{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:03:15Z","timestamp":1788904995975,"version":"build-2803163510"},"reference-count":40,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been demonstrated to achieve the highest rates of arthrodesis in multilevel lumbar fusion but is also associated with possible perioperative morbidity. A novel allograft (OSTEOAMP) is a differentiated allograft that retains growth factors supporting bone healing. The authors sought to compare the clinical and radiographic outcomes of rhBMP-2 and the novel allograft in lumbar interbody arthrodesis to determine if the latter may be a safer and equally effective alternative to rhBMP-2 for single- and multilevel posterior or transforaminal lumbar interbody fusion (PLIF or TLIF).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>Patients who underwent single- or multilevel TLIF or PLIF using either OSTEOAMP or rhBMP-2 at the authors\u2019 institution over a 2-year period were prospectively followed for 12 months. Healthcare utilization, safety measures, patient satisfaction, physical disability (measured on the Oswestry Disability Index [ODI]), back and leg pain (on the numeric rating scale [NRS]), quality of life (on the EQ-5D scale), and return to work (RTW) were prospectively recorded. For purposes of this study, this consecutive series was retrospectively analyzed and pseudarthrosis rates were assessed at 2 years of follow-up. All patients (100%) had both 12-month patient-reported outcome follow-up and 24-month clinical and radiographic follow-up.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>One thousand one hundred fifty-four patients (654 treated with OSTEOAMP, 500 with rhBMP-2) were prospectively enrolled in the institutional registry. After propensity score matching, there were no significant baseline differences between 330 novel allograft and 330 rhBMP-2 cases. Perioperative morbidity and 90-day hospital readmission (3.3% vs 2.4%, p = 0.485) did not significantly differ between the novel allograft and the rhBMP-2 cases. At the 2-year follow-up, symptomatic pseudarthrosis requiring revision surgery occurred in 8 patients (2.4%) with OSTEOAMP and 6 patients (1.8%) with rhBMP-2 (p = 0.589). The overall fusion rate at 2 years was similar between groups (p = 0.213). Both groups showed significant and equivalent improvement in patient-reported outcome measures (PROMs) from baseline to 12-month follow-up, with no significant difference in 1-year mean NRS leg pain score (2.5 vs 2.7), ODI (25 vs 26), quality-adjusted life years (0.73 vs 0.73), satisfaction (83% vs 80%), or RTW (6.6 vs 7 weeks).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>In the authors\u2019 institutional experience, OSTEOAMP is a clinically viable substitute for rhBMP-2 for single- and multilevel lumbar fusion. This novel allograft provides clinically effective arthrodesis and improvements in PROMs comparable to rhBMP-2 with a similar safety profile. Additional indications and outcome assessment in longitudinal studies are needed to further characterize this allogeneic graft.<\/jats:p>\n<\/jats:sec>","DOI":"10.3171\/2024.2.spine23569","type":"journal-article","created":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T02:03:14Z","timestamp":1715997794000},"page":"236-245","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of transforaminal and posterior lumbar interbody fusion outcomes in patients receiving a novel allograft versus rhBMP-2: a radiographic and patient-reported outcomes analysis"],"prefix":"10.3171","volume":"41","author":[{"given":"Ummey","family":"Hani","sequence":"first","affiliation":[{"name":"Carolina Neurosurgery & Spine Associates, Charlotte, North Carolina;"},{"name":"SpineFirst, Atrium Health, Charlotte, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Harrison","family":"Farber","sequence":"additional","affiliation":[{"name":"Barrow Neurological Institute, St. Joseph\u2019s Hospital and Medical Center, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Pfortmiller","sequence":"additional","affiliation":[{"name":"Carolina Neurosurgery & Spine Associates, Charlotte, North Carolina;"},{"name":"SpineFirst, Atrium Health, Charlotte, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Carolina Neurosurgery & Spine Associates, Charlotte, North Carolina;"},{"name":"SpineFirst, Atrium Health, Charlotte, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Bohl","sequence":"additional","affiliation":[{"name":"Carolina Neurosurgery & Spine Associates, Charlotte, North Carolina;"},{"name":"SpineFirst, Atrium Health, Charlotte, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Holland","sequence":"additional","affiliation":[{"name":"Carolina Neurosurgery & Spine Associates, Charlotte, North Carolina;"},{"name":"SpineFirst, Atrium Health, Charlotte, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"McGirt","sequence":"additional","affiliation":[{"name":"Carolina Neurosurgery & Spine Associates, Charlotte, North Carolina;"},{"name":"SpineFirst, Atrium Health, Charlotte, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"1","key":"b1","series-title":"J Orthop Surg Res","first-page":"93","article-title":"Radiographic and clinical outcomes following MIS-TLIF in patients with adult lumbar degenerative scoliosis","volume":"13","author":"Zhao Y","year":"2018","unstructured":"Zhao Y, Liang Y, Mao K. Radiographic and clinical outcomes following MIS-TLIF in patients with adult lumbar degenerative scoliosis. J Orthop Surg Res. 2018;13(1):93."},{"issue":"5","key":"b2","series-title":"J Spinal Disord Tech","first-page":"288","article-title":"Long-term durability of minimal invasive posterior transforaminal lumbar interbody fusion: a clinical and radiographic follow-up","volume":"24","author":"Rouben D","year":"2011","unstructured":"Rouben D, Casnellie M, Ferguson M. Long-term durability of minimal invasive posterior transforaminal lumbar interbody fusion: a clinical and radiographic follow-up. 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