and storing blood at the point-of-care. Bioeng Transl Med. 2022;8(2):e10476."}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/33\/6\/article-p610.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/33\/6\/article-p610.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/33\/6\/article-p610.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T13:06:53Z","timestamp":1733490413000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/33\/6\/article-p610.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,1]]},"references-count":43,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/2024.2.peds23551","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"type":"print","value":"1933-0707"},{"type":"electronic","value":"1933-0715"}],"subject":[],"published":{"date-parts":[[2024,6,1]]}}}